Gastro-Resistant Aspirin tablet
- Gastro-Resistant Aspirin Tablets BP 75 mg
Therapeutic Class: Cardiovascular Agents
Dosage Forms: Tablets
Brand Name: Legosprin-75™
How it works?
Uses of Gastro-Resistant Aspirin tablet
Aspirin gastro-resistant tablets 75 mg are mainly used as a long-term blood thinner to help prevent blood clots, reducing the risk of heart attack, stroke, and angina. They are not painkillers but are prescribed to protect the heart and blood vessels.
Common uses of Gastro-Resistant Aspirin tablet include:
- Heart attack prevention: Low-dose aspirin helps stop clots from forming in arteries, lowering the chance of future heart attacks.
- Stroke prevention: It keeps blood flowing smoothly in the brain by preventing clumps of platelets.
- Angina management: It improves blood flow to the heart and reduces chest pain caused by blocked arteries.
- Post-surgery protection: Often prescribed after heart surgeries like bypass to prevent clots.
- General clot prevention: Used for patients at high risk of cardiovascular problems to avoid dangerous clots.
Precautions of Gastro-Resistant Aspirin tablet
Aspirin 75 mg tablets is not suitable for use as an anti-inflammatory/analgesic/antipyretic.
-Exercise caution in patients with allergic disease, impaired hepatic or renal function (avoid if severe), and dehydration, as the use of NSAIDs may worsen renal function. Perform liver function tests regularly in patients with slight or moderate hepatic insufficiency.
Aspirin may also precipitate bronchospasm or induce attacks of asthma in susceptible subjects or promote other hypersensitivity reactions.
Serious skin reactions, including Stevens-Johnson syndrome, rarely occur with the use of acetylsalicylic acid. Discontinue aspirin tablets at the first sign of a skin rash, mucosal lesions, or any other indication of hypersensitivity.
The elderly may be more susceptible to the toxic effects of salicylates. Avoid continuous prolonged use of aspirin in the elderly due to the risk of gastrointestinal bleeding and perforation, which can be fatal. When prolonged therapy is necessary, review patients regularly.
Take caution with patients who have glucose-6-phosphate dehydrogenase deficiency, as hemolytic anemia may occur.
Do not recommend aspirin 75 mg tablets during menorrhagia, as they may increase menstrual bleeding.
Aspirin prolongs bleeding time mainly by inhibiting platelet aggregation, so discontinue it several days before scheduled surgical procedures.
Exercise care when stopping antiplatelet therapy after stent insertion, whether after a fixed period or in preparation for a planned surgical procedure, as you must carefully assess the balance between stent thrombosis and excessive bleeding.
There is a possible association between aspirin and Reye’s Syndrome when given to children. Reye’s syndrome is a very rare disease, which affects the brain and liver, and can be fatal. For this reason, do not give aspirin to children under 16 years unless specifically indicated (e.g., for Kawasaki’s disease). Avoid aspirin in late pregnancy and generally during breastfeeding.
Avoid aspirin in late pregnancy and during breastfeeding.
Dosages administration of Gastro-Resistant Aspirin tablet
Dosage & Administration for Gastro-Resistant Aspirin tablet
- General Guidance Patients should seek medical advice before starting therapy for cardiovascular or cerebrovascular disease. Treatment should be reviewed at regular intervals.
- Adults (Long‑Term Use) The usual dose is 75–150 mg once daily. In certain cases, a doctor may recommend a higher dose for short‑term use, up to 300 mg daily.
- Antithrombotic Action At diagnosis: 150 mg (chewed for rapid absorption). Maintenance: 75 mg once daily thereafter.
- Elderly Patients Use with caution, as they are more prone to adverse events. The standard adult dose is appropriate unless severe renal or hepatic impairment is present.
- Children Not recommended for children under 16 years, except when specifically indicated (e.g., Kawasaki’s disease).
- Directions for Use For oral administration in adults only. Swallow the tablet whole with water; do not chew gastro‑resistant tablets.
Side effects of Gastro-Resistant Aspirin tablet
Side effects are grouped on the basis of System Organ Class. Within each system organ class, the frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000), and not known (cannot be estimated from the available data).
Blood and lymphatic system disorders
Common: Increased bleeding tendencies, Rare: Thrombocytopenia, granulocytosis, aplastic anaemia
Not Known: Cases of bleeding with prolonged bleeding time, such as epistaxis, haematuria, purpura, ecchymoses, haemoptysis, haematoma, cerebral haemorrhage and gingival bleeding,
Existing (hematemesis, melena) or occult gastrointestinal bleeding, which may lead to iron deficiency anemia (more common at higher doses). Haemolytic anaemia can occur in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Immune system disorders:
Rare: Hypersensitivity reactions, skin rashes, urticarial, asthma, bronchospasm, angiooedema,
allergic oedema, anaphylactic reactions including shock
Metabolism and digestive system disorders:
Not known: Hyperuricemia
Nervous system disorders
Rare: Intracranial haemorrhage, Not known: Headache, vertigo
Ear and labyrinth disorders
Not known: Reduced hearing ability; tinnitus
Vascular disorders
Rare: Hemorrhagic vasculitis
Respiratory, thoracic and mediastinal disorders
Uncommon: Rhinitis, dyspnoea, Rare: Bronchospasm, asthma attacks
Reproductive System and mammary disorders
Rare: Menorrhagia
Gastrointestinal disorders
Common: Dyspepsia, Rare: Severe gastrointestinal haemorrhage, nausea, vomiting, gastritis
Not known: Gastric or duodenal ulcers and perforation, diarrhoea.
Hepatobiliary disorders
Not known: Hepatic insufficiency
Skin and subcutaneous tissue disorders
Uncommon: Urticaria, Rare: Steven-Johnson syndrome, Lyell’s syndrome, purpura, erythema nodosum, and erythema multiforme.
Renal and urinary tract disorders
Not known: Impaired renal function, salt and water retention, urate kidney stones.
Storage instruction of Gastro-Resistant Aspirin tablet
Store below 30°C and protect from moisture.
Keep the medicine out of reach of children.
Packing details of Gastro-Resistant Aspirin tablet
10 x 10 Alu/Alu blister pack
Gastro-Resistant Aspirin tablet is available in an Alu/Alu blister of 10 tablets. Such 10 blisters in a unit carton with a package insert.
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CUSTOM PACKAGING
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SAMPLES AVAILABLE
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LEAD TIME
45–60 days for timely delivery, ensuring reliable supply chain management
SHELF LIFE
18 months when stored below 30°C, ensuring maximum stability and viability
Quality & Regulatory Certifications
WHO-GMP Certified Facility • FDA Approved (Jordan) • Full Regulatory Dossier Support • Certificate of Analysis • Free Sale Certificate • COPP Documentation
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