Cefoperazone and Sulbactam Injection 1000 mg

Therapeutic Class: Anti-Infectives

Dosage Forms: Injectables

Brand Name: Cefoperazone & Sulbactam Injection 1000 mg

Best Cefoperazone and Sulbactam Injection 1000 mg Manufacturer, Supplier & Exporter in India.

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Uses of Cefoperazone and Sulbactam Injection 1000 mg

Uses Of Cefoperazone and Sulbactam Injection 1000 mg

  • Cefoperazone: A strong antibiotic that fights a wide range of bacteria.
  • Sulbactam: Protects cefoperazone from bacterial enzymes that try to destroy it, making the treatment more effective.

Dosages administration of Cefoperazone and Sulbactam Injection 1000 mg

Dosages Of Cefoperazone and Sulbactam Injection 1000 mg

  • Available as dry powder in vials for injection only
  • Two ratio options:
    • 1:1 = 500 mg + 500 mg or 1000 mg + 1000 mg
    • 1:2 = 500 mg + 1000 mg or 1000 mg + 2000 mg (Sulbactam + Cefoperazone)

Adult Dosage

  • Usual dose: 2 to 4 g per day, divided every 12 hours (i.e., 1–2 g cefoperazone daily)
  • Max sulbactam dose: 4 g/day.
  • For febrile neutropenia, doses may be split into 2–3 times a day.

Patients with Kidney Issues (Renal Dysfunction)

Creatinine Clearance Max Sulbactam Dose
15–30 ml/min 1 g every 12 hrs (max 2 g/day)
<15 ml/min 500 mg every 12 hrs (max 1 g/day)
  • May need extra cefoperazone if infection is severe.
  • Dialysis patients: Schedule doses after dialysis.

Side effects of Cefoperazone and Sulbactam Injection 1000 mg

Most Common Side Effects of Cefoperazone and Sulbactam Injection 1000 mg

These are usually mild and may go away on their own:

  • Blood changes: Low white blood cells, low red blood cells, or low platelets
  • Digestive issues: Diarrhea, nausea, vomiting
  • Liver-related: Increased liver enzymes (seen in blood tests)
  • Infusion reactions: pain, inflammation, or fever at the injection site.

Less Common or Rare Side Effects.

These may need medical attention:

  • Skin problems: itching, rashes, hives, and rare serious skin reactions like Stevens-Johnson syndrome.
  • Allergic reactions: Swelling, breathing difficulty, or severe allergy (anaphylaxis)
  • Bleeding issues: Changes in blood clotting or rare internal bleeding.
  • Kidney symptoms: Blood in urine.
  • Nervous system: Headaches.
  • Reproductive system: Itching around genitals (rare)

Precautions of Cefoperazone and Sulbactam Injection 1000 mg

Allergic Reactions (Hypersensitivity)

  • Serious and even life-threatening allergic reactions (like anaphylaxis) have been reported.
  • People with a history of allergies—especially to cephalosporins, penicillins, or other medicines—should be treated with caution.
  • Check for any past drug allergies before giving this medicine.
  • If an allergic reaction occurs:
    • Stop the medicine immediately
    • Begin emergency treatment (e.g., epinephrine, oxygen, IV steroids, airway management if needed)

Severe Skin Reactions

  • Rare but serious skin reactions like Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) have been reported.
  • Stop the medicine immediately if any serious skin symptoms appear (rash, peeling, blistering) and start proper medical care.

Liver Function Precautions

  • Cefoperazone is mainly excreted through bile, so patients with liver problems or blocked bile flow may process the drug more slowly.
  • In patients with both liver and kidney problems, the medicine may build up in the body.
  • In such cases, the dose should not exceed 2 g/day of cefoperazone, and blood levels should be closely monitored.

Pregnancy

  • Animal studies show no harm to the baby, but human data is lacking.
  • Use only if clearly necessary during pregnancy, under medical supervision.

Breastfeeding

  • Very small amounts may pass into breast milk.
  • Though risk is low, use caution and monitor both mother and baby during treatment.

Storage instruction of Cefoperazone and Sulbactam Injection 1000 mg

Store below 30°C temperature. Protect from light.

Keep the medicine out of reach of children.

Packing details of Cefoperazone and Sulbactam Injection 1000 mg

10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal.

Cefoperazone and Sulbactam Injection 1000 mg in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections USP in a unit carton with a pack insert.

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About Conical Pharmaceuticals

Conical Pharmaceuticals is a professionally managed and dynamic organization with decades of experience in the pharmaceutical field. With a desire of providing opportunities for a better life, we work very hard to bring quality drugs to our customers. We have instilled a level of trust and confidence amongst our clients by supplying the best quality products.

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  • info@conicalpharmaceuticals.com

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