Cefepime For Injection 1000 mg
Cefepime For Injection USP 1000 mg
Therapeutic Class: Anti-Infectives
Dosage Forms: Injectables
Brand Name: Cefepime For Injection USP 1000 mg™
How it works?
Uses of Cefepime For Injection 1000 mg
What are the uses of Cefepime For Injection USP 1000 mg
- Pneumonia and other lung infections.
- Urinary tract infections (UTIs)
- Skin and soft tissue infections.
- Intra-abdominal infections.
- Severe infections in hospitals, like sepsis or infections caused by Pseudomonas aeruginosa.
- Febrile neutropenia (infections in patients with low white blood cell counts)
Precautions of Cefepime For Injection 1000 mg
- Serious allergic reactions can happen with cefepime, including rare but potentially life-threatening cases.
- Stop treatment immediately if any signs of allergy (like rash, swelling, or breathing issues) occur.
- Before starting treatment:
- Ask the patient if they’ve ever had a strong allergic reaction to cefepime, cephalosporins, penicillins, or any other beta-lactam antibiotics.
- Use extra caution with patients who’ve had mild allergic reactions to similar drugs.
- Asthma- or allergy-prone patients need close monitoring—especially with the first dose.
- In case of a serious reaction, emergency treatment like epinephrine and supportive care may be needed.
- Always be cautious when giving antibiotics to patients with any history of drug allergies.
Dosages administration of Cefepime For Injection 1000 mg
Dosages Of Cefepime For Injection 1000 mg
- Can be administered through a vein (IV) or into a muscle (IM)
- IV infusion is preferred for serious infections or life-threatening conditions
Treatment Duration
- Most infections: 7 to 10 days
- Severe cases or febrile neutropenia: minimum of 7 days, or until neutropenia resolves.
| Patient Group | Dosage Guidelines |
|---|---|
| Adults (normal kidney function) | Depends on severity; up to 2 g every 8 hours |
| Elderly (normal kidney function) | No dose adjustment needed |
| Adults with kidney issues | Same initial dose; reduce maintenance dose |
| Dialysis patients | Up to 68% removed in dialysis; use 48-hour gap between doses |
| Children ≤ 40 kg | 50 mg/kg every 12 hrs (mild), every 8 hrs (severe), max 10 days |
| Children 1–2 months old | Consider 30 mg/kg every 8–12 hrs; monitor carefully |
| Children > 40 kg | Use adult dosage |
| Children with kidney issues | Adjust dosage similar to renal-impaired adults |
| Liver impairment patients | No dose adjustment required |
Side effects of Cefepime For Injection 1000 mg
Common Side Effects of Cefepime For Injection 1000 mg
These are usually mild and temporary:
- Digestive issues: Diarrhea, nausea, vomiting
- Skin rash
- Vein reactions at the injection site, such as swelling or pain.
- Allergy-like symptoms: itching, redness.
- Low red or white blood cell count, which may cause fatigue or reduced immunity.
Less Common Side Effects
May occur in some patients:
- Yeast infections, like oral thrush or vaginal infection.
- Fever or chills.
- Headaches or dizziness.
- Digestive tract inflammation (colitis or pseudomembranous colitis)
- Increased levels in lab tests, such as liver enzymes or kidney markers.
- Changes in blood clotting times (usually detected by blood tests)
Rare but Serious Side Effects
These require medical attention if they occur:
- Severe allergic reactions (swelling, difficulty breathing, anaphylaxis)
- Confusion, hallucinations, or seizures.
- Kidney damage or failure, especially in people with existing kidney problems.
- Skin reactions like Stevens-Johnson Syndrome or toxic epidermal damage.
- Blood disorders, such as a sharp drop in white cells or platelets.
- Heart and circulation issues, such as abnormal bleeding or vessel swelling.
Children and Infants
- The side effect profile in children is similar to adults.
- Care is needed when dosing children with kidney issues.
Storage instruction of Cefepime For Injection 1000 mg
Store below 30°C temperature. Protect from light.
Keep the medicine out of reach of children.
Packing details of Cefepime For Injection 1000 mg
10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal.
Cefepime for Injection USP 1000 mg or Cefepime for Injection USP 1gm in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections USP in a unit carton with a pack insert.
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