Cefuroxime Axetil Tablet
Cefuroxime 500 mg Tablet.
Therapeutic Class: Anti-Infectives
Dosage Forms: Tablets
Brand Name: CVPROX-500 Tablet™
How it works?
Uses of Cefuroxime Axetil Tablet
- When you take a cefuroxime axetil tablet, your body uses enzymes called esterases to convert it into its active form, cefuroxime.
- Cefuroxime then attaches to special proteins in bacteria called penicillin-binding proteins (PBPs).
- These PBPs help bacteria build their cell walls, which are essential for their survival.
- By blocking PBPs, cefuroxime stops bacteria from making strong cell walls.
- Without proper cell walls, the bacteria break apart and die.
Precautions of Cefuroxime Axetil Tablet
Allergy (Hypersensitivity) Risks while taking Cefuroxime Axetil Tablet.
- If someone is allergic to penicillins or other beta-lactam antibiotics, they might also react to cefuroxime.
- In rare cases, these allergic reactions can be severe or even life-threatening.
- If a serious reaction occurs, stop the medicine immediately and seek emergency help.
- Before starting treatment, doctors should check if the patient has a history of allergy to cefuroxime or similar antibiotics.
Jarisch-Herxheimer Reaction
- This reaction may happen when treating Lyme disease with cefuroxime.
- It’s caused by the medicine killing the Lyme disease bacteria (Borrelia burgdorferi).
- Symptoms may include fever, chills, or muscle pain—but they are usually short-lived and harmless.
- Patients should be informed that this is a normal response during treatment.
Overgrowth of Unwanted Germs
- Like other antibiotics, cefuroxime may allow Candida or other bacteria (enterococci, Clostridium difficile) to grow too much.
- This could lead to infections or complications, especially if the medicine is used for a long time.
- If this happens, doctors may need to stop treatment.
Risk of Severe Diarrhoea
- A serious bowel condition called pseudomembranous colitis can occur with many antibiotics, including cefuroxime.
- This should be considered if a patient develops diarrhea during or after treatment.
- In such cases, treatment may need to stop, and special medication for Clostridium difficile may be required.
- Anti-diarrheal drugs that slow down the gut should be avoided.
Impact on Lab Tests
- Cefuroxime may cause a positive Coombs test, which can interfere with blood matching for transfusion.
- When checking blood sugar levels, some test methods (like the ferricyanide test) may give false results.
- Instead, it’s best to use the glucose oxidase or hexokinase methods.
Dosages administration of Cefuroxime Axetil Tablet
How to Take a Cefuroxime Axetil Tablet?
- Always take after food for better absorption.
- Do not chew or crush the tablets—they’re coated to mask taste and must be swallowed whole.
- If a patient cannot swallow tablets, they should not use cefuroxime tablets. In such cases, especially in children, use the oral suspension form instead.
Typical Duration of Treatment
- Standard course: 7 days.
- Can vary between 5 and 10 days, depending on the condition.
- Dosing by Age & Weight.
- Adults and children ≥ 40 kg.
| Condition | Dose | Frequency |
| Tonsillitis, Pharyngitis, Sinusitis | 250 mg | Twice daily |
| Otitis Media, Bronchitis (flare-up) | 500 mg | Twice daily |
| Cystitis, Pyelonephritis, Skin Infections | 250 mg | Twice daily |
| Lyme Disease | 500 mg | Twice daily for 14 days (range: 10–21 days) |
Children < 40 kg
| Condition | Dose | Frequency |
|---|---|---|
| Tonsillitis, Pharyngitis, Sinusitis | 10 mg/kg (max 125 mg) | Twice daily |
| Otitis Media, Severe Infections (≥2 years) | 15 mg/kg (max 250 mg) | Twice daily |
| Cystitis, Skin Infections | 15 mg/kg (max 250 mg) | Twice daily |
| Pyelonephritis | 15 mg/kg (max 250 mg) | Twice daily for 10–14 days |
| Lyme Disease | 15 mg/kg (max 250 mg) | Twice daily for 14 days (range: 10–21 days) |
Side effects of Cefuroxime Axetil Tablet
Typical Side Effects of Cefuroxime Axetil Tablet More than 1 in 100 people experience these:
Infections: Candida (yeast) overgrowth.
Blood Problems: Increase white blood cells called eosinophils.
Nervous System: lightheadedness and headache.
Digestive System: pain in the abdomen, nausea, and diarrhea.
Liver Function: A brief rise in liver enzymes that is typically reversible.
Reduced Frequency of Side Effects.
Less than 1 in 100 persons experiences this:
Coombs’ test results are positive, which could affect the results of blood transfusion tests.
Disorders of the Blood Cells: Low white blood cells (leukopenia), low platelets (thrombocytopenia)
Skin: Light rashes.
Digestive: Vomiting.
Rare or Unclear Frequency These are either very rare, or their frequency isn’t known.
Blood Reactions
- Cephalosporins (a group of antibiotics) can stick to red blood cells and may trigger the immune system to react.
- This can result in a positive Coombs’ test, which might complicate finding compatible blood for transfusions.
- In very rare cases, this reaction can lead to hemolytic anemia—a condition where red blood cells break down faster than they’re made.
Liver Effects
- Some people may show a temporary rise in liver enzymes during treatment.
- These changes are typically mild and go away on their own.
Children’s Safety
- The side effects seen in children using cefuroxime axetil are similar to those in adults.
- No special safety concerns reported for pediatric use.
Storage instruction of Cefuroxime Axetil Tablet
Store below 30°C and protect from light and moisture. Keep out of reach of children.
Packing details of Cefuroxime Axetil Tablet
Alu-Alu blister packs.
Cefuroxime Axetil Tablet is available in an Alu-Alu blister of 10 tablets. Such are 10 blisters with package inserts in a unit box.
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