Ceftriaxone & Sulbactam Injection 1500mg
Ceftriaxone & Sulbactam Injection 1500 mg.
Therapeutic Class: Anti-Infectives
Dosage Forms: Injectables
Brand Name: Ceftriaxone & Sulbactam Injection 1500 mg™
How it works?
Uses of Ceftriaxone & Sulbactam Injection 1500mg
Ceftriaxone and Sulbactam Injection Uses.
– Serious Blood Infections.
– Sepsis (a life-threatening body-wide infection)
– Brain & Nervous System.
– Meningitis (inflammation of the membranes around the brain and spinal cord)
– Lungs & Respiratory Tract.
– Pneumonia.
– Other respiratory infections, including ear, nose, and throat infections.
– Urinary and Reproductive Systems.
– Kidney and urinary tract infections.
– Genital infections, including gonorrhea.
– Bones, Joints & Skin.
– Infections of the bones, joints, soft tissue, wounds, and skin.
– Digestive Tract.
– Abdominal infections, including.
– Peritonitis.
– Infections in the biliary (bile ducts) and gastrointestinal tract.
– Immunocompromised Patients.
– Treatment of infections in individuals with weakened immune systems.
– Surgical Protection.
– Used before surgery for perioperative infection prevention.
How does the ceftriaxone & sulbactam injection of 1500 mg work?
Ceftriaxone & Sulbactam injection is a combination antibiotic injection used to treat a wide range of bacterial infections. Here’s how it works
Stops Bacteria from Constructing Their Cell Walls → Ceftriaxone acts on the building of the bacterial cell wall, weakening bacteria and causing them to burst.
Protects Ceftriaxone from Being Degraded → Sulbactam guards ceftriaxone against certain chemicals (such as beta-lactamase enzymes) that bacteria employ to become resistant to antibiotics.
Ceftriaxone & Sulbactam Injection is used to treat a variety of bacterial infections. It is especially helpful in managing moderate to severe infections
Precautions of Ceftriaxone & Sulbactam Injection 1500mg
Cautions and Warnings for Ceftriaxone & Sulbactam 1500 mg Injection
Allergy Alert:
- This medicine should be used carefully in people allergic to penicillin.
- In rare cases, severe allergic reactions may occur, requiring emergency treatment like epinephrine (adrenaline) and urgent medical care.
Risk of Serious Diarrhea:
- A type of diarrhea caused by Clostridium difficile has been reported with many antibiotics, including this one.
- It can range from mild to life-threatening, so any diarrhea after starting this medication should be evaluated by a doctor immediately.
Anemia Risk:
- A specific type of immune-related anemia has been seen in patients on cephalosporin antibiotics like ceftriaxone.
- If anemia develops while taking this medicine, the treatment should be stopped until the exact cause is identified.
Kidney Function Monitoring:
- Some temporary changes in kidney markers (BUN and serum creatinine) have been observed.
- However, the risk of kidney damage with this medicine is similar to other drugs in the same class when taken at the recommended dose.
Blood Clotting Changes:
- Rare changes in blood clotting time (prothrombin time) may occur.
- Patients with liver problems or poor nutrition (which may cause low vitamin K levels) might need extra monitoring during treatment.
Gallbladder Effects:
- Some patients have shown gallbladder changes on ultrasound while taking this medicine.
- In some cases, they also had symptoms related to gallbladder disease.
Use With Caution If:
- The patient has a history of digestive issues, especially conditions like colitis (inflammation of the colon).
Dosages administration of Ceftriaxone & Sulbactam Injection 1500mg
Safe Dosing of Ceftriaxone & Sulbactam Injection in Adults, Infants, and Neonates.
Adult Dosage (Ceftriaxone & Sulbactam injection)
- The usual dose ranges from 1.5 grams to 3 grams, given every 6 hours.
- This includes:
- 1 to 2 grams of Ceftriaxone (as sodium salt)
- 0.5 to 1 gram of Sulbactam (as sodium salt)
- Important Limit: Do not exceed 4 grams of Sulbactam per day.
Dosage for Neonates, Infants, and Children (up to 12 years old)
- For neonates (0–14 days old):
- Dose: 20 to 50 mg/kg of body weight, once per day.
- Max: Do not go over 50 mg/kg/day.
- No need to differentiate between premature or full-term newborns.
- For Infants and Children (15 days to 12 years):
- Dose: 20 to 80 mg/kg, once per day.
- If the child weighs 50 kg or more, use adult dosing.
- If giving more than 50 mg/kg intravenously, administer it as an infusion over at least 30 minutes.
Side effects of Ceftriaxone & Sulbactam Injection 1500mg
Ceftriaxone & Sulbactam Injection 1500 mg Side Effects:
How often side effects happen:
– Very common: Happens in 1 out of 10 people or more.
– Common: Between 1 in 100 and 1 in 10 people.
– Uncommon: Between 1 in 1,000 and 1 in 100 people.
– Rare: Between 1 in 10,000 and 1 in 1,000 people.
– Not known: Not enough data to estimate.
Blood-related Effects of Ceftriaxone & Sulbactam Injection
– Common: Increases in certain white blood cells (eosinophilia), low white cells (leukopenia), and low platelets (thrombocytopenia)
– Uncommon: Anemia, issues with clotting.
– Not known: Severe drop in red blood cells (haemolytic anemia), dangerously low white cell count (agranulocytosis)
Immune System
– Not known: Severe allergic responses (like anaphylactic shock), general allergic reactions, and rare reactions such as Jarisch-Herxheimer.
Nervous System
– Uncommon: Headache, dizziness.
– Rare: Brain dysfunction (encephalopathy)
– Not known: Seizures.
Ear and Balance
– Not known: Sensation of spinning or dizziness (vertigo)
Lungs & Breathing
– Rare: Wheezing or shortness of breath (bronchospasm)
Digestive System
– Common: diarrhea, loose stools.
– Uncommon: Nausea, vomiting.
– Not known: Inflammation of the pancreas, mouth sores, and tongue inflammation.
Liver & Gallbladder
– Common: Elevated liver enzymes in blood tests.
– Not known: Gallstones, jaundice in newborns (kernicterus)
Skin & Allergies
– Common: Skin rash.
– Uncommon: Itching.
– Rare: Hives
– Not known: Serious skin reactions like Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, DRESS, and others.
Kidneys & Urinary
– Rare: Blood or sugar in urine.
– Not known: reduced urine output, temporary kidney deposits.
Injection Site & General Reactions
– Uncommon: Vein inflammation, pain at injection site, fever.
– Rare: Swelling, chills.
Lab Tests May Be Affected
– Uncommon: Increased creatinine (kidney function marker)
– Not known: False positives in:
– Coombs test.
– Galactosemia test.
– Some sugar (glucose) tests.
Storage instruction of Ceftriaxone & Sulbactam Injection 1500mg
Store below 30°C. Protect from light and moisture. Keep the medicine out of reach of children.
Packing details of Ceftriaxone & Sulbactam Injection 1500mg
10 ml clear USP type III glass vial with a grey bromobutyl rubber stopper, sealed with a red BP flip-off aluminum seal.
Ceftriaxone 1000 mg & Sulbactam 500 mg (Ceftriaxone & Sulbactam Injection) dry powder for injection in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections BP in a unit carton with a pack insert.
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