Metformin Tablets
- Metformin Hydrochloride Extended Release Tablets
Therapeutic Class: Anti-Diabetics
Dosage Forms: Tablets
Brand Name: Metfinox-SR™
How it works?
Uses of Metformin Tablets
- Delay or reduce risk of type 2 diabetes
- For adult, overweight patients with Impaired Glucose Tolerance (IGT), Impaired Fasting Glucose (IFG), or increased HbA1C.
- Especially indicated in those at high risk of developing overt type 2 diabetes mellitus.
- Used when patients continue progressing towards diabetes despite 3–6 months of intensive lifestyle changes.
- Treatment of type 2 diabetes mellitus
- For adults, particularly overweight patients, when diet and exercise alone are insufficient to control blood sugar.
- Can be used as monotherapy, in combination with other oral antidiabetic agents, or with insulin.
Precautions of Metformin Tablets
- Lactic acidosis risk
- Rare but serious complication, often linked to acute worsening of renal function, cardiorespiratory illness, or sepsis.
- Metformin accumulation increases risk.
- Dehydration
- In cases of severe diarrhea, vomiting, fever, or reduced fluid intake, metformin should be temporarily discontinued.
- Contact a healthcare professional immediately.
- Renal function monitoring
- GFR must be assessed before starting therapy and regularly thereafter.
- Contraindicated if GFR < 30 ml/min.
- Temporarily discontinue if renal function is altered.
- Cardiac function
- Patients with heart failure are at higher risk of hypoxia and renal insufficiency.
- Safe in stable chronic heart failure with regular monitoring.
- Contraindicated in acute or unstable heart failure.
- Surgery
- Must be discontinued at the time of surgery under general, spinal, or epidural anesthesia.
- Restart no earlier than 48 hours post‑surgery, once oral nutrition resumes and renal function is stable.
Dosages administration of Metformin Tablets
Adults with normal renal function (GFR ≥ 90 mL/min)
Reduction in the risk or delay of the onset of type 2 diabetes:
- Metformin should only be considered where intensive lifestyle modifications for 3 to 6 months have not resulted in adequate glycaemic control.
- The therapy should be initiated with one tablet Metfinox-SR 500 mg once daily with the evening meal.
- After 10 to 15 days dose adjustment on the basis of blood glucose measurements is recommended (OGTT and/or FPG and/or HbA1C values to be within the normal range). A slow increase of dose may improve gastro-intestinal tolerability.
- The maximum recommended dose is 4 tablets (2000 mg) once daily with the evening meal.
- It is recommended to regularly monitor (every 3-6 months) the glycaemic status (OGTT and/or FPG and/or HbA1c value) as well as the risk factors to evaluate whether treatment needs to be continued, modified or discontinued.
- A decision to re-evaluate therapy is also required if the patient subsequently implements improvements to diet and/or exercise, or if changes to the medical
- condition will allow increased lifestyle interventions to be possible.
- Monotherapy in Type 2 diabetes mellitus and combination with other oral antidiabetic agents:
- The usual starting dose is one tablet of Metfinox-SR 500 mg once daily.
- After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. A slow increase of dose may improve gastro-intestinal tolerability. The maximum recommended dose is 4 tablets daily.
Combination with insulin:
- Metformin and insulin may be used in combination therapy to achieve better blood glucose control. The usual starting dose of Metfinox-SR is one 500 mg tablet once daily, while insulin dosage is adjusted on the basis of blood glucose measurements.
Elderly - Due to the potential for decreased renal function in elderly subjects, the metformin dosage should be adjusted based on renal function. Regular assessment of renal function is necessary.
- Benefit in the reduction of risk or delay of the onset of type 2 diabetes mellitus has not been established in patients 75 years and older and metformin initiation is therefore not recommended in these patients.
Side effects of Metformin Tablets
- Taste disturbance → Altered or metallic taste sensation.
- Gastrointestinal disorders → Nausea, vomiting, diarrhea, abdominal pain, and loss of appetite.
- These effects occur most frequently during initiation of therapy and usually resolve spontaneously in most cases.
Storage instruction of Metformin Tablets
Store below 30°C, preferably in a cool and dry place. Protect from light and moisture.
Keep the medicine out of reach of children.
Packing details of Metformin Tablets
10 x 10 Alu/PVC blister pack
Metfinox-SR is available in an Alu/PVC blister of 10 tablets. Such 10 blisters in a unit carton with package insert.
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GMP Certified Metformin Tablets Manufacturer
Conical Pharmaceuticals, headquartered in Ahmedabad, India, is a GMP‑certified manufacturer & exporter of Metformin Tablets company, delivering premium pharmaceutical and nutraceutical solutions worldwide. Metformin is a first‑line oral antidiabetic agent indicated for the reduction in risk or delay of type 2 diabetes in overweight adults with impaired glucose tolerance, impaired fasting glucose, or elevated HbA1C, especially those at high cardiovascular risk. It is also widely prescribed for the treatment of type 2 diabetes mellitus when diet and exercise alone do not achieve adequate glycemic control.
With exports planned into Central Africa, Central America, and the CIS Region, and expanding into Nigeria, Ghana, Zambia, Zimbabwe, Kenya, the Philippines, Singapore, and Afghanistan, Conical Pharmaceuticals ensures reliable supply and smooth market entry. Importers benefit from complete regulatory dossier support, including GMP Certification, COPP, COA, and Free Sale Certificates.
We also provide third‑party contract manufacturing, private labelling, and custom formulation options, empowering partners to launch their own brands with tailored solutions. With advanced R&D, flexible MOQ options, and consistent quality assurance, Conical Pharmaceuticals enables partners to expand their market presence while delivering effective, high‑quality antidiabetic therapies worldwide.
CUSTOM PACKAGING
Options available in size and style to meet your exact specifications and branding needs
SAMPLES AVAILABLE
Test before committing to bulk orders with complimentary samples for quality verification
LEAD TIME
45–60 days for timely delivery, ensuring reliable supply chain management
SHELF LIFE
Shelf Life: 24 months.
Frequently Asked Questions
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Conical Pharmaceuticals, headquartered in Ahmedabad, India, is a GMP‑certified manufacturer & exporter of Metformin Tablets.
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