Following are the Uses of the Norethisterone Tablet 5mg
Low Dose (5–10 mg/day)
Used for non-cancerous gynecological conditions:
These effects are achieved by suppressing ovulation and reducing estrogen/progesterone levels, which helps stabilize the uterine lining.
High Dose
Used for disseminated breast carcinoma (advanced breast cancer):
Important precautions while taking Norethisterone Tablet 5mg
If menstrual bleeding should fail to follow a course of Norethisterone Tablet 5mg, the possibility of pregnancy must be excluded before a further course is given.
Therapy should be discontinued if the following occur:
– Jaundice or deterioration in liver function
– Significant increase in blood pressure
– New onset of migraine-type headache
Progestogens may cause fluid retention. Special care should be taken when prescribing norethisterone in patients with conditions that might be aggravated by this factor:
– Epilepsy
– Migraine
– Asthma
– Cardiac dysfunction
– Renal dysfunction
Risk of venous thromboembolism (VTE)
Long-term use of low-dose progestogens as part of combined oral contraception or combined hormone replacement therapy has been associated with an increased risk of venous thromboembolism, although the role of progestogens in this etiology is uncertain. A patient who develops symptoms suggestive of thromboembolic complications should have her status and need for treatment carefully assessed before continuing therapy.
Any patient who develops an acute impairment of vision, proptosis, diplopia, or migraine headache should be carefully evaluated ophthalmologically to exclude papilledema or retinal vascular lesions before continuing medication.
Generally recognized risk factors for VTE include a personal history or family history, severe obesity (BMI >30 kg/m2) and systemic lupus erythematosus (SLE). There is no consensus about the possible role of varicose veins in VTE.
Treatment with steroid hormones may add to these risk factors. Personal or strong family history of thromboembolism or recurrent spontaneous abortion should be investigated in order to exclude a thrombophilic predisposition. Until a thorough evaluation of thrombophilic factors has been made or anticoagulant treatment initiated, use of progestogens in these patients should be viewed as contraindicated. Where a patient is already taking anticoagulants, the risks and benefits of progestogen therapy should be carefully considered.
The risk of VTE may be temporarily increased with prolonged immobilization, major trauma, or major surgery. As in all postoperative patients, scrupulous attention should be given to prophylactic measures to prevent VTE. Where prolonged immobilization is likely to follow elective surgery, particularly abdominal or orthopedic surgery to the lower limbs, consideration should be given to stopping progestogen therapy 4-6 weeks preoperatively. Treatment should not be restarted until the patient is fully remobilized.
If VTE develops after initiating therapy, the drug should be withdrawn. Patients should be advised to contact their doctor immediately if they become aware of a potential thromboembolic symptom (e.g., painful swelling in the leg, sudden pain in the chest, dyspnoea).
Hepatic adenoma In very rare cases, hepatic adenomas may be associated with progesterone-only pill (POP) use. In some cases the hepatic adenoma may decrease in size or become undetectable after discontinuation of norethisterone. Rupture of hepatic adenomas may cause death through intra-abdominal hemorrhage. In extremely rare cases, hepatocellular carcinoma may be associated with combined oral contraceptive use.
Low-Dose Norethisterone Tablet 5mg:
1. Heavy or Irregular Periods (e.g., menorrhagia, dysmenorrhea):
2. Endometriosis:
3. To Delay Your Period:
4. Premenstrual Syndrome (PMS):
High-Dose Norethisterone Tablet 5mg Use:
For Breast Cancer (disseminated carcinoma):
How to Take Norethisterone Tablet 5mg?
Do NOT Take Norethisterone Tablet 5mg If You Have:
Possible Side Effects of Norethisterone Tablet 5 mg
Genitourinary (Reproductive Tract):
Breast & Reproductive System:
Nervous System & Mood:
Digestive System & Liver:
Hormonal & Metabolic Changes:
Heart & Blood Vessels:
Skin & Hair:
Allergic Reactions:
Other General Effects of Norethisterone Tablet 5mg:
Store in a dry place below 30°C and protect from light.
Keep out of reach of children.
3 x 10 Alu-PVC blister packs.
Norethisterone Tablets 5 mg are available in an Alu-PVC blister of 10 tablets. Such 03 blisters in a unit carton with package insert.
Contact us directly to receive full information on the product, the formulation, the science behind it, stability data, and more. Our Business Development Manager is a click away.
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A pharma CMO is a special kind of an organization, offering contract manufacturing services to pharmaceutical companies for various kinds of drug formulations.
Reduce overall costs and time to market :
Contract manufacturers already have the needed infrastructure and technical staff, so working with a CMO or CDMO can decrease the cost of manufacturing your pharmaceutical products.
Scalability and flexible production capacity :
You can produce what you need when you need it without worrying about excess capacity. Additionally, CMOs understand the importance of quality and compliance, so you don't have to sacrifice safety for scalability.
Save on upgrading and maintaining equipment :
If you have your manufacturing facility, you’ll have to pay to upgrade your equipment as technology advances—which can get expensive. A CMO/CDMO’s only function is to make and distribute products, so part of their core business responsibility is to update their equipment whenever needed and perform maintenance.
Ease supply chain issues :
During the pandemic, there were several instances of supply chain issues, including medicine shortages. CMOs are generally better equipped than startups to handle a supply chain crisis.
Bandwidth to focus on core competencies
When your company resources aren’t directly allocated to manufacturing and distribution, you have more time to focus on other tasks, like marketing your new drug, researching, or working on drug discovery.
We have 7+ manufacturing sites with a minimum of WHO GMP certification and other country-specific approvals like NAFDAC approved, PPK Kenya Approved, TFDA Tanzania Approved, EU-GMP Approved.
We have below manufacturing capacity:
For Tablet, Capsule, and soft gel: up to 1 million units per shift
For Syrup: up to 0.05 Million per shift
For Ampoule and Vial: up to 0.1 million units per shift
For Ointment and Cream: up to 0.1 million units per shift
For Suppository: 0.1 Million units per shift
