Ceftazidime Injection 1gm

Therapeutic Class: Anti-Infectives

Dosage Forms: Injectables

Brand Name: Ceftazidime For Injection USP 1000 mg

How it works?

Uses of Ceftazidime Injection 1gm

What are the uses of Ceftazidime Injection 1gm?

Ceftazidime Injection 1gm inhibits bacterial cell wall synthesis following attachment to penicillin-binding proteins (PBPs). This results in the interruption of cell wall (peptidoglycan) biosynthesis, which leads to bacterial cell lysis and death.

Dosages administration of Ceftazidime Injection 1gm

Dosages of Ceftazidime Injection 1gm

Adults and Children Over 40 kg (about 88 lbs)

Given in Separate Doses (Intermittent)

Lung infections in cystic fibrosis: 100–150 mg per kg of body weight per day, split into 3 doses. Max: 9 g/day.
Fever with low white blood cells (febrile neutropenia): 2 g every 8 hours.
Serious infections (pneumonia, meningitis, blood infections, bone/joint infections): 1–2 g every 8 hours.
Complicated urine infections: 1–2 g every 8–12 hours.
Before prostate surgery (TURP): 1 g at the start of anesthesia and 1 g when the catheter is removed.
Ear infections (chronic or severe): 1–2 g every 8 hours.

Given All Day Through a Drip (Continuous Infusion)

Serious infections: Start with 2 g, then give 4–6 g slowly over 24 hours.

Children Under 40 kg

Given in Separate Doses

Most serious infections: 100–150 mg per kg per day, split into 3 doses. Max: 6 g/day.
Low white blood cells (neutropenia): 150 mg/kg/day in 3 doses.
Urine, ear, lung, bone, joint, and skin infections: Same as above.

Given All Day Through a Drip

Serious infections: Start with 60–100 mg/kg, then give 100–200 mg/kg/day slowly over 24 hours. Max: 6 g/day.

Newborns and Babies Under 2 Months

Most infections: 25–60 mg/kg/day, split into 2 doses.

Giving Ceftazidime Injection 1gm slowly all day (continuous infusion) is not recommended for babies under 2 months.

Older Adults (Over 80 Years)

Because kidneys work slower with age, the dose should not be more than 3 g per day.

Liver Problems

No dose change needed for mild or moderate liver issues.

For serious liver problems, the doctor will monitor closely.

Kidney Problems

Adults and Children Over 40 kg

Kidney Function	Dose	How Often
Mild (50–31 ml/min)	1 g	Every 12 hours
Moderate (30–16 ml/min)	1 g	Every 24 hours
Severe (15–6 ml/min)	0.5 g	Every 24 hours
Very severe (<5 ml/min)	0.5 g	Every 48 hours

Start with 1 g as a loading dose. For serious infections, the doctor may increase the dose or give it more often.

Children Under 40 kg

Kidney Function	Dose (mg/kg)	How Often
Mild (50–31 ml/min)	25	Every 12 hours
Moderate (30–16 ml/min)	25	Every 24 hours
Severe (15–6 ml/min)	12.5	Every 24 hours
Very severe (<5 ml/min)	12.5	Every 48 hours

Dialysis Patients

Haemodialysis

After each dialysis session, repeat the dose based on kidney function.

Peritoneal Dialysis (CAPD)

Can be given in IV form or added to dialysis fluid (125–250 mg per 2 liters of fluid).

Haemofiltration (CVVH or CVVHD)

Dose depends on how much fluid is filtered and kidney function.
Usually given every 12 hours.

Side effects of Ceftazidime Injection 1gm

Possible Side Effects of Ceftazidime Injection 1gm

Ceftazidime Injection 1gm may cause side effects in some people. These can range from mild to serious. Below is a summary of known side effects, grouped by how often they happen and which part of the body they affect.

Frequency Guide

Very common: affects more than 1 in 10 people
Common: affects 1 in 100 to 1 in 10 people
Uncommon: affects 1 in 1,000 to 1 in 100 people
Rare: affects 1 in 10,000 to 1 in 1,000 people
Very rare: affects fewer than 1 in 10,000 people
Unknown: frequency not known

Infections

Uncommon: Yeast infections (e.g. oral thrush, vaginal candidiasis)

Blood Disorders

Common: High eosinophil count, high platelet count
Uncommon: Low white blood cells, low neutrophils, low platelets
Very rare: Severe drop in white blood cells, destruction of red blood cells
Unknown: High lymphocyte count

Immune System

Unknown: Severe allergic reaction (anaphylaxis), may include breathing difficulty or low blood pressure

Nervous System

Uncommon: Headache, dizziness
Unknown: Tingling sensation, serious neurological symptoms (especially in patients with kidney problems)

Veins

Common: Pain or inflammation at the injection site (especially with IV use)

Digestive System

Common: Diarrhoea
Uncommon: Abdominal pain, nausea, vomiting
Unknown: Bad taste, serious gut infection (Clostridioides difficile)

Liver

Common: Temporary rise in liver enzymes (ALT, AST, GGT, etc.)
Unknown: Yellowing of skin or eyes (jaundice)

Skin

Common: Rash (maculopapular or hives)
Uncommon: Itching
Unknown: Serious skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, angioedema)

Kidneys

Uncommon: Temporary rise in kidney markers (urea, creatinine)
Unknown: Kidney inflammation or failure

General Symptoms

Common: Pain or swelling after injection
Uncommon: Fever

Lab Tests

Common: Positive Coombs’ test (may affect blood matching)

Precautions of Ceftazidime Injection 1gm

Precautions While Using Ceftazidime Injection 1gm

1. Allergic Reactions (Hypersensitivity)

Some people may have serious or even life-threatening allergic reactions to Ceftazidime Injection 1gm or similar antibiotics (like penicillins or cephalosporins).
If you experience symptoms like rash, swelling, difficulty breathing, or severe itching, stop the medicine immediately and seek emergency help.
Before starting treatment, tell your doctor if you’ve ever had an allergic reaction to antibiotics.

2. Limited Effectiveness

Ceftazidime Injection 1gm works against specific bacteria. It may not be effective for all infections.
It should only be used when the bacteria causing the infection are known or strongly suspected to respond to this medicine.
It may not be suitable for serious infections like meningitis, skin infections, or bone infections unless confirmed by your doctor.

3. Diarrhoea and Colitis

Some antibiotics, including Ceftazidime Injection 1gm, can cause a serious gut condition called pseudomembranous colitis.
If you develop diarrhea during or after treatment, inform your doctor immediately.
Do not take medicines that slow down your gut unless advised by a healthcare professional.

4. Kidney Health

Ceftazidime is removed from the body through the kidneys.
If you have kidney problems, your dose may need to be adjusted.
Using it with other kidney-affecting medicines (like aminoglycosides or strong diuretics) may increase the risk of kidney damage.
People with kidney issues should be monitored closely during treatment.

5. Overgrowth of Other Germs

Using ceftazidime for a long time may allow other germs (like fungi or resistant bacteria) to grow.
Your doctor may stop or change your treatment if this happens.

6. Lab Test Interference

Ceftazidime may affect some lab test results:
- It can cause false positives in certain sugar tests (like Benedict’s or Clinitest).
- It may interfere with blood matching tests (Coombs’ test) in some patients.

7. Sodium Content

Each vial contains 50 mg of sodium.
If you’re on a low-sodium diet, this should be considered.
The sodium in the liquid used to mix the medicine also adds to the total amount—check with your pharmacist or doctor.

Storage instruction of Ceftazidime Injection 1gm

Store below 30°C temperature. Protect from light.

Keep the medicine out of reach of children.

Packing details of Ceftazidime Injection 1gm

10 ml clear glass vial with a bromobutyl rubber stopper, sealed with a flip-off aluminum seal.

Ceftazidime Injection 1gm in glass vial is supplied with 10 ml plastic ampoule of diluent (Sterilized Water for Injections USP) in unit carton with pack insert

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