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Hydrocortisone is indicated for a variety of conditions that require a rapid and intense corticosteroid effect. It is essential in managing endocrine disorders, including primary and secondary adrenocortical insufficiency, and is effective in treating collagen diseases such as systemic lupus erythematosus. This medication is also used for severe dermatological conditions like erythema multiforme (Stevens-Johnson syndrome) and for addressing allergic states, including bronchial asthma and anaphylactic reactions.
Additionally, hydrocortisone is valuable in treating gastrointestinal diseases such as ulcerative colitis and Crohn’s disease, as well as respiratory issues like aspiration of gastric contents. In medical emergencies, hydrocortisone plays a critical role in the treatment of shock secondary to adrenocortical insufficiency or when conventional therapy is ineffective, ensuring prompt and effective patient care.
Doctors may administer hydrocortisone for injection by intravenous injection, intravenous infusion, or intramuscular injection. Importantly, intravenous injection is the preferred method for initial emergency use. Furthermore, doctors should assess the patient’s condition to determine the most suitable route of administration for subsequent doses.
Additionally, this ensures that the treatment aligns with the patient’s needs. After the initial emergency period, doctors should then consider using a longer-acting injectable preparation or an oral preparation for ongoing treatment. Additionally, this allows for better management of the patient’s condition over time.
Dosage usually ranges from 100 mg to 500 mg, depending on the severity of the condition, and is administered by intravenous injection over a period of one to ten minutes. Moreover, doctors should closely monitor the patient during this time to assess the effectiveness of the treatment. Additionally, adjusting the dosage may be necessary based on the patient’s response.
Additionally, the healthcare provider may repeat this dose at intervals of 2, 4, or 6 hours based on the patient’s response and clinical condition. Furthermore, this approach allows for tailored treatment that effectively addresses the patient’s needs.
The incidence of predictable undesirable side effects associated with corticosteroid use, including hypothalamic-pituitary-adrenal suppression, correlates with several factors: specifically, the relative potency of the drug, the dosage, the timing of administration, and the duration of treatment. Moreover, such side effects include: Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1,000 to <1/100), Rare (≥1/10,000 to <1/1,000), Very rare (<1/10,000), Not known (cannot be estimated from the available data).
Frequency: Not Known
Patients may experience opportunistic infections and other infections.
Patients may develop leucocytosis.
Patients may have drug hypersensitivity, which can lead to an anaphylactic reaction or an anaphylactoid reaction.
Patients may present with Cushingoid facies, hypopituitarism, or steroid withdrawal syndrome.
Patients may experience metabolic acidosis, sodium retention, fluid retention, hypokalaemic alkalosis, and dyslipidaemia.
Patients may suffer from affective disorders, psychotic disorders, or mental disorders.
Patients may develop central serous chorioretinopathy, cataracts, glaucoma, exophthalmos, or blurred vision.
Patients may experience congestive heart failure.
Patients may develop pulmonary embolism or experience hiccups.
Patients may suffer from peptic ulcers, abdominal distension, oesophageal ulceration, or acute pancreatitis.
Patients may experience irregular menstruation or amenorrhoea.
1. Osteoporosis: Doctors should exercise caution when using corticosteroids in patients with osteoporosis, especially since long-term use and large doses of glucocorticoids generally associate with osteoporosis, putting post-menopausal females at particular risk.
2. Hypertension: This condition warrants caution when using corticosteroids.
3. Severe Affective Disorders: A history of severe affective disorders, especially previous steroid psychosis, necessitates careful consideration.
4. Diabetes: Corticosteroids, including hydrocortisone, can increase blood glucose levels, worsen pre-existing diabetes, and predispose those on long-term corticosteroid therapy to diabetes mellitus, particularly with a family history of diabetes.
5. Tuberculosis: A history of tuberculosis, whether existing or in the patient’s past, requires special care.
6. Glaucoma: Therefore, Doctors should closely monitor patients with glaucoma or a family history of glaucoma.
7. Corticosteroid-Induced Myopathy: Consequently, a previous history of this condition requires caution in corticosteroid use.
8. Liver Failure or Cirrhosis: Therefore, patients with these conditions need careful assessment.
9. Renal Insufficiency: Doctors should exercise caution when prescribing corticosteroids to these patients.
10. Epilepsy: Requires special attention when using corticosteroids.
11. Peptic Ulceration: Therefore, Doctors should consider this condition carefully.
12. Fresh Intestinal Anastomoses: As a result, Doctors should exercise caution with these patients.
13. Thrombophlebitis: Thus, a predisposition to this condition necessitates monitoring.
14. Pyogenic Infections: Consequently, patients with abscesses or other pyogenic infections require careful monitoring.
15. Ulcerative Colitis: For this reason, this condition needs special consideration.
16. Diverticulitis: Accordingly, close monitoring is necessary.
17. Myasthenia Gravis: Hence, Doctors should carefully assess patients with this condition.
18. Exanthematous Diseases: Doctors should exercise caution when considering corticosteroids for these patients.
Store below 30o C. Protected from light.
The reconstituted solution to be used immediately. If not used, can be stored for 24 hours at 2°C to 8°C at aseptic condition. If not used immediately, in-use storage times and conditions are the responsibility of the user.
Keep the medicine out of reach of children.
10 ml Clear-molded Glass Vial with grey bromobutyl rubber stopper, sealed with an orange flip-off aluminium seal. Hydrocortisone Sodium Succinate for Injection USP 500 mg powder for solution for injection is supplied in glass vial in unit carton with pack insert.
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