Cefoperazone and Sulbactam Injection 1000 mg
Cefoperazone & Sulbactam Injection 1000 mg
Therapeutic Class: Anti-Infectives
Dosage Forms: Injectables
Brand Name: Cefoperazone & Sulbactam Injection 1000 mg™
How it works?
Uses of Cefoperazone and Sulbactam Injection 1000 mg
Cefoperazone and Sulbactam Injection 1000 mg Uses:
Cefoperazone and sulbactam injection 1000 mg is a powerful combination antibiotic designed to tackle a variety of serious bacterial infections.
It works by not only killing bacteria but also helping to prevent them from becoming resistant.
This medication is commonly prescribed for several types of infections, such as:
Our formulation is indicated for the treatment of:
- Respiratory tract infections: Pneumonia, bronchitis.
- Urinary tract infections (UTIs): Including pyelonephritis.
- Intra-abdominal infections: Peritonitis, appendicitis.
- Skin and soft tissue infections.
- Septicemia: Bloodstream infections.
- Bone and joint infections: Including osteomyelitis.
- Meningitis: Inflammation of brain and spinal cord membranes.
- Female genital tract infections: pelvic inflammatory disease, endometritis.
- Sexually transmitted infections: Gonorrhea.
Precautions of Cefoperazone and Sulbactam Injection 1000 mg
Allergic Reactions (Hypersensitivity)
- Serious and even life-threatening allergic reactions (like anaphylaxis) have been reported.
- People with a history of allergies, especially to cephalosporins, penicillins, or other medicines, should be treated with caution.
- Check for any past drug allergies before giving this medicine.
- If an allergic reaction occurs:
- Stop the medicine immediately
- Begin emergency treatment (e.g., epinephrine, oxygen, IV steroids, airway management if needed)
Severe Skin Reactions
- Rare but serious skin reactions like Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) have been reported.
- Stop the medicine immediately if any serious skin symptoms appear (rash, peeling, blistering) and start proper medical care.
Liver Function Precautions
- Cefoperazone is mainly excreted through bile, so patients with liver problems or blocked bile flow may process the drug more slowly.
- In patients with both liver and kidney problems, the medicine may build up in the body.
- In such cases, the dose should not exceed 2 g/day of cefoperazone, and blood levels should be closely monitored.
Pregnancy
- Animal studies show no harm to the baby, but human data is lacking.
- Use only if clearly necessary during pregnancy, under medical supervision.
Breastfeeding
- Very small amounts may pass into breast milk.
- Though risk is low, use caution and monitor both mother and baby during treatment.
Allergies
- Tell your doctor if you’re allergic to penicillin, cephalosporins, or any other medicines. Serious allergic reactions can happen.
Alcohol
- Don’t drink alcohol while taking this medicine and for a few days after. It can cause side effects like flushing, sweating, and a fast heartbeat.
Liver or Kidney Problems:
- If you have liver or kidney issues, use this medicine carefully. Your doctor may need to adjust the dose and monitor you closely.
Pregnancy or Breastfeeding:
- Talk to your doctor if you’re pregnant or breastfeeding. Use this medicine only if the benefits are greater than the risks.
Finish the Full Course:
- Keep taking the medicine until it’s finished, even if you feel better. Stopping early can cause the infection to come back and lead to antibiotic resistance.
Dosages administration of Cefoperazone and Sulbactam Injection 1000 mg
Dosages Of Cefoperazone and Sulbactam Injection 1000 mg
- Available as dry powder in vials for injection only
- Two ratio options:
- 1:1 = 500 mg + 500 mg or 1000 mg + 1000 mg
- 1:2 = 500 mg + 1000 mg or 1000 mg + 2000 mg (Sulbactam + Cefoperazone)
Adult Dosage
- Usual dose: 2 to 4 g per day, divided every 12 hours (i.e., 1–2 g cefoperazone daily)
- Max sulbactam dose: 4 g/day.
- For febrile neutropenia, doses may be split into 2–3 times a day.
Patients with Kidney Issues (Renal Dysfunction)
| Creatinine Clearance | Max Sulbactam Dose |
|---|---|
| 15–30 ml/min | 1 g every 12 hrs (max 2 g/day) |
| <15 ml/min | 500 mg every 12 hrs (max 1 g/day) |
- May need extra cefoperazone if infection is severe.
- Dialysis patients: Schedule doses after dialysis.
Side effects of Cefoperazone and Sulbactam Injection 1000 mg
Most Common Side Effects of Cefoperazone and Sulbactam Injection 1000 mg.
These are usually mild and may go away on their own:
- Blood changes: low white blood cells, low red blood cells, or low platelets.
- Digestive issues: Diarrhea, nausea, vomiting
- Liver-related: Increased liver enzymes (seen in blood tests)
- Infusion reactions: pain, inflammation, or fever at the injection site.
Less Common or Rare Side Effects.
These may need medical attention:
- Skin problems: itching, rashes, hives, and rare serious skin reactions like Stevens-Johnson syndrome.
- Allergic reactions: Swelling, breathing difficulty, or severe allergy (anaphylaxis)
- Bleeding issues: Changes in blood clotting or rare internal bleeding.
- Kidney symptoms: Blood in urine.
- Nervous system: Headaches.
- Reproductive system: Itching around genitals (rare)
Storage instruction of Cefoperazone and Sulbactam Injection 1000 mg
Store below 30°C temperature. Protect from light.
Keep the medicine out of reach of children.
Packing details of Cefoperazone and Sulbactam Injection 1000 mg
10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal.
Cefoperazone and Sulbactam Injection 1000 mg in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections USP in a unit carton with a pack insert.
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