Ceftazidime and Tazobactam Injection 1.125gm

Therapeutic Class: Anti-Infectives

Dosage Forms: Injectables

Brand Name: Ceftazidime & Tazobactam Injection 1125 mg

Packaging Available In Alu/PVC Blister

Pack Size: 30x10 Softgels

Best Ceftazidime and Tazobactam Injection 1.125gm manufacturer, supplier & exporter in India.

How it works?

Uses of Ceftazidime and Tazobactam Injection 1.125gm

What are the usages of Ceftazidime and Tazobactam Injection 1125 mg

  • Ceftriaxone: Kills bacteria by stopping them from building their protective cell wall.
  • Tazobactam: Blocks enzymes that bacteria use to resist antibiotics, making ceftriaxone more effective.

Together, they offer strong protection against resistant bacteria and are especially useful in hospital settings.

Common Uses

Respiratory Tract Infections

  • Pneumonia (including hospital-acquired)
  • Bronchitis
  • Lung infections in ventilated patients

Urinary Tract Infections (UTIs)

  • Complicated UTIs
  • Kidney infections (pyelonephritis)

Skin and Soft Tissue Infections

  • Cellulitis
  • Abscesses
  • Diabetic foot infections
  • Post-surgical wound infections

Bone and Joint Infections

  • Osteomyelitis
  • Septic arthritis

Brain and Nervous System

  • Meningitis
  • Brain abscess

Bloodstream Infections

  • Sepsis
  • Bacteremia

Abdominal and Pelvic Infections.

  • Appendicitis.
  • Peritonitis.
  • Pelvic inflammatory disease.
  • Postpartum infections.

Ear Infections

  • Acute bacterial otitis media (especially in children)

Surgical Prophylaxis

  • Given before surgery to prevent infections.

Typhoid Fever

  • Used when oral antibiotics are not suitable.

Pediatric Use

  • Safe for children (except newborns with high bilirubin levels)
  • Used for serious infections and ear infections.

Dosages administration of Ceftazidime and Tazobactam Injection 1.125gm

How to Use Ceftazidime and Tazobactam Injection 1125 mg

Adults

  • Usual dose: 1125 mg (1000 mg Ceftriaxone + 125 mg Tazobactam)
  • How often: Once a day or split into two doses (every 12 hours)
  • Maximum daily dose: Should not exceed 4 grams of ceftriaxone.

Before Surgery (Surgical Prophylaxis)

  • Dose: 1 gram IV
  • When: 30 minutes to 2 hours before surgery

Duration of Treatment

  • Continue for at least 2 days after symptoms disappear
  • Typical course: 4 to 14 days
  • Complicated infections: May need longer treatment
  • Streptococcal infections: Treat for at least 10 days

Pediatric Patients

  • Serious infections: 50–75 mg/kg/day (based on Ceftriaxone), divided every 12 hours
  • Maximum daily dose: Should not exceed 2 grams of ceftriaxone.
  • Ear infections (acute otitis media): One-time IM dose of 50 mg/kg (max 1 gram)

How to Give the Injection

Intravenous (IV) Injection

  • Inject slowly over 2–4 minutes

Intravenous (IV) Infusion

  • Infuse for over 30 minutes.

Intramuscular (IM) Injection.

  • Use a deep IM injection.
  • If the dose is more than 1 gram, split it and inject it into two different sites.

How to Prepare the Injection

  • Reconstitute (mix) with:
    • Sterile Water for Injection.
    • Normal Saline.
    • Dextrose Solution (5% or 10%)
  • Use the solution immediately after mixing to ensure safety and effectiveness.

Side effects of Ceftazidime and Tazobactam Injection 1.125gm

Side Effects of Ceftazidime and Tazobactam Injection 1.125 gm.
Local Reactions at the Site of Injection
Typical (≈1%): Tenderness, swelling (hardening), and pain
Rarely (<0.1%): Following IV injection, pneumonia (vein inflammation).
Intolerance Responses
Moderate 1.7%: Rash Rare (less than 1%): temperature, chills, and pruritus (itching)
Anaphylaxis, allergic pneumonitis, serum sickness, and serious skin responses (such as toxic epidermal necrolysis and Stevens-Johnson syndrome) are extremely uncommon (<0.1%).
Hematologic (relating to blood)
Typical:
Six percent eosinophilia
5.1% thrombocytosis
Leukopenia (2.1%).
Anemia, hemolytic anemia, lymphopenia, neutropenia, thrombocytopenia, and extended prothrombin time are uncommon (<1%).
gastrointestinal
Typical (2.7%): Diarrhea 8
Abdominal pain, flatulence, stomatitis, glossitis, colitis, nausea, vomiting, and dysgeusia (taste disturbance) are uncommon (<1%).
Hepatic (relating to the liver)
Typical:
SGOT was elevated (3.1%).
3.3% elevated SGPT are less than 1%. Increased bilirubin, jaundice, and alkaline phosphatase
Renal (relating to the kidneys)
Typical (1.2%): Increased BUN
Seldom (<1%): increased creatinine, nephrolithiasis, hematuria, urinary casts,
Rare (<1%) symptoms of the central nervous system include headache, vertigo, and seizures.
Genitourinary Rare (<1%): oliguria, vaginitis, and moniliasis (yeast infection)
Rare (<1%) dermatological conditions include urticaria, edema, allergic dermatitis, and exanthema.
Severe cutaneous responses, such as Stevens-Johnson syndrome and erythema multiforme, are extremely uncommon (<0.1%).
Other
Rare (<1%): flushing and diaphoresis
Palpitations, epistaxis (nosebleed), glycosuria, lymphocytosis, monocytosis, basophilia, gallbladder sludge, and biliary lithiasis are all extremely uncommon (<0.1%).

Precautions of Ceftazidime and Tazobactam Injection 1.125gm

Precautions You Should Know Before Taking Ceftazidime and Tazobactam Injection 1.125gm.

Allergies

  • If you’re allergic to penicillin or cephalosporins, tell your doctor before starting this medicine.
  • Serious allergic reactions (like swelling, breathing trouble, or rash) may need emergency treatment with epinephrine.
  • Stop the medicine and seek help immediately if you notice any signs of an allergic reaction.

Diarrhoea Warning

  • This medicine can cause Clostridium difficile-associated diarrhea, which may be mild or life-threatening.
  • If you get severe or long-lasting diarrhea, even weeks after stopping the medicine, contact your doctor right away.

Blood-Related Issues

  • Rarely, this medicine may cause immune-related anemia (your body attacks its own red blood cells).
  • If you feel unusually tired or dizzy or notice pale skin, tell your doctor. They may stop the medicine and run tests.

Kidney Health

  • This medicine is cleared through the kidneys and bile.
  • Most patients with kidney problems don’t need a dose change, but your doctor may monitor your blood levels.
  • If the drug builds up in your body, the dose may be reduced.

Liver Health

  • Usually, no dose change is needed for liver problems.
  • But if you have both liver and kidney issues, your dose should not exceed 2 grams per day unless your doctor is closely monitoring you.

Blood Clotting (Prothrombin Time)

  • This medicine may affect blood clotting in people with:
    • Liver disease
    • Poor nutrition
    • Low vitamin K levels
  • Your doctor may check your prothrombin time and give vitamin K if needed.

Gallbladder and Pancreas

  • Some patients may develop gallbladder issues or pancreatitis (inflammation of the pancreas).
  • These problems usually go away after stopping the medicine.
  • Let your doctor know if you feel abdominal pain, nausea, or vomiting.

Children

  • Use with caution in children with high bilirubin levels (especially newborns).
  • Not enough data is available for children with kidney or liver problems, so doctors will decide carefully.

Storage instruction of Ceftazidime and Tazobactam Injection 1.125gm

Store below 30°C temperature. Protect from light.

Keep the medicine out of reach of children.

Packing details of Ceftazidime and Tazobactam Injection 1.125gm

10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal.

Ceftriaxone & Tazobactam Injection 1125 mg in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections USP in a unit carton with a pack insert.

F. A. Q

Frequently Asked Questions

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Bandwidth to focus on core competencies
When your company resources aren’t directly allocated to manufacturing and distribution, you have more time to focus on other tasks, like marketing your new drug, researching, or working on drug discovery.

We have 7+ manufacturing sites with a minimum of WHO GMP certification and other country-specific approvals like NAFDAC approved, PPK Kenya Approved, TFDA Tanzania Approved, EU-GMP Approved.

We have below manufacturing capacity:
For Tablet, Capsule, and soft gel: up to 1 million units per shift
For Syrup: up to 0.05 Million per shift
For Ampoule and Vial: up to 0.1 million units per shift
For Ointment and Cream: up to 0.1 million units per shift
For Suppository: 0.1 Million units per shift

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