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Imipenem & Cilastatin Injection 1gm is a powerful antibiotic used to treat serious infections caused by a wide range of bacteria.
Key Actions:
Imipenem kills bacteria by stopping them from building their protective cell walls.
Cilastatin helps imipenem work better by stopping the kidneys from breaking it down too quickly.
Together, they fight both Gram-positive and Gram-negative bacteria, including tough ones like Pseudomonas aeruginosa.
Dosage Instructions for Adults while using Imipenem & Cilastatin Injection 1gm.
For Patients with Healthy Kidneys (Creatinine Clearance ≥ 90 mL/min)
| Dose | How to Give It |
|---|---|
| 500 mg | Infuse over 20 to 30 minutes |
| 1000 mg | Infuse over 40 to 60 minutes |
| Max per day | Do not exceed 4 grams per day |
Table 1: Dosage of Imipenem & Cilastatin Injection USP 1000 mg in Adult Patients with Creatinine Clearance Greater than or Equal to 90 mL/min
| Suspected or Proven Pathogen Susceptibility | Dosage of Imipenem & Cilastatin Injection USP 1000 mg |
| If the infection is suspected or proven to be due to a susceptible bacterial species | 500 mg every 6 hours OR 1000 mg every 8 hours |
| If the infection is suspected or proven to be due to bacterial species with intermediate susceptibility | 1000 mg every 6 hours |
Pediatric Dosage Guide
Not Recommended For:
General Guidelines:
The dose depends on the child’s age, weight, and type of infection.
Table 2: Recommended Imipenem & Cilastatin Injection USP 1000 mg Dosage in Pediatric Patients for Non-CNS Infections.
| Age | Dose (mg/kg) *,† | Frequency (hours) |
|
Greater than or equal to 3 Months of Age |
||
| 15-25 mg/kg | Every 6 hours | |
|
Less than or equal to 3 months of age (Greater than or equal to 1,500 g body weight) |
||
| 4 weeks to 3 months of age | 25 mg/kg | Every 6 hours |
| 1 to 4 weeks of age | 25 mg/kg | Every 8 hours |
| Less than 1 week of age | 25 mg/kg | Every 12 hours |
Doses less than or equal to 500 mg should be given by intravenous infusion over 20 to 30 minutes.
Doses greater than 500 mg should be given by intravenous infusion over 40 to 60 minutes.
Recommend that the maximum total daily dosage not exceed 4 g/day.
Dosage in Adult Patients with Renal Impairment
Patients with creatinine clearance less than 90 mL/min require dosage reduction of IMIPENEM & CILASTATIN INJECTION USP 1000 MG as indicated in the table below. The serum creatinine should represent a steady state of renal function. Use the Cockroft-Gault method described below to calculate the creatinine clearance:
Males =(weight in kg × (140 − age in years)) ÷ (72 × serum creatinine in mg/dL)
Females: (0.85) x (value calculated for males)
Table 3: Dosage of Imipenem & Cilastatin Injection USP 1000 mg for Adult Patients in Various Renal Function Groups Based on Estimated Creatinine Clearance (CLcr)
| Creatinine clearance (mL/min) | ||||
| Greater than or equal to 90 | Less than 90 to greater than or equal to 60 | Less than 60 to greater than or equal to 30 | Less than 30 to greater than or equal to 15 | |
| Dosage of IMIPENEM & CILASTATIN INJECTION USP 1000 MG*, | 500 mg
every 6 hours |
400 mg
every 6 hours |
300 mg
every 6 hours |
200 mg
every 6 hours |
| OR | ||||
| If the infection is suspected or proven to be due to a
susceptible bacterial species: |
1000 mg
every 8 hours |
500 mg
every 6 hours |
500 mg
every 8 hours |
500 mg
every 12 hours |
| Dosage of IMIPENEM & CILASTATIN INJECTION USP 1000 MG*,†
If the infection is suspected or proven to be due to bacterial species with intermediate susceptibility |
1000 mg every 6 hours | 750 mg every 8 hours | 500 mg every 6 hours | 500 mg every 12 hours |
How to Give This Imipenem & Cilastatin Injection 1gm?
Kidney Function and Safety
Dosing for Hemodialysis Patients
What This Medicine Does
Imipenem/Cilastatin is a powerful antibiotic used to treat serious infections caused by a wide range of bacteria.
Key Actions:
How It Works in the Body
Absorption & Distribution
Metabolism & Elimination
Special Considerations
Elderly Patients
Patients with Kidney Problems
Children
Serious Side Effects of Imipenem & Cilastatin Injection 1 gm
These are rare but can be dangerous:
Infections
Blood Problems
Immune Reactions
Nervous System
Ear Problems
Heart Issues
Breathing Problems
Stomach and Gut
People with low white blood cells may feel more sick to their stomach than others.
Liver Issues
Skin Reactions
Muscle and Joint
Kidney and Urine
Injection Site and General Symptoms
Important Safety Precautions while taking Imipenem & Cilastatin Injection 1gm.
When to Use
Allergic Reactions
Gut Health Warning
Use in Children
Brain and Nerve Effects
Muscle Weakness
Kidney Problems
Long-Term Use
Sodium Content
Store below 30°C temperature. Protect from light.
Keep the medicine out of reach of children.
10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal.
Imipenem & Cilastatin Injection in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections USP in a unit carton with a pack insert.
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Contract manufacturers already have the needed infrastructure and technical staff, so working with a CMO or CDMO can decrease the cost of manufacturing your pharmaceutical products.
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You can produce what you need when you need it without worrying about excess capacity. Additionally, CMOs understand the importance of quality and compliance, so you don't have to sacrifice safety for scalability.
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We have 7+ manufacturing sites with a minimum of WHO GMP certification and other country-specific approvals like NAFDAC approved, PPK Kenya Approved, TFDA Tanzania Approved, EU-GMP Approved.
We have below manufacturing capacity:
For Tablet, Capsule, and soft gel: up to 1 million units per shift
For Syrup: up to 0.05 Million per shift
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For Ointment and Cream: up to 0.1 million units per shift
For Suppository: 0.1 Million units per shift
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