Ceftriaxone & Sulbactam Injection 1500mg
Ceftriaxone & Sulbactam Injection 1500 mg.
Therapeutic Class: Anti-Infectives
Dosage Forms: Injectables
Brand Name: Ceftriaxone & Sulbactam Injection 1500 mg™
How it works?
Uses of Ceftriaxone & Sulbactam Injection 1500mg
Ceftriaxone and Sulbactam Injection Uses.
– Serious Blood Infections.
– Sepsis (a life-threatening body-wide infection)
– Brain & Nervous System.
– Meningitis (inflammation of the membranes around the brain and spinal cord)
– Lungs & Respiratory Tract.
– Pneumonia.
– Other respiratory infections, including ear, nose, and throat infections.
– Urinary and Reproductive Systems.
– Kidney and urinary tract infections.
– Genital infections, including gonorrhea.
– Bones, Joints & Skin.
– Infections of the bones, joints, soft tissue, wounds, and skin.
– Digestive Tract.
– Abdominal infections, including.
– Peritonitis.
– Infections in the biliary (bile ducts) and gastrointestinal tract.
– Immunocompromised Patients.
– Treatment of infections in individuals with weakened immune systems.
– Surgical Protection.
– Used before surgery for perioperative infection prevention.
How does the ceftriaxone & sulbactam injection of 1500 mg work?
Ceftriaxone & Sulbactam injection is a combination antibiotic injection used to treat a wide range of bacterial infections. Here’s how it works
Stops Bacteria from Constructing Their Cell Walls → Ceftriaxone acts on the building of the bacterial cell wall, weakening bacteria and causing them to burst.
Protects Ceftriaxone from Being Degraded → Sulbactam guards ceftriaxone against certain chemicals (such as beta-lactamase enzymes) that bacteria employ to become resistant to antibiotics.
Ceftriaxone & Sulbactam Injection is used to treat a variety of bacterial infections. It is especially helpful in managing moderate to severe infections
Precautions of Ceftriaxone & Sulbactam Injection 1500mg
Cautions and Warnings for Ceftriaxone & Sulbactam 1500 mg Injection
Allergy Alert:
- This medicine should be used carefully in people allergic to penicillin.
- In rare cases, severe allergic reactions may occur, requiring emergency treatment like epinephrine (adrenaline) and urgent medical care.
Risk of Serious Diarrhea:
- A type of diarrhea caused by Clostridium difficile has been reported with many antibiotics, including this one.
- It can range from mild to life-threatening, so any diarrhea after starting this medication should be evaluated by a doctor immediately.
Anemia Risk:
- A specific type of immune-related anemia has been seen in patients on cephalosporin antibiotics like ceftriaxone.
- If anemia develops while taking this medicine, the treatment should be stopped until the exact cause is identified.
Kidney Function Monitoring:
- Some temporary changes in kidney markers (BUN and serum creatinine) have been observed.
- However, the risk of kidney damage with this medicine is similar to other drugs in the same class when taken at the recommended dose.
Blood Clotting Changes:
- Rare changes in blood clotting time (prothrombin time) may occur.
- Patients with liver problems or poor nutrition (which may cause low vitamin K levels) might need extra monitoring during treatment.
Gallbladder Effects:
- Some patients have shown gallbladder changes on ultrasound while taking this medicine.
- In some cases, they also had symptoms related to gallbladder disease.
Use With Caution If:
- The patient has a history of digestive issues, especially conditions like colitis (inflammation of the colon).
Dosages administration of Ceftriaxone & Sulbactam Injection 1500mg
Safe Dosing of Ceftriaxone & Sulbactam Injection in Adults, Infants, and Neonates.
Adult Dosage (Ceftriaxone & Sulbactam injection)
- The usual dose ranges from 1.5 grams to 3 grams, given every 6 hours.
- This includes:
- 1 to 2 grams of Ceftriaxone (as sodium salt)
- 0.5 to 1 gram of Sulbactam (as sodium salt)
- Important Limit: Do not exceed 4 grams of Sulbactam per day.
Dosage for Neonates, Infants, and Children (up to 12 years old)
- For neonates (0–14 days old):
- Dose: 20 to 50 mg/kg of body weight, once per day.
- Max: Do not go over 50 mg/kg/day.
- No need to differentiate between premature or full-term newborns.
- For Infants and Children (15 days to 12 years):
- Dose: 20 to 80 mg/kg, once per day.
- If the child weighs 50 kg or more, use adult dosing.
- If giving more than 50 mg/kg intravenously, administer it as an infusion over at least 30 minutes.
Side effects of Ceftriaxone & Sulbactam Injection 1500mg
Ceftriaxone & Sulbactam Injection 1500 mg Side Effects:
How often side effects happen:
– Very common: Happens in 1 out of 10 people or more.
– Common: Between 1 in 100 and 1 in 10 people.
– Uncommon: Between 1 in 1,000 and 1 in 100 people.
– Rare: Between 1 in 10,000 and 1 in 1,000 people.
– Not known: Not enough data to estimate.
Blood-related Effects of Ceftriaxone & Sulbactam Injection
– Common: Increases in certain white blood cells (eosinophilia), low white cells (leukopenia), and low platelets (thrombocytopenia)
– Uncommon: Anemia, issues with clotting.
– Not known: Severe drop in red blood cells (haemolytic anemia), dangerously low white cell count (agranulocytosis)
Immune System
– Not known: Severe allergic responses (like anaphylactic shock), general allergic reactions, and rare reactions such as Jarisch-Herxheimer.
Nervous System
– Uncommon: Headache, dizziness.
– Rare: Brain dysfunction (encephalopathy)
– Not known: Seizures.
Ear and Balance
– Not known: Sensation of spinning or dizziness (vertigo)
Lungs & Breathing
– Rare: Wheezing or shortness of breath (bronchospasm)
Digestive System
– Common: diarrhea, loose stools.
– Uncommon: Nausea, vomiting.
– Not known: Inflammation of the pancreas, mouth sores, and tongue inflammation.
Liver & Gallbladder
– Common: Elevated liver enzymes in blood tests.
– Not known: Gallstones, jaundice in newborns (kernicterus)
Skin & Allergies
– Common: Skin rash.
– Uncommon: Itching.
– Rare: Hives
– Not known: Serious skin reactions like Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, DRESS, and others.
Kidneys & Urinary
– Rare: Blood or sugar in urine.
– Not known: reduced urine output, temporary kidney deposits.
Injection Site & General Reactions
– Uncommon: Vein inflammation, pain at injection site, fever.
– Rare: Swelling, chills.
Lab Tests May Be Affected
– Uncommon: Increased creatinine (kidney function marker)
– Not known: False positives in:
– Coombs test.
– Galactosemia test.
– Some sugar (glucose) tests.
Storage instruction of Ceftriaxone & Sulbactam Injection 1500mg
Store below 30°C. Protect from light and moisture. Keep the medicine out of reach of children.
Packing details of Ceftriaxone & Sulbactam Injection 1500mg
10 ml clear USP type III glass vial with a grey bromobutyl rubber stopper, sealed with a red BP flip-off aluminum seal.
Ceftriaxone 1000 mg & Sulbactam 500 mg (Ceftriaxone & Sulbactam Injection) dry powder for injection in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections BP in a unit carton with a pack insert.
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SAMPLES AVAILABLE
Test before committing to bulk orders with complimentary samples for quality verification
LEAD TIME
45–60 days for timely delivery, ensuring reliable supply chain management
SHELF LIFE
18 months when stored below 30°C, ensuring maximum stability and viability
Quality & Regulatory Certifications
WHO-GMP Certified Facility • FDA Approved (Jordan) • Full Regulatory Dossier Support • Certificate of Analysis • Free Sale Certificate • COPP Documentation
Frequently Asked Questions
Questions are useful tools, they open lines of communication; give us information; improve interactions, facilitate analysis, and many more.
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It is a high‑demand hospital antibiotic, widely prescribed for resistant infections, ensuring consistent turnover.
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