Ceftriaxone & Tazobactam Injection 1125 mg
Ceftriaxone & Tazobactam Injection 1125 mg
Therapeutic Class: Anti-Infectives
Dosage Forms: Injectables
Brand Name: Ceftriaxone & Tazobactam Injection 1125 mg™
How it works?
Uses of Ceftriaxone & Tazobactam Injection 1125 mg
What Is Ceftriaxone & Tazobactam Injection 1125 mg Used For?
Ceftriaxone & Tazobactam Injection 1125 mg is a powerful combination antibiotic used to treat a wide range of bacterial infections, especially when resistance to other antibiotics is a concern.
How Does Ceftriaxone & Tazobactam Injection 1125 mg Work?
- Ceftriaxone: Kills bacteria by stopping them from building their protective cell wall.
- Tazobactam: Blocks enzymes (beta-lactamases) that some bacteria use to resist antibiotics, making ceftriaxone more effective.
Together, they offer strong protection against resistant bacteria and are especially useful in hospital settings.
Common Uses of Ceftriaxone & Tazobactam Injection 1125 mg
Respiratory Tract Infections
- Pneumonia (including hospital-acquired)
- Bronchitis
- Lung infections in ventilated patients
Urinary Tract Infections (UTIs)
- Complicated UTIs
- Kidney infections (pyelonephritis)
Skin and Soft Tissue Infections
- Cellulitis
- Abscesses
- Diabetic foot infections
- Post-surgical wound infections
Bone and Joint Infections
- Osteomyelitis
- Septic arthritis
Brain and Nervous System
- Meningitis
- Brain abscess
Bloodstream Infections
- Sepsis
- Bacteremia
Abdominal and Pelvic Infections
- Appendicitis
- Peritonitis
- Pelvic inflammatory disease
- Postpartum infections
Ear Infections
- Acute bacterial otitis media (especially in children)
Surgical Prophylaxis
- Given before surgery to prevent infections
Typhoid Fever
- Used when oral antibiotics are not suitable.
Pediatric Use
- Safe for children (except newborns with high bilirubin levels)
- Used for serious infections and ear infections.
Precautions of Ceftriaxone & Tazobactam Injection 1125 mg
Precautions While Taking Ceftriaxone & Tazobactam Injection 1125 mg
Allergy Warning
- If you’re allergic to penicillin or cephalosporins, tell your doctor before starting.
- Serious allergic reactions (like swelling, rash, or breathing trouble) may need emergency treatment.
- Stop the medicine and get help immediately if you notice any signs of a severe reaction.
Diarrhea Risk
- This medicine can cause Clostridium difficile-related diarrhea, which may be mild or life-threatening.
- If you get severe or long-lasting diarrhea, even after stopping the medicine, contact your doctor right away.
Blood-Related Issues
- Rarely, this medicine may cause immune-related anemia (your body attacks its own red blood cells).
- If you feel unusually tired or dizzy or notice pale skin, tell your doctor. They may stop the medicine and run tests.
Kidney Health
- Most patients with kidney problems don’t need a dose change, but your doctor may monitor your blood levels.
- If the drug builds up in your body, the dose may be reduced.
- No safety data is available for children with kidney problems, so doctors will decide carefully.
Liver Health
- Usually, no dose change is needed for liver problems.
- But if you have both liver and kidney issues, your dose should not exceed 2 grams per day unless your doctor is monitoring you closely.
- No safety data is available for children with liver problems, so use with caution.
Blood Clotting (Prothrombin Time)
- This medicine may affect blood clotting in people with:
- Liver disease
- Poor nutrition
- Low vitamin K levels
- Your doctor may check your prothrombin time and give vitamin K if needed.
Gallbladder and Pancreas
- Some patients may develop gallbladder issues or pancreatitis (inflammation of the pancreas).
- These problems usually go away after stopping the medicine.
- Let your doctor know if you feel abdominal pain, nausea, or vomiting.
Children
- Use with caution in children with high bilirubin levels (especially newborns).
- Not enough data is available for children with kidney or liver problems, so doctors will decide carefully.
Dosages administration of Ceftriaxone & Tazobactam Injection 1125 mg
- Dosage Guidelines of Ceftriaxone & Tazobactam Injection 1125 mg
Adults
Usual dose: 1125 mg (1000 mg Ceftriaxone + 125 mg Tazobactam)
How often: Once a day or split into two doses (every 12 hours)
Maximum daily dose: Should not exceed 4 grams of ceftriaxone.
Before Surgery (Surgical Prophylaxis)
Dose: 1 gram IV
Timing: 30 minutes to 2 hours before surgery.
Duration of Treatment
Continue for at least 2 days after symptoms disappear.
Typical course: 4 to 14 days.
Complicated infections may need longer treatment.
Streptococcal infections: Treat for at least 10 days.
Pediatric Patients
Serious infections: 50–75 mg/kg/day (based on ceftriaxone), divided every 12 hours.
Maximum daily dose: Should not exceed 2 grams of ceftriaxone.
Ear infections (acute otitis media): One-time IM dose of 50 mg/kg (max 1 gram)
Directions for Use - Intravenous (IV) Injection.
- Inject slowly over 2–4 minutes.
- Intravenous (IV) Infusion for over 30 minutes.
- Intramuscular (IM) Injection.
Use a deep IM injection.
If the dose is more than 1 gram, split it and inject it into two different sites.
How to Prepare the Injection.
Mix with one of the following:
Sterile Water for Injection.
Normal Saline
Dextrose Solution (5% or 10%)
Use the solution immediately after mixing to ensure safety and effectiveness.
Side effects of Ceftriaxone & Tazobactam Injection 1125 mg
Side Effects of Ceftriaxone & Tazobactam Injection 1125 mg
- Local Reactions
- Common (≈1%): Injection area pain, induration (hardening), soreness
- Seldom (<1%): Phlebitis (vein inflammation) after IV injection
- Extremely Seldom (<0.1%): Severe skin reactions such as:
- Multiform erythema
- Stevens‑Johnson syndrome
- Lyell’s syndrome (toxic epidermal necrolysis)
- Hypersensitivity Reactions
- Common (1.7%): Rash
- Seldom (<1%): Edema, urticaria, fever, chills, pruritus, allergic dermatitis
- Extremely Seldom (<0.1%): Severe skin reactions (see above)
Hematologic Effects
Common:
- Eosinophilia (6%)
- Thrombocytosis (5.1%)
- Leukopenia (2.1%)
- Seldom (<1%):
- Hemolytic anemia, anemia
- Lymphopenia, neutropenia
- Thrombocytopenia
- Extended prothrombin time
Gastrointestinal Effects
Common (2.7%): Diarrhea
Rare (<1%): Stomatitis, glossitis, dysgeusia (changed taste), nausea, vomiting
Hepatic Effects
Common:
- Elevated SGOT (3.1%)
- Elevated SGPT (3.3%)
- Seldom (<1%): Increased bilirubin, alkaline phosphatase
Renal Effects
- Common (1.2%): Increased BUN
Rare (<1%): Nephrolithiasis, oliguria, urine casts, elevated creatinine
Central Nervous System
- Seldom (<1%): Seizures, headaches, lightheadedness
Genitourinary Effects
- Rare (<1%): Vaginitis, moniliasis (yeast infection)
Miscellaneous
- Rare (<1%): Flushing, diaphoresis
Extremely Rare (<0.1%):
- Flatulence, dyspepsia, colitis, abdominal pain
Palpitations with epistaxis (nosebleed)
- Allergic pneumonitis with serum sickness
- Gallbladder sludge, stones, hepatitis
- Hematuria with glycosuria
- Monocytosis, leukocytosis, lymphocytosis
- Decreased prothrombin duration
- Precipitations in kidneys
Notes
Most adverse effects are minor and self‑resolving.
Close monitoring is required for severe hypersensitivity reactions, hematologic issues, and renal or liver dysfunction.
Local reactions can depend on injection technique and formulation factors (e.g., osmolality, pH).
Storage instruction of Ceftriaxone & Tazobactam Injection 1125 mg
Store below 30°C temperature. Protect from light.
Keep the medicine out of reach of children.
Packing details of Ceftriaxone & Tazobactam Injection 1125 mg
10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal.
Ceftriaxone & Tazobactam Injection 1125 mg in a glass vial is supplied with a 10 ml plastic ampoule of diluent (Sterilized Water for Injections) in a unit carton with a pack insert.
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GMP Certified Ceftriaxone & Tazobactam Injection 1125 mg Manufacturer
At Conical Pharmaceuticals, we proudly manufacture Ceftriaxone & Tazobactam Injection 1125 mg at our GMP‑certified facility in Ahmedabad, India. This advanced antibiotic combines Ceftriaxone, a third‑generation cephalosporin, with Tazobactam, a β‑lactamase inhibitor that enhances its effectiveness against resistant bacteria.
The formulation is widely recognized for its broad‑spectrum coverage, treating respiratory, urinary tract, abdominal, skin, bone, and joint infections. It is especially valuable in hospitals for managing pneumonia, septicemia, meningitis, and intra‑abdominal infections. By preventing bacterial resistance, Tazobactam ensures higher treatment success, while the combination is also used for surgical prophylaxis and delivers rapid clinical improvement, often within three to five days.
Pharmaceutical distributors and importers actively seek Ceftriaxone & Tazobactam Injection 1125 mg because of its proven efficacy and essential role in hospital procurement. Conical Pharmaceuticals Supply bulk demand for Large scale pharmaceutical distributors , International Importers , hospitals, tenders, and distributors worldwide, while offering flexible third‑party contract manufacturing and private labeling services.
Importers benefit from complete regulatory documentation, including GMP Certificate, Free Sale Certificate, COPP, and tailored dossiers, with MOQ customized to buyer requirements.
We are planning to exports Ceftriaxone & Tazobactam Injection 1125 mg across Central America, Central Africa, and CIS countries, while strengthening distribution in Nepal, Nigeria, Somalia, Ethiopia, Afghanistan, Myanmar, Kenya, Sudan, Ghana, Bangladesh, Tanzania, Uganda, Sri Lanka, Iraq, and Kuwait.
CUSTOM PACKAGING
Options available in size and style to meet your exact specifications and branding needs
SAMPLES AVAILABLE
Test before committing to bulk orders with complimentary samples for quality verification
LEAD TIME
45–60 days for timely delivery, ensuring reliable supply chain management
SHELF LIFE
Shelf Life: 24 months.
Frequently Asked Questions
Questions are useful tools, they open lines of communication; give us information; improve interactions, facilitate analysis, and many more.
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It is a combination of Ceftriaxone, a third‑generation cephalosporin antibiotic, and Tazobactam, a β‑lactamase inhibitor, designed to treat resistant bacterial infections.
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