Artemether and Lumefantrine Tablet
- Artemether 80mg + Lumefantrine 480mg
Therapeutic Class: Anti-Infectives
Dosage Forms: Tablets
Brand Name: Artefantrine - Forte™
How it works?
Uses of Artemether and Lumefantrine Tablet
What are the uses of Artemether and Lumefantrine Tablet?
Artemether 80 mg with Lumefantrine 480 mg Tablet is indicated for the treatment of uncomplicated cases of malaria due to Plasmodium falciparum in adults and children of 35 kg and above.
The most recent official guidelines on the appropriate use of antimalarial agents and local information on the prevalence of resistance to antimalarial drugs must be taken into consideration for deciding on the appropriateness of therapy with the tablet.
1. Treatment of Malaria (Plasmodium falciparum) This tablet is used to treat acute, uncomplicated malaria caused by Plasmodium falciparum, including strains that are resistant to other antimalarial drugs.
2. Fast Parasite Clearance Artemether acts quickly to kill malaria parasites in the blood, reducing symptoms like fever, chills, and body aches.
3. Prevents Parasite Growth & Spread Lumefantrine works by stopping the parasite from multiplying, helping to clear the infection completely.
4. Suitable for Adults & Children Recommended for both adults and children with non-severe malaria. Not used for prevention or severe cases involving the brain, lungs, or kidneys.
5. Emergency Stand-by Treatment Sometimes prescribed for travelers to malaria-endemic areas who may not have access to medical care within 24 hours of symptoms.
Precautions of Artemether and Lumefantrine Tablet
Precautions while taking Artemether and Lumefantrine Tablet
- Pregnancy: Not recommended during the first trimester if other effective antimalarial are available.
- Severe malaria: Not evaluated for cerebral malaria, pulmonary edema, or renal failure. Avoid use in severe cases unless no alternatives exist.
- Concurrent antimalarial: Should not be given with other antimalarial agents unless absolutely necessary due to limited safety data.
- Quinine administration: Lumefantrine’s long half‑life requires caution. If quinine is given afterward, close ECG monitoring is advised.
- Mefloquine: Monitor food intake closely if administered after mefloquine.
- Halofantrine: Do not administer within one month of halofantrine use.
- Drug interactions: Use cautiously with antiretroviral drugs (ARTs), as reduced drug levels may lower antimalarial efficacy.
- QT prolongation: Like other antimalarial, it may cause QT interval prolongation. ECG monitoring is recommended when combined with quinine, quinidine, or halofantrine.
- CYP3A4 interactions: Caution with drugs that inhibit or induce CYP3A4, especially HIV protease inhibitors and NNRTIs.
- Hormonal contraceptives: May reduce effectiveness; monitor closely.
- Renal/hepatic impairment: No dose adjustment needed, but caution in severe impairment. ECG and potassium monitoring are advised.
Dosages administration of Artemether and Lumefantrine Tablet
Dosage & Administration of Artemether and Lumefantrine Tablet
- Initial treatment: Begin at diagnosis or onset of malaria symptoms, ideally after a positive test.
- Adult regimen:
- One tablet twice daily for 3 days (total 6 doses).
- First dose followed by a second dose after 8 hours.
- On days 2 and 3, doses are taken morning and evening (12 hours apart).
- With food: Take with meals or a milky drink to improve absorption. If food cannot be tolerated, administer anyway, though exposure may be reduced.
- Vomiting: If vomiting occurs within 1 hour, repeat the dose.
- Missed dose: Take as soon as remembered, then continue the regimen until the full course is completed.
Side effects of Artemether and Lumefantrine Tablet
Possible Side effects of Artemether and Lumefantrine Tablet
- Headache
- Dizziness
- Sleep disturbances including insomnia
- Nausea and vomiting
- Abdominal pain and diarrhea
- Loss of appetite
- Fatigue, weakness, or muscle/joint pain
Storage instruction of Artemether and Lumefantrine Tablet
Store below 30°C. Protect from light.
Keep out of reach of children.
Packing details of Artemether and Lumefantrine Tablet
1 x 6 Alu/Alu blister pack
Artemether & Lumefantrine Tablets 80mg/480mg, Artefantrine-Forte is available in an Alu/Alu blister of 6 tablets. Such 01 blister in a unit carton with package insert.
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Trusted GMP Certified Artemether and Lumefantrine Tablet Manufacturer
At Conical Pharmaceuticals, we are Renown manufacture and export Artemether and Lumefantrine Tablets from our GMP certified facility in Ahmedabad, India. Classified under the antimalarial therapeutic class, this fixed‑dose combination is widely prescribed for the treatment of acute uncomplicated Plasmodium falciparum malaria, offering a reliable and effective solution for global health programs.
As a trusted bulk supplier and dependable partner for tender supplies, we also provide third‑party manufacturing services, enabling distributors, private label brands, and innovators to access flexible production and packaging solutions.
We are actively planning to exports into Central America (Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama), Central Africa (Cameroon, Chad, DRC, Equatorial Guinea, Gabon, Republic of the Congo), and CIS countries (Armenia, Azerbaijan, Belarus, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Uzbekistan), while strengthening distribution in Kenya, Nigeria, Ghana, Myanmar, Libya, Ethiopia, and the Philippines.
Importers benefit from complete regulatory documentation, including GMP Certificate, Free Sale Certificate, COPP, and tailored country‑specific dossiers to ensure smooth and compliant market entry.
With strong R&D capabilities, Conical Pharmaceuticals delivers consistent quality formulations, serving hospitals, tenders, distributors, and private label partners worldwide.
CUSTOM PACKAGING
Options available in size and style to meet your exact specifications and branding needs
SAMPLES AVAILABLE
Test before committing to bulk orders with complimentary samples for quality verification
LEAD TIME
45–60 days for timely delivery, ensuring reliable supply chain management
SHELF LIFE
Shelf Life: 24 months.
Frequently Asked Questions
Questions are useful tools, they open lines of communication; give us information; improve interactions, facilitate analysis, and many more.
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They are prescribed for the treatment of acute uncomplicated malaria (Plasmodium falciparum). This combination works by killing malaria parasites in the blood, helping relieve fever, chills, and other malaria symptoms.
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