Acetaminophen 500 mg Tablet

Therapeutic Class: Pain Management

Dosage Forms: Tablets

Brand Name: Acetaminophen 500 mg Tablet

Best Acetaminophen 500 mg Tablet manufacturer, supplier & exporter in India.

How it works?

Uses of Acetaminophen 500 mg Tablet

How Acetaminophen 500 mg Tablet Works (Pharmacodynamics)

  • Category: Analgesic (pain reliever) and antipyretic (fever reducer)
  • Mechanism:
    • Blocks an enzyme called cyclooxygenase (COX), which helps produce prostaglandins (chemicals that cause pain and fever)
    • Works mainly in the brain, not in the rest of the body
    • That’s why it reduces pain and fever but doesn’t help much with inflammation

Dosages administration of Acetaminophen 500 mg Tablet

Dosage Instructions of Acetaminophen 500 mg Tablet

Adults, Elderly & Children (16+ years)

  • Dose: 1–2 tablets
  • Frequency: Up to 4 times daily as needed
  • Maximum: No more than 8 tablets in 24 hours
  • Interval: At least 4 hours between doses

Children (10–15 years)

  • Dose: 1 tablet
  • Frequency: Up to 4 times daily
  • Limit: Do not use for more than 3 days without medical advice.
  • Interval: Minimum 4 hours between doses.

Not Suitable For

  • Children under 10 years of age.

Directions for Use

  • Route: Oral only.
  • Form: Swallow tablets with water.
  • Do not exceed the recommended dose or frequency.

Side effects of Acetaminophen 500 mg Tablet

Side Effects of Acetaminophen 500 mg Tablet

Frequency Classification

  • Very common: ≥1 in 10
  • Common: ≥1 in 100 to <1 in 10
  • Uncommon: ≥1 in 1,000 to <1 in 100
  • Rare: ≥1 in 10,000 to <1 in 1,000
  • Very rare: <1 in 10,000
  • Not known: Cannot be estimated from available data

Blood & Lymphatic Disorders

  • Very rare:
    • Agranulocytosis (low white blood cells)
    • Thrombocytopenia (low platelets)

Immune System Disorders

  • Very rare:
    • Anaphylaxis (severe allergic reaction)
    • Skin rashes, angioedema (swelling)
    • Serious skin reactions (rare cases)

Metabolism & Nutrition Disorders

  • Not known:
    • High anion gap metabolic acidosis (HAGMA), especially in:
      • Sepsis
      • Renal impairment
      • Malnutrition
      • Chronic alcoholism
      • Glutathione deficiency

Respiratory Disorders

  • Very rare:
    • Bronchospasm (more likely in asthmatics sensitive to aspirin/NSAIDs)

Hepatobiliary Disorders

  • Very rare:
    • Hepatic dysfunction (liver damage)

Selected Adverse Reactions Explained

Pyroglutamic Acidosis (HAGMA)

  • May occur due to low glutathione levels
  • Linked to prolonged use or combination with flucloxacillin
  • Recommendation: Discontinue Acetaminophen and monitor closely if suspected

Bronchospasm

  • Rare but possible
  • Higher risk in patients with aspirin-sensitive asthma

Precautions of Acetaminophen 500 mg Tablet

Important Precautions While Taking Acetaminophen 500 mg Tablet

Avoid Taking Multiple Products

  • Don’t take more than one medicine that contains acetaminophen at the same time.

Risk of Metabolic Acidosis (HAGMA)

  • Rare cases of a serious condition called pyroglutamic acidosis have been reported.
  • This can happen in people with:
    • Kidney problems
    • Sepsis (severe infection)
    • Malnutrition
    • Alcoholism
  • Risk increases if acetaminophen is taken for a long time or with flucloxacillin.
  • If suspected, stop acetaminophen and monitor closely.

Liver & Kidney Health

  • People with liver or kidney disease should talk to a doctor before using acetaminophen.
  • Taking too much can damage the liver—never exceed the recommended dose.

When to See a Doctor

  • If headaches don’t go away
  • If you have mild arthritis and need pain relief daily
  • If symptoms persist or worsen

Glutathione Deficiency

  • Use with caution if you have conditions that lower glutathione (a natural body chemical), such as:
    • Metabolic disorders
    • Malnutrition
    • Chronic illness
  • These conditions may increase the risk of acidosis.

Pregnancy &  Breastfeeding

Pregnancy

  • Studies show no major risks to the baby when acetaminophen is used during pregnancy.
  • Some research on child development is inconclusive.
  • If needed, use the lowest dose for the shortest time.

Breastfeeding

  • Small amounts may pass into breast milk, but not enough to harm the baby.
  • Safe to use while breastfeeding at normal doses.

Storage instruction of Acetaminophen 500 mg Tablet

Store in a cool, dry place at a temperature below 30°C and away from light.

Keep out of reach of children.

Packing details of Acetaminophen 500 mg Tablet

3×10 Alu/PVC Blister

Acetaminophen 500 mg Tablets is available in an Alu/PVC blister of 10 tablets. Such 03 blisters in a unit carton with a package insert.

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About Conical Pharmaceuticals

Conical Pharmaceuticals is a professionally managed and dynamic organization with decades of experience in the pharmaceutical field. With a desire of providing opportunities for a better life, we work very hard to bring quality drugs to our customers. We have instilled a level of trust and confidence amongst our clients by supplying the best quality products.

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