Cefoperazone For Injection1000 mg
Cefoperazone For Injection 1000 mg
Therapeutic Class: Anti-Infectives
Dosage Forms: Injectables
Brand Name: Cefoperazone For Injection USP 1000 mg™
How it works?
Uses of Cefoperazone For Injection1000 mg
Cefoperazone For Injection USP 1000 mg is a powerful third-generation cephalosporin antibiotic used to treat moderate to severe bacterial infections across various body systems. It works by killing bacteria and reaches high concentrations in important tissues and fluids—including those often hard to treat.
Common uses include treatment of:
- Lung infections (e.g., pneumonia, bronchitis)
- Urinary tract infections (UTIs)
- Abdominal infections (e.g., peritonitis)
- Skin and soft tissue infections
- Gynecological infections
- Bone infections and joint infections
- Bloodstream infections (septicemia)
- Meningitis (when inflammation is present)
- Hospital-acquired infections
- Infections in surgical and reproductive organs
Precautions of Cefoperazone For Injection1000 mg
Allergic Reactions
- Serious allergies (like anaphylaxis) can happen—sometimes fatal.
- People with past allergies to antibiotics, especially penicillins or cephalosporins, should be treated with caution.
- If any allergic symptoms appear (rash, breathing difficulty, swelling), stop the medicine immediately and provide emergency care.
- Emergency treatments may include adrenaline (epinephrine), oxygen, IV steroids, and even intubation if needed.
Severe Skin Reactions
- In rare cases, patients may experience dangerous skin reactions like:
- Stevens-Johnson Syndrome (SJS)
- Toxic Epidermal Necrolysis (TEN)
- Skin peeling (dermatitis exfoliative)
- If this happens, the medicine must be stopped right away and treated properly.
Liver Problems
- The drug is mainly removed through bile, so if the liver is damaged or bile flow is blocked:
- The medicine may stay longer in the body.
- Dose adjustments may be needed.
- Patients with both liver and kidney issues need regular blood tests to track drug levels and avoid buildup.
Bleeding Risk
- Cefoperazone may cause vitamin K deficiency, leading to bleeding problems or coagulopathy.
- This can happen in:
- People with poor diets
- Digestive issues (like cystic fibrosis)
- Patients on long-term IV nutrition
- Monitor clotting time and give vitamin K if needed.
- If bleeding continues with no other cause, stop the medication.
Superinfections & Overgrowth
- Long-term use may allow other non-susceptible bacteria or fungi to grow.
- Keep monitoring for secondary infections and organ function—especially the liver, kidneys, and blood cells.
- This is especially important in premature infants and neonates.
Clostridium difficile-Associated Diarrhea (CDAD)
- Can range from mild diarrhea to severe, life-threatening colitis.
- Caused by imbalance in gut bacteria due to antibiotics.
- May happen during or even 2 months after treatment ends.
- Stop antibiotics if suspected and begin appropriate treatment.
- Avoid anti-diarrheal meds that slow down the gut during this.
Use in Infants and Newborns
- It has been used safely in infants, but caution is needed in premature babies.
- Weigh the benefits vs. risks before starting treatment.
- In neonates with jaundice, cefoperazone does NOT worsen bilirubin levels, which is a positive safety note.
Dosages administration of Cefoperazone For Injection1000 mg
For Adults
- Standard dose: 2 to 4 grams per day
- Given in two doses every 12 hours
In severe infections:
- Dose may increase up to 8 grams per day
- Higher doses of 12–16 grams/day have been used safely in some cases
For gonorrhea (uncomplicated):
- 500 mg single injection into the gluteus maximus or thigh muscle
Special Cases
Liver problems (hepatic dysfunction):
- Reduce dose if liver is severely affected or bile flow is blocked
- Max dose: 2 grams/day with close monitoring of drug levels
Kidney problems (renal dysfunction):
- Most people with kidney issues can use normal doses
- But if kidney function is very low (GFR < 18 ml/min or serum creatinine > 3.5 mg/dL), don’t exceed 4 grams/day
- If on dialysis, give the dose after the dialysis session
Combined liver and kidney issues:
- Dose must be adjusted carefully
- Do not exceed 2 grams/day without regular blood monitoring
For Infants and Children
- Dose: 50–200 mg/kg/day, split into 2–3 doses per day
- Maximum dose: 12 grams/day
For newborns (<8 days old):
- Give dose every 12 hours
How to Administer (IV and IM)
IV Infusion (Adults & Children):
- Dissolve 1 or 2 gram vial in 20–100 ml of sterile solution
- Infuse over 15 minutes to 1 hour
Continuous IV infusion:
- Dissolve 1 gram in 5 ml sterile water, mix with IV fluids
Direct IV injection (push):
- Max:
- Adults: 2 grams per dose
- Children: 50 mg/kg per dose
- Inject over 3–5 minutes with final concentration of 100 mg/ml
Intramuscular injection (IM):
- Deep into gluteus or thigh muscle (for gonorrhea, 500 mg single dose)
Before Surgery (Antibiotic Prophylaxis)
- Give 1–2 grams IV 30–90 minutes before surgery starts.
- Repeat every 12 hours (usually just for 24 hours)
- For higher-risk surgeries (e.g., open heart, colorectal), it may continue for up to 72 hours.
Side effects of Cefoperazone For Injection1000 mg
Common Side Effect While Taking Cefoperazone for Injection 1000 mg
Blood-Related Changes
- Lower counts of red and white blood cells
- Bleeding issues and poor blood clotting
- Positive Coombs test (a sign of immune reaction)
- High levels of a type of white blood cell (eosinophilia)
Allergic Reactions
- Severe reactions like anaphylactic shock
- Swelling, difficulty breathing, or skin reactions
- Rare heart-related allergic response (Kounis syndrome)
Blood Vessel Issues
- Bleeding
- Vein inflammation at the injection site (phlebitis)
Digestive Problems
- Diarrhea and vomiting
- Serious bowel inflammation (pseudomembranous colitis)
Liver Function
- Elevated liver enzymes (seen in tests)
- Yellowing of skin or eyes (jaundice)
Skin Reactions
- Rash, itching, and hives
- Severe skin conditions like Stevens-Johnson Syndrome, toxic epidermal necrolysis, or peeling skin
General Discomfort
- Pain at the injection site
- Fever
Storage instruction of Cefoperazone For Injection1000 mg
Store below 30°C temperature. Protect from light.
Keep the medicine out of reach of children.
Packing details of Cefoperazone For Injection1000 mg
10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal.
Cefoperazone for Injection 1000 mg in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections USP in a unit carton with a pack insert.
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