What Are The Uses of Cefuroxime Injection 1500 mg?
Cefuroxime is a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It works by stopping bacteria from building their cell walls, which leads to their death.
Common Infections Treated
Respiratory Tract Infections
Urinary Tract Infections (UTIs)
Skin and Soft Tissue Infections
Bone and Joint Infections
Central Nervous System
Bloodstream Infections
Ear, Nose, and Throat Infections
Sexually Transmitted Infections
Lyme Disease
Surgical Prophylaxis
Pediatric Use
Dosage
Table 1: Adults and children ≥ 40 kg
| Indication | Dosage |
| Community-acquired pneumonia and acute exacerbations of chronic bronchitis | 750 mg every 8 hours (intravenously or intramuscularly) |
| Soft-tissue infections: cellulitis, erysipelas
and wound infections. |
750 mg every 8 hours (intravenously or intramuscularly) |
| Intra-abdominal infections | 1.5 g every 8 hours (intravenously or intramuscularly) |
| Complicated urinary tract infections, including pyelonephritis | 1.5 g every 8 hours (intravenously or intramuscularly) |
| Severe infections | 750 mg every 6 hours (intravenously)
1.5 g every 8 hours (intravenously) |
| Surgical prophylaxis for gastrointestinal,
gynaecological surgery (including caesarean section) and orthopaedic operations |
1.5 g with the induction of anaesthesia. This
may be supplemented with two 750 mg doses (intramuscularly) after 8 hours and 16 hours. |
| Surgical prophylaxis for cardiovascular and oesophageal operations | 1.5 g with induction of anaesthesia followed by 750 mg (intramuscularly) every 8 hours for a further 24 hours. |
Table 2: Children < 40 kg
| Infants and toddlers > 3 weeks and children < 40 kg | Infants (birth to 3 weeks) | |
| Community-acquired pneumonia | 30 to 100 mg/kg/day
(intravenously) given as 3 or 4 divided doses; a dose of 60 mg/kg/day is appropriate for most infections. |
30 to 100 mg/kg/day (intravenously) given as 2 or 3 divided doses |
| Complicated urinary tract infections, including pyelonephritis | ||
| Soft-tissue infections: cellulitis, erysipelas, and wound infections. | ||
| Intra-abdominal infections |
Renal impairment
Cefuroxime is primarily excreted by the kidneys. Therefore, as with all such antibiotics, in patients with markedly impaired renal function, it is recommended that the dosage of cefuroxime should be reduced to compensate for its slower excretion.
Table 3: Recommended doses for cefuroxime in renal impairment
| Creatinine clearance | T1/2 (hrs) | Dose mg |
| > 20 mL/min/1.73 m2 | 1.7-2.6 | It is not necessary to reduce the standard dose (750 mg to 1.5 g three times daily). |
| 10-20 mL/min/1.73 m2 | 4.3-6.5 | 750 mg twice daily |
| < 10 mL/min/1.73 m2 | 14.8-22.3 | 750 mg once daily |
| Patients on haemodialysis | 3.75 | A further 750 mg dose should be given intravenously or intramuscularly at the end of each dialysis; in addition to parenteral use, cefuroxime sodium can be incorporated into the peritoneal dialysis fluid (usually 250 mg for every 2 litres of dialysis fluid). |
| Patients in renal failure on continuous arteriovenous haemodialysis (CAVH) or high-flux haemofiltration (HF) in intensive therapy units | 7.9-12.6 (CAVH)
1.6 (HF) |
750 mg twice daily; for low flux hemofiltration, follow the dosage recommended under impaired renal function. |
Hepatic impairment
Cefuroxime is primarily eliminated by the kidney. In patients with hepatic dysfunction, this is not expected to affect the pharmacokinetics of cefuroxime.
Most Typical:
– Neutropenia
– Eosinophilia
brief increase in bilirubin or enzymes in the liver
Pain and thrombophlebitis are examples of injection site responses.
Notably:
– Although there is no proof of liver damage, these symptoms are more common in those who already have liver disease.
– The frequency differs depending on the patient group and indication.
– Although uncommon, severe responses can occur, particularly in cases of renal impairment.
| Frequency | Definition |
| Very Common | ≥ 1/10 |
| Common | ≥ 1/100 to < 1/10 |
| Uncommon | ≥ 1/1000 to < 1/100 |
| Rare | ≥ 1/10,000 to < 1/1000 |
| Very Rare | < 1/10,000 |
| Not Known | Cannot be estimated |
Infections (Unknown Frequency)
Blood & Lymphatic System
| Frequency | Adverse Effects |
|---|---|
| Common | Neutropenia, Eosinophilia, Reduced hemoglobin |
| Uncommon | Leukopenia, Positive Coombs test |
| Unknown | Thrombocytopenia, Hemolytic anemia |
Immune System (Unknown Frequency)
Cardiac System (Unknown Frequency)
Gastrointestinal System.
| Frequency | Adverse Effects |
|---|---|
| Uncommon | Diarrhea, Nausea |
| Unknown | Pseudomembranous colitis |
Hepatobiliary System
| Frequency | Adverse Effects |
|---|---|
| Common | Temporary rise in liver enzymes (ALT, AST) |
| Uncommon | Brief increase in bilirubin |
| Post-marketing | Jaundice, Cholestasis, Hepatitis |
Skin & Subcutaneous Tissue
| Frequency | Adverse Effects |
|---|---|
| Uncommon | Rash, Urticaria, Pruritus |
| Unknown | Stevens-Johnson syndrome, Toxic epidermal necrolysis, Erythema multiforme, Angioedema, DRESS syndrome |
General Disorders & Injection Site
| Frequency | Adverse Effects |
|---|---|
| Common | Injection site pain, Thrombophlebitis |
| Note | Pain is dose-dependent but rarely causes discontinuation |
Neurological Effects (Infrequent but Severe)
Pediatric Safety
Precautions While Taking Cefuroxime Injection 1500 mg
Hypersensitivity Reactions
Severe Skin Reactions (SCARs)
Kidney Safety
Overgrowth of Other Germs
Intra-abdominal Infections
Interference with Lab Tests
Eye Safety
Sodium Content
Store below 30°C temperature. Protect from light.
Keep the medicine out of reach of children.
10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal.
Cefuroxime Injection 1500 mg in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections USP in a unit carton with a pack insert.
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