Cefpirome with Sulphate Injection 1000 mg

Therapeutic Class: Anti-Infectives

Dosage Forms: Injectables

Brand Name: Cefpirome Sulphate Injection IH 1000 mg

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Uses of Cefpirome with Sulphate Injection 1000 mg

Uses of Cefpirome with Sulphate Injection 1000 mg

Respiratory Tract Infections.

  • Pneumonia.
  • Lower respiratory infections.

Urinary Tract Infections

  • Complicated UTIs.
  • Pyelonephritis (kidney infection)

Bloodstream Infections

  • Septicemia.
  • Bacteremia.

Infections in Immunocompromised Patients.

  • Especially useful in neutropenic patients (e.g., those undergoing chemotherapy)

Skin and Soft Tissue Infections.

  • Cellulitis, abscesses, and wound infections.

Bone and Joint Infections

  • Osteomyelitis and septic arthritis.

Intra-abdominal and Genital Infections.

  • Peritonitis, pelvic infections.

Surgical Prophylaxis

  • Used to prevent infections after surgery.

Cefpirome with Sulphate Injection 1000 mg is not effective against viral infections like the flu or the common cold. It is typically administered in hospitals via intravenous or intramuscular injection, and its use in children under 12 is limited due to insufficient data.

Dosages administration of Cefpirome with Sulphate Injection 1000 mg

Cefpirome with Sulphate Injection 1000 mg Dosage & Administration Guide

Depends On:

  • Severity of the infection
  • Type of bacteria causing the infection
  • Patient’s age, weight, and kidney function

Adults (with normal kidney function)

  • Usual dose: 1–2 grams every 12 hours
  • Route: Intravenous (IV) or Intramuscular (IM)

Elderly Patients

  • No dose change needed unless kidney function is reduced

Children

  • Dose: 50 mg per kg of body weight.
  • Frequency: Every 8 to 12 hours.
  • Note: Not recommended for children under 12 due to limited data.

Patients with Kidney Problems

  • Cefpirome is cleared through the kidneys, so
    • Dose must be reduced if kidney function is poor.
    • Your doctor will adjust the dose based on creatinine clearance.

Duration of Treatment

  • Depends on how well the patient responds to treatment.
  • Your doctor will decide when to stop.

How to Prepare and Give Cefpirome with Sulphate Injection 1000 mg

Intravenous Injection (IV Push)

  • 1g vial dissolved in 10 ml sterile water.
  • Inject slowly over 3–5 minutes.

Short IV Infusion

  • 1g vial dissolved in 100 ml of
    • Sterile water.
    • 0.9% sodium chloride (saline)
    • Ringer’s solution.
    • 5% or 10% glucose.
    • 5% fructose.
    • 6% glucose + 0.9% saline.
  • Infuse over 20–30 minutes.
  • Do not use sodium bicarbonate solution

Handling Tips

  • Tilt the vial gently for 1 minute to dissolve (foaming is normal)
  • Use aseptic technique to avoid infection.
  • Use the solution immediately after preparation.
  • If stored:
    • Up to 6 hours at room temperature.
    • Up to 24 hours in the fridge (2°C to 8°C)
  • Protect from sunlight.

Side effects of Cefpirome with Sulphate Injection 1000 mg

Hypersensitivity Reaction Side Effects of  Cefpirome with Sulphate Injection 1000 mg.

Skin and Allergic Reactions.

  • Rash and urticaria (hives)
  • Itching.
  • Drug-induced fever.
  • Severe acute allergic reactions (anaphylaxis)

These are typically type I hypersensitivity reactions, mediated by IgE antibodies, and can range from mild skin irritation to life-threatening anaphylaxis.

Neurological and Sensory Effects.

  • Headache.
  • Disturbance of taste.
  • Convulsions (very rare)

These may result from systemic immune activation or direct drug effects on the nervous system.

Gastrointestinal Effects

  • Nausea and vomiting.
  • Abdominal pain.
  • Diarrhoea.
  • Pseudomembranous colitis (very rare, associated with Clostridium difficile overgrowth)

Liver Function Alterations

  • Elevated liver enzymes: ASAT, ALAT, LDH, alkaline phosphatase.
  • Increased serum bilirubin

These may indicate drug-induced liver injury, often reversible upon discontinuation.

Renal Function Changes

  • Increased serum creatinine and urea.
  • Interstitial nephritis (rare, immune-mediated)

Renal monitoring is crucial, especially with cephalosporins, as nephrotoxicity may necessitate stopping treatment.

Hematologic Changes.

  • Thrombocytopenia.
  • Eosinophilia.
  • Hemolytic anemia (very rare)
  • Granulocytopenia and agranulocytosis (especially with prolonged beta-lactam use)

These are often Type II or Type III hypersensitivity reactions, involving antibody-mediated cell destruction or immune complex deposition.

Local Injection Site Reactions.

  • Pain.
  • Inflammatory irritation.

Common with intramuscular or intravenous administration.

Risk of Superinfection

  • Proliferation of resistant microorganisms, especially with prolonged antibiotic use.

Regular monitoring is essential to detect emerging resistance or secondary infections.

Precautions of Cefpirome with Sulphate Injection 1000 mg

Important Precautions for Cefpirome with Sulphate Injection 1000 mg

Allergies

  • Stop treatment immediately if you experience any allergic reaction (rash, itching, swelling, or breathing difficulty).
  • Tell your doctor if you’re allergic to penicillin—about 5–10% of people allergic to penicillin may also react to cephalosporins like Cefpirome.
  • Never take cefpirome if you’ve had a serious reaction to cephalosporins before.

Kidney Health

  • Monitor kidney function during treatment, especially if you’re also taking.
    • Diuretics like furosemide or ethacrynic acid
    • Other antibiotics like aminoglycosides (which can harm the kidneys)
  • If you have kidney problems, your doctor will adjust the dose based on your creatinine clearance.

Blood Tests

  • Long-term use (more than 10 days) may affect your white blood cells.
  • Your doctor may order regular blood tests to check for conditions like granulocytopenia or agranulocytosis.

Severe Diarrhoea Warning

  • If you get severe or long-lasting diarrhea during or after treatment, tell your doctor immediately.
  • It could be a sign of pseudomembranous colitis, a serious gut infection caused by Clostridium difficile.
  • Stop cefpirome immediately if this is suspected.
  • Do not take anti-diarrhea medicines unless your doctor says it’s safe.

Use in Children

  • Not enough studies have been done in children.
  • Cefpirome is not recommended for use in children under 12 years.

Storage instruction of Cefpirome with Sulphate Injection 1000 mg

Store below 30°C temperature. Protect from light.

Keep the medicine out of reach of children.

 

Packing details of Cefpirome with Sulphate Injection 1000 mg

10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal.

Cefpirome with Sulphate Injection 1000 mg in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections USP in a unit carton with a pack insert.

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About Conical Pharmaceuticals

Conical Pharmaceuticals is a professionally managed and dynamic organization with decades of experience in the pharmaceutical field. With a desire of providing opportunities for a better life, we work very hard to bring quality drugs to our customers. We have instilled a level of trust and confidence amongst our clients by supplying the best quality products.

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