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What Is Ceftriaxone & Tazobactam Injection 1125 mg Used For?
Ceftriaxone & Tazobactam Injection 1125 mg is a powerful combination antibiotic used to treat a wide range of bacterial infections, especially when resistance to other antibiotics is a concern.
How It Works
Together, they offer strong protection against resistant bacteria and are especially useful in hospital settings.
Common Uses
Respiratory Tract Infections
Urinary Tract Infections (UTIs)
Skin and Soft Tissue Infections
Bone and Joint Infections
Brain and Nervous System
Bloodstream Infections
Abdominal and Pelvic Infections
Ear Infections
Surgical Prophylaxis
Typhoid Fever
Pediatric Use
Dosage Guidelines of Ceftriaxone and Tazobactam Injection 1125 mg.
Adults
Usual dose: 1125 mg (1000 mg Ceftriaxone + 125 mg Tazobactam)
How often: Once a day or split into two doses (every 12 hours)
Maximum daily dose: Should not exceed 4 grams of ceftriaxone.
Before Surgery (Surgical Prophylaxis)
Dose: 1 gram IV
Timing: 30 minutes to 2 hours before surgery.
Duration of Treatment
Continue for at least 2 days after symptoms disappear.
Typical course: 4 to 14 days.
Complicated infections may need longer treatment.
Streptococcal infections: Treat for at least 10 days.
Pediatric Patients
Serious infections: 50–75 mg/kg/day (based on ceftriaxone), divided every 12 hours.
Maximum daily dose: Should not exceed 2 grams of ceftriaxone.
Ear infections (acute otitis media): One-time IM dose of 50 mg/kg (max 1 gram)
Directions for Use
Intravenous (IV) Injection.
Inject slowly over 2–4 minutes.
Intravenous (IV) Infusion
Infuse for over 30 minutes.
Intramuscular (IM) Injection.
Use a deep IM injection.
If the dose is more than 1 gram, split it and inject it into two different sites.
How to Prepare the Injection.
Mix with one of the following:
Sterile Water for Injection.
Normal Saline
Dextrose Solution (5% or 10%)
Use the solution immediately after mixing to ensure safety and effectiveness
Side Effects of Ceftriaxone-Tazobactam Injection 1125 mg.
Common Local Reactions (≈1%): Injection area pain, induration (hardening), and soreness.
Seldom (<1%): Following IV injection, phlebitis (vein inflammation)2.
Common Hypersensitivity Reactions 1.7%: Rash5
Seldom (<1%): Edema, urticaria, fever, chills, pruritus, and allergic dermatitis.
Extremely Seldom (<0.1%): severe skin reactions, such as.
Multiform erythema
The Stevens-Johnson syndrome.
Lyell’s syndrome, also known as toxic epidermal necrolysis.
Common Hematologic Effects:
Six percent eosinophilia
5.1% thrombocytosis
Leukopenia (2.1%).
Seldom (<1%):
Hemolytic anemia and anemia
Lymphopenia and neutropenia
Thrombocytopenia
extended time for prothrombin
Common Gastrointestinal Effects (2.7%): Having diarrhea.
Rare (<1%): stomatitis, glossitis, dysgeusia (changed taste), nausea, and vomiting
Common Hepatic Effects:
SGOT was elevated (3.1%).
SGPT was elevated (3.3%).
Seldom (<1%): Increased bilirubin and alkaline phosphatase
Common Renal Effects (1.2%): Increased BUN
Rare (<1%): Nephrolithiasis, oliguria, urine casts, and elevated creatinine
The central nervous system
Seldom (<1%): seizures, headaches, and lightheadedness.
Rare (<1%) genitourinary effects: Vaginitis and moniliasis (yeast infection)
Miscellaneous
Rare (<1%): flushing and diaphoresis
Extremely Rare (<0.1%):
Flatulence, dyspepsia, colitis, and pain in the abdomen
Palpitations with epistaxis (nosebleed)
Allergic pneumonitis with serum sickness
stones, gallbladder sludge, or hepatitis
Hematuria with glycosuria
Monocytosis, leukocytosis, and lymphocytosis
Prothrombin duration decrease
Precipitations in the kidneys
Notes: The majority of adverse effects are minor and resolve on their own.
Monitoring closely is necessary for severe hypersensitivity responses, hematologic issues, and renal or liver dysfunction.
Local responses can be affected by injection technique and formulation (e.g., osmolality, pH)10.
Precautions While Taking Ceftriaxone-Tazobactam Injection 1125 mg
Allergy Warning
Diarrhea Risk
Blood-Related Issues
Kidney Health
Liver Health
Blood Clotting (Prothrombin Time)
Gallbladder and Pancreas
Children
Store below 30°C temperature. Protect from light.
Keep the medicine out of reach of children.
10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal.
Ceftriaxone & Tazobactam Injection 1125 mg in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections USP in a unit carton with a pack insert.
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A pharma CMO is a special kind of an organization, offering contract manufacturing services to pharmaceutical companies for various kinds of drug formulations.
Reduce overall costs and time to market :
Contract manufacturers already have the needed infrastructure and technical staff, so working with a CMO or CDMO can decrease the cost of manufacturing your pharmaceutical products.
Scalability and flexible production capacity :
You can produce what you need when you need it without worrying about excess capacity. Additionally, CMOs understand the importance of quality and compliance, so you don't have to sacrifice safety for scalability.
Save on upgrading and maintaining equipment :
If you have your manufacturing facility, you’ll have to pay to upgrade your equipment as technology advances—which can get expensive. A CMO/CDMO’s only function is to make and distribute products, so part of their core business responsibility is to update their equipment whenever needed and perform maintenance.
Ease supply chain issues :
During the pandemic, there were several instances of supply chain issues, including medicine shortages. CMOs are generally better equipped than startups to handle a supply chain crisis.
Bandwidth to focus on core competencies
When your company resources aren’t directly allocated to manufacturing and distribution, you have more time to focus on other tasks, like marketing your new drug, researching, or working on drug discovery.
We have 7+ manufacturing sites with a minimum of WHO GMP certification and other country-specific approvals like NAFDAC approved, PPK Kenya Approved, TFDA Tanzania Approved, EU-GMP Approved.
We have below manufacturing capacity:
For Tablet, Capsule, and soft gel: up to 1 million units per shift
For Syrup: up to 0.05 Million per shift
For Ampoule and Vial: up to 0.1 million units per shift
For Ointment and Cream: up to 0.1 million units per shift
For Suppository: 0.1 Million units per shift
Contact us directly to receive full information on the product, the formulation, the science behind it, stability data, and more. Our Business Development Manager is a click away.
Conical Pharmaceuticals is a professionally managed and dynamic organization with decades of experience in the pharmaceutical field. With a desire of providing opportunities for a better life, we work very hard to bring quality drugs to our customers. We have instilled a level of trust and confidence amongst our clients by supplying the best quality products.
