Cefepime and Sulbactam Injection 1500mg
Cefepime & Sulbactam Injection 1500 mg
Therapeutic Class: Anti-Infectives
Dosage Forms: Injectables
Brand Name: Cefepime & Sulbactam Injection 1500 mg™
How it works?
Uses of Cefepime and Sulbactam Injection 1500mg
Uses of Cefepime and Sulbactam Injection 1500mg
Severe bacterial infections:
Effective against infections caused by susceptible Gram‑positive and Gram‑negative organisms.
Febrile neutropenia:
Empirical therapy in patients with fever and low white blood cell counts.
Complicated intra‑abdominal infections:
Often used with metronidazole to manage peritonitis and other abdominal infections.
Hospital‑acquired infections:
Including ventilator‑associated pneumonia, post‑surgical infections, and resistant Gram‑negative infections.
Urinary tract infections:
Particularly complicated or resistant cases.
Skin and soft tissue infections:
Used when infections are severe or resistant to standard therapy.
Gynecological and pelvic infections:
Sometimes prescribed for pelvic inflammatory disease and obstetric infections.
Central nervous system infections:
Supportive therapy in meningitis caused by Gram‑negative organisms.
Septicemia and sepsis:
Used in bloodstream infections and septic shock.
Precautions of Cefepime and Sulbactam Injection 1500mg
Precautions Before and During Use of Cefepime and Sulbactam Injection 1500mg
Infection-Related
- Only prescribe this injection when there’s a confirmed or strongly suspected bacterial infection to avoid contributing to antibiotic resistance.
Blood Clotting
- May reduce prothrombin activity, increasing bleeding risk—especially in:
- Patients with kidney or liver problems
- Those with poor nutrition
- Individuals on long-term antibiotic treatment
Lab Effects
- May cause a positive Coombs’ test, indicating changes to red blood cells.
Metabolism & Potassium
- High levels of arginine (far beyond the recommended dose) may temporarily affect blood sugar and increase potassium levels.
Genetic & Fertility Safety
- No cancer studies done in animals.
- Some lab tests showed DNA effects; others did not.
- No fertility issues were observed in animal studies at high doses.
Pregnancy & Breastfeeding
- Pregnancy: Safety is not confirmed—only use if absolutely necessary.
- Nursing mothers: The drug is present in breast milk in small amounts—use with caution.
Geriatric Use
- Safe for healthy older adults.
- Serious side effects (like confusion and seizures) can occur in elderly patients with kidney problems receiving incorrect doses.
- Dose adjustment and kidney function monitoring are critical.
Dosages administration of Cefepime and Sulbactam Injection 1500mg
Easy Guide to Dosage for Cefepime With Sulbactam Injection 1500mg
- This injection contains 1.5 grams of medicine in each vial.
- Doctors usually give it 2 or 3 times a day, depending on how bad the infection is.
- The highest daily amount is 9 grams, split into smaller doses throughout the day.
For People With Kidney Problems
- If your kidneys aren’t working well, your body may not remove the medicine properly.
- So, doctors will give you a smaller dose to keep things safe.
- To check your kidney health, doctors use blood tests (called serum creatinine) or a number called creatinine clearance.
- There’s even a simple formula doctors use to figure it out based on your age, weight, and sex.
When only serum creatinine is available, the following formula (based on the sex, weight, and age of the patient) may be used to convert this value in to creatinine clearance.
Males: Weight in (kg) x (140 – age) / 72 x Serum creatinine
Females: (0.85) x (above value)
Preparation of Solutions of Cefepime & Sulbactam Injection 1500 mg
| Single-dose vials for IV/IM administration | Amount of Diluent to be added (ml) | Approximate available volume (ml) | Approximate cefepime and sulbactam concentration (mg/ml) |
| 0.75 g (IV) | 5.0 | 5.9 | 80/40 |
| 0.75 g (IM) | 1.5 | 2.2 | 228/114 |
| 1.5 g (IV) | 10 | 11.4 | 90/43 |
| 1.5 g (IM) | 2.5 | 4.0 | 250/125 |
| 3.0 g (IV) | 10 | 12.3 | 160/80 |
Side effects of Cefepime and Sulbactam Injection 1500mg
Common side effect (seen in 1% or more patients):
- Pain, redness, or swelling at the injection site (phlebitis or inflammation)
- Skin rash
Less Common (seen in 0.1% to less than 1% of patients):
- Digestive issues like diarrhoea, nausea, vomiting, or colitis
- Fever or headache
- Fungal infections such as oral thrush (oral moniliasis) or vaginal yeast infections (vaginitis)
- Skin-related symptoms like itching (pruritus), hives (urticaria)
Possible Reactions Known with Cephalosporin Antibiotics (class effects)
These are less frequent but potentially serious and should be monitored:
- Blood-related changes: low white cells (leukopenia, neutropenia, agranulocytosis), low platelets (thrombocytopenia), anemia (aplastic, hemolytic), or bleeding issues
- Severe skin reactions: Stevens-Johnson syndrome, toxic skin peeling (toxic epidermal necrolysis), red patches or spots (erythema multiforme)
- Kidney problems: temporary or toxic renal dysfunction
- Liver issues: including blockage in bile flow (cholestasis)
- Pancytopenia: reduction in all types of blood cells.
Storage instruction of Cefepime and Sulbactam Injection 1500mg
Store below 30°C temperature. Protect from light.
Keep the medicine out of reach of children.
Packing details of Cefepime and Sulbactam Injection 1500mg
10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal.
Cefepime & Sulbactam Injection 1500 mg in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections USP in a unit carton with a pack insert.
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Renown GMP Certified Cefepime and Sulbactam Injection 1500mg Manufacturer
At Conical Pharmaceuticals, we are a trusted manufacturer of Cefepime and Sulbactam Injection 1500mg from our GMP certified facility in Ahmedabad, India. Belonging to the cephalosporin antibiotic class, this combination is widely used for hospital‑acquired infections, urinary tract infections, intra‑abdominal infections, skin and soft tissue infections, and septicemia. Its strong efficacy against multidrug‑resistant Gram‑negative bacteria makes it a highly demanded antibiotic in hospital and critical care settings.
As a reliable bulk supplier, we also provide private label contract manufacturing services, supporting large distributors, international importers, hospital procurement teams, pharmaceutical wholesalers, and healthcare brands with flexible production and packaging solutions.
We are actively planning to exports into Central America (Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama), Central Africa (Cameroon, Chad, DRC, Equatorial Guinea, Gabon, Republic of the Congo), and CIS countries (Armenia, Azerbaijan, Belarus, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Uzbekistan). At the same time, we are strengthening distribution in Ethiopia, Kenya, Uganda, Iraq, Ghana, Sri Lanka, Nigeria, UAE, Iran, Philippines, Saudi Arabia, Malaysia, United States, and Australia.
Importers benefit from complete regulatory documentation, including GMP Certificate, Free Sale Certificate, COPP, and tailored country‑specific dossiers. MOQ is offered as per buyer requirements, ensuring flexibility for tenders, bulk supply, and private label projects.
CUSTOM PACKAGING
Options available in size and style to meet your exact specifications and branding needs
SAMPLES AVAILABLE
Test before committing to bulk orders with complimentary samples for quality verification
LEAD TIME
45–60 days for timely delivery, ensuring reliable supply chain management
SHELF LIFE
Shelf Life: 24 months.
Frequently Asked Questions
Questions are useful tools, they open lines of communication; give us information; improve interactions, facilitate analysis, and many more.
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Yes. Conical Pharmaceuticals manufactures Cefepime and Sulbactam Injection 1500 mg at our GMP certified facility in Ahmedabad, India. Also We offer third‑party manufacturing and private label services, enabling distributors and innovators to launch their own brands with flexible packaging solutions.
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