Ceftazidime Injection 1gm
Ceftazidime For Injection USP 1000 mg
Therapeutic Class: Anti-Infectives
Dosage Forms: Injectables
Brand Name: Ceftazidime For Injection USP 1000 mg™
How it works?
Uses of Ceftazidime Injection 1gm
What are the uses of Ceftazidime Injection 1gm?
Ceftazidime Injection 1gm inhibits bacterial cell wall synthesis following attachment to penicillin-binding proteins (PBPs). This results in the interruption of cell wall (peptidoglycan) biosynthesis, which leads to bacterial cell lysis and death.
Precautions of Ceftazidime Injection 1gm
Precautions While Using Ceftazidime Injection 1gm
1. Allergic Reactions (Hypersensitivity)
- Some people may have serious or even life-threatening allergic reactions to Ceftazidime Injection 1gm or similar antibiotics (like penicillins or cephalosporins).
- If you experience symptoms like rash, swelling, difficulty breathing, or severe itching, stop the medicine immediately and seek emergency help.
- Before starting treatment, tell your doctor if you’ve ever had an allergic reaction to antibiotics.
2. Limited Effectiveness
- Ceftazidime Injection 1gm works against specific bacteria. It may not be effective for all infections.
- It should only be used when the bacteria causing the infection are known or strongly suspected to respond to this medicine.
- It may not be suitable for serious infections like meningitis, skin infections, or bone infections unless confirmed by your doctor.
3. Diarrhoea and Colitis
- Some antibiotics, including Ceftazidime Injection 1gm, can cause a serious gut condition called pseudomembranous colitis.
- If you develop diarrhea during or after treatment, inform your doctor immediately.
- Do not take medicines that slow down your gut unless advised by a healthcare professional.
4. Kidney Health
- Ceftazidime is removed from the body through the kidneys.
- If you have kidney problems, your dose may need to be adjusted.
- Using it with other kidney-affecting medicines (like aminoglycosides or strong diuretics) may increase the risk of kidney damage.
- People with kidney issues should be monitored closely during treatment.
5. Overgrowth of Other Germs
- Using ceftazidime for a long time may allow other germs (like fungi or resistant bacteria) to grow.
- Your doctor may stop or change your treatment if this happens.
6. Lab Test Interference
- Ceftazidime may affect some lab test results:
- It can cause false positives in certain sugar tests (like Benedict’s or Clinitest).
- It may interfere with blood matching tests (Coombs’ test) in some patients.
7. Sodium Content
- Each vial contains 50 mg of sodium.
- If you’re on a low-sodium diet, this should be considered.
- The sodium in the liquid used to mix the medicine also adds to the total amount—check with your pharmacist or doctor.
Dosages administration of Ceftazidime Injection 1gm
Dosages of Ceftazidime Injection 1gm
Adults and Children Over 40 kg (about 88 lbs)
Given in Separate Doses (Intermittent)
- Lung infections in cystic fibrosis: 100–150 mg per kg of body weight per day, split into 3 doses. Max: 9 g/day.
- Fever with low white blood cells (febrile neutropenia): 2 g every 8 hours.
- Serious infections (pneumonia, meningitis, blood infections, bone/joint infections): 1–2 g every 8 hours.
- Complicated urine infections: 1–2 g every 8–12 hours.
- Before prostate surgery (TURP): 1 g at the start of anesthesia and 1 g when the catheter is removed.
- Ear infections (chronic or severe): 1–2 g every 8 hours.
Given All Day Through a Drip (Continuous Infusion)
- Serious infections: Start with 2 g, then give 4–6 g slowly over 24 hours.
Children Under 40 kg
Given in Separate Doses
- Most serious infections: 100–150 mg per kg per day, split into 3 doses. Max: 6 g/day.
- Low white blood cells (neutropenia): 150 mg/kg/day in 3 doses.
- Urine, ear, lung, bone, joint, and skin infections: Same as above.
Given All Day Through a Drip
- Serious infections: Start with 60–100 mg/kg, then give 100–200 mg/kg/day slowly over 24 hours. Max: 6 g/day.
Newborns and Babies Under 2 Months
- Most infections: 25–60 mg/kg/day, split into 2 doses.
Giving Ceftazidime Injection 1gm slowly all day (continuous infusion) is not recommended for babies under 2 months.
Older Adults (Over 80 Years)
- Because kidneys work slower with age, the dose should not be more than 3 g per day.
Liver Problems
- No dose change needed for mild or moderate liver issues.
For serious liver problems, the doctor will monitor closely.
Kidney Problems
Adults and Children Over 40 kg
| Kidney Function | Dose | How Often |
|---|---|---|
| Mild (50–31 ml/min) | 1 g | Every 12 hours |
| Moderate (30–16 ml/min) | 1 g | Every 24 hours |
| Severe (15–6 ml/min) | 0.5 g | Every 24 hours |
| Very severe (<5 ml/min) | 0.5 g | Every 48 hours |
Start with 1 g as a loading dose. For serious infections, the doctor may increase the dose or give it more often.
Children Under 40 kg
| Kidney Function | Dose (mg/kg) | How Often |
|---|---|---|
| Mild (50–31 ml/min) | 25 | Every 12 hours |
| Moderate (30–16 ml/min) | 25 | Every 24 hours |
| Severe (15–6 ml/min) | 12.5 | Every 24 hours |
| Very severe (<5 ml/min) | 12.5 | Every 48 hours |
Dialysis Patients
Haemodialysis
- After each dialysis session, repeat the dose based on kidney function.
Peritoneal Dialysis (CAPD)
- Can be given in IV form or added to dialysis fluid (125–250 mg per 2 liters of fluid).
Haemofiltration (CVVH or CVVHD)
- Dose depends on how much fluid is filtered and kidney function.
- Usually given every 12 hours.
Side effects of Ceftazidime Injection 1gm
Possible Side Effects of Ceftazidime Injection 1gm
Ceftazidime Injection 1gm may cause side effects in some people. These can range from mild to serious. Below is a summary of known side effects, grouped by how often they happen and which part of the body they affect.
Frequency Guide
- Very common: affects more than 1 in 10 people
- Common: affects 1 in 100 to 1 in 10 people
- Uncommon: affects 1 in 1,000 to 1 in 100 people
- Rare: affects 1 in 10,000 to 1 in 1,000 people
- Very rare: affects fewer than 1 in 10,000 people
- Unknown: frequency not known
Infections
- Uncommon: Yeast infections (e.g. oral thrush, vaginal candidiasis)
Blood Disorders
- Common: High eosinophil count, high platelet count
- Uncommon: Low white blood cells, low neutrophils, low platelets
- Very rare: Severe drop in white blood cells, destruction of red blood cells
- Unknown: High lymphocyte count
Immune System
- Unknown: Severe allergic reaction (anaphylaxis), may include breathing difficulty or low blood pressure
Nervous System
- Uncommon: Headache, dizziness
- Unknown: Tingling sensation, serious neurological symptoms (especially in patients with kidney problems)
Veins
- Common: Pain or inflammation at the injection site (especially with IV use)
Digestive System
- Common: Diarrhoea
- Uncommon: Abdominal pain, nausea, vomiting
- Unknown: Bad taste, serious gut infection (Clostridioides difficile)
Liver
- Common: Temporary rise in liver enzymes (ALT, AST, GGT, etc.)
- Unknown: Yellowing of skin or eyes (jaundice)
Skin
- Common: Rash (maculopapular or hives)
- Uncommon: Itching
- Unknown: Serious skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, angioedema)
Kidneys
- Uncommon: Temporary rise in kidney markers (urea, creatinine)
- Unknown: Kidney inflammation or failure
General Symptoms
- Common: Pain or swelling after injection
- Uncommon: Fever
Lab Tests
- Common: Positive Coombs’ test (may affect blood matching)
Storage instruction of Ceftazidime Injection 1gm
Store below 30°C temperature. Protect from light.
Keep the medicine out of reach of children.
Packing details of Ceftazidime Injection 1gm
10 ml clear glass vial with a bromobutyl rubber stopper, sealed with a flip-off aluminum seal.
Ceftazidime Injection 1gm in glass vial is supplied with 10 ml plastic ampoule of diluent (Sterilized Water for Injections USP) in unit carton with pack insert
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Yes, we are the manufacturer and exporter of Ceftazidime Injection 1 g. Our GMP‑certified facilities follow strict quality protocols to ensure consistent, safe, and compliant production for global healthcare markets.
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