Acetaminophen 500 mg Tablet
Acetaminophen (Paracetamol) 500‑mg-Tablet
Therapeutic Class: Pain Management
Dosage Forms: Tablets
Brand Name: Acetaminophen 500 mg Tablet™
How it works?
Uses of Acetaminophen 500 mg Tablet
How Acetaminophen 500 mg Tablet Works (Pharmacodynamics)
- Category: Analgesic (pain reliever) and antipyretic (fever reducer)
- Mechanism:
- Blocks an enzyme called cyclooxygenase (COX), which helps produce prostaglandins (chemicals that cause pain and fever)
- Works mainly in the brain, not in the rest of the body
- That’s why it reduces pain and fever but doesn’t help much with inflammation
Precautions of Acetaminophen 500 mg Tablet
Important Precautions While Taking Acetaminophen 500 mg Tablet
Avoid Taking Multiple Products
- Don’t take more than one medicine that contains acetaminophen at the same time.
Risk of Metabolic Acidosis (HAGMA)
- Rare cases of a serious condition called pyroglutamic acidosis have been reported.
- This can happen in people with:
- Kidney problems
- Sepsis (severe infection)
- Malnutrition
- Alcoholism
- Risk increases if acetaminophen is taken for a long time or with flucloxacillin.
- If suspected, stop acetaminophen and monitor closely.
Liver & Kidney Health
- People with liver or kidney disease should talk to a doctor before using acetaminophen.
- Taking too much can damage the liver—never exceed the recommended dose.
When to See a Doctor
- If headaches don’t go away
- If you have mild arthritis and need pain relief daily
- If symptoms persist or worsen
Glutathione Deficiency
- Use with caution if you have conditions that lower glutathione (a natural body chemical), such as:
- Metabolic disorders
- Malnutrition
- Chronic illness
- These conditions may increase the risk of acidosis.
Pregnancy & Breastfeeding
Pregnancy
- Studies show no major risks to the baby when acetaminophen is used during pregnancy.
- Some research on child development is inconclusive.
- If needed, use the lowest dose for the shortest time.
Breastfeeding
- Small amounts may pass into breast milk, but not enough to harm the baby.
- Safe to use while breastfeeding at normal doses.
Dosages administration of Acetaminophen 500 mg Tablet
Dosage Instructions of Acetaminophen 500 mg Tablet
Adults, Elderly & Children (16+ years)
- Dose: 1–2 tablets
- Frequency: Up to 4 times daily as needed
- Maximum: No more than 8 tablets in 24 hours
- Interval: At least 4 hours between doses
Children (10–15 years)
- Dose: 1 tablet
- Frequency: Up to 4 times daily
- Limit: Do not use for more than 3 days without medical advice.
- Interval: Minimum 4 hours between doses.
Not Suitable For
- Children under 10 years of age.
Directions for Use
- Route: Oral only.
- Form: Swallow tablets with water.
- Do not exceed the recommended dose or frequency.
Side effects of Acetaminophen 500 mg Tablet
Side Effects of Acetaminophen 500 mg Tablet
Frequency Classification
- Very common: ≥1 in 10
- Common: ≥1 in 100 to <1 in 10
- Uncommon: ≥1 in 1,000 to <1 in 100
- Rare: ≥1 in 10,000 to <1 in 1,000
- Very rare: <1 in 10,000
- Not known: Cannot be estimated from available data
Blood & Lymphatic Disorders
- Very rare:
- Agranulocytosis (low white blood cells)
- Thrombocytopenia (low platelets)
Immune System Disorders
- Very rare:
- Anaphylaxis (severe allergic reaction)
- Skin rashes, angioedema (swelling)
- Serious skin reactions (rare cases)
Metabolism & Nutrition Disorders
- Not known:
- High anion gap metabolic acidosis (HAGMA), especially in:
- Sepsis
- Renal impairment
- Malnutrition
- Chronic alcoholism
- Glutathione deficiency
- High anion gap metabolic acidosis (HAGMA), especially in:
Respiratory Disorders
- Very rare:
- Bronchospasm (more likely in asthmatics sensitive to aspirin/NSAIDs)
Hepatobiliary Disorders
- Very rare:
- Hepatic dysfunction (liver damage)
Selected Adverse Reactions Explained
Pyroglutamic Acidosis (HAGMA)
- May occur due to low glutathione levels
- Linked to prolonged use or combination with flucloxacillin
- Recommendation: Discontinue Acetaminophen and monitor closely if suspected
Bronchospasm
- Rare but possible
- Higher risk in patients with aspirin-sensitive asthma
Storage instruction of Acetaminophen 500 mg Tablet
Store in a cool, dry place at a temperature below 30°C and away from light.
Keep out of reach of children.
Packing details of Acetaminophen 500 mg Tablet
3×10 Alu/PVC Blister
Acetaminophen 500 mg Tablets is available in an Alu/PVC blister of 10 tablets. Such 03 blisters in a unit carton with a package insert.
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