Cefuroxime Axetil Tablet

Therapeutic Class: Anti-Infectives

Dosage Forms: Tablets

Brand Name: CVPROX-500 Tablet

How it works?

Uses of Cefuroxime Axetil Tablet

When you take a cefuroxime axetil tablet, your body uses enzymes called esterases to convert it into its active form, cefuroxime.
Cefuroxime then attaches to special proteins in bacteria called penicillin-binding proteins (PBPs).
These PBPs help bacteria build their cell walls, which are essential for their survival.
By blocking PBPs, cefuroxime stops bacteria from making strong cell walls.
Without proper cell walls, the bacteria break apart and die.

Dosages administration of Cefuroxime Axetil Tablet

How to Take a Cefuroxime Axetil Tablet?

Always take after food for better absorption.
Do not chew or crush the tablets—they’re coated to mask taste and must be swallowed whole.
If a patient cannot swallow tablets, they should not use cefuroxime tablets. In such cases, especially in children, use the oral suspension form instead.

Typical Duration of Treatment

Standard course: 7 days.
Can vary between 5 and 10 days, depending on the condition.
Dosing by Age & Weight.
Adults and children ≥ 40 kg.

Condition	Dose	Frequency
Tonsillitis, Pharyngitis, Sinusitis	250 mg	Twice daily
Otitis Media, Bronchitis (flare-up)	500 mg	Twice daily
Cystitis, Pyelonephritis, Skin Infections	250 mg	Twice daily
Lyme Disease	500 mg	Twice daily for 14 days (range: 10–21 days)

Children < 40 kg

Condition	Dose	Frequency
Tonsillitis, Pharyngitis, Sinusitis	10 mg/kg (max 125 mg)	Twice daily
Otitis Media, Severe Infections (≥2 years)	15 mg/kg (max 250 mg)	Twice daily
Cystitis, Skin Infections	15 mg/kg (max 250 mg)	Twice daily
Pyelonephritis	15 mg/kg (max 250 mg)	Twice daily for 10–14 days
Lyme Disease	15 mg/kg (max 250 mg)	Twice daily for 14 days (range: 10–21 days)

Side effects of Cefuroxime Axetil Tablet

Typical Side Effects of Cefuroxime Axetil Tablet More than 1 in 100 people experience these:

Infections: Candida (yeast) overgrowth.

Blood Problems: Increase white blood cells called eosinophils.

Nervous System: lightheadedness and headache.

Digestive System: pain in the abdomen, nausea, and diarrhea.

Liver Function: A brief rise in liver enzymes that is typically reversible.

Reduced Frequency of Side Effects.
Less than 1 in 100 persons experiences this:

Coombs’ test results are positive, which could affect the results of blood transfusion tests.

Disorders of the Blood Cells: Low white blood cells (leukopenia), low platelets (thrombocytopenia)

Skin: Light rashes.

Digestive: Vomiting.

Rare or Unclear Frequency These are either very rare, or their frequency isn’t known.

Blood Reactions

Cephalosporins (a group of antibiotics) can stick to red blood cells and may trigger the immune system to react.
This can result in a positive Coombs’ test, which might complicate finding compatible blood for transfusions.
In very rare cases, this reaction can lead to hemolytic anemia—a condition where red blood cells break down faster than they’re made.

Liver Effects

Some people may show a temporary rise in liver enzymes during treatment.
These changes are typically mild and go away on their own.

Children’s Safety

The side effects seen in children using cefuroxime axetil are similar to those in adults.
No special safety concerns reported for pediatric use.

Precautions of Cefuroxime Axetil Tablet

Allergy (Hypersensitivity) Risks while taking Cefuroxime Axetil Tablet.

If someone is allergic to penicillins or other beta-lactam antibiotics, they might also react to cefuroxime.
In rare cases, these allergic reactions can be severe or even life-threatening.
If a serious reaction occurs, stop the medicine immediately and seek emergency help.
Before starting treatment, doctors should check if the patient has a history of allergy to cefuroxime or similar antibiotics.

Jarisch-Herxheimer Reaction

This reaction may happen when treating Lyme disease with cefuroxime.
It’s caused by the medicine killing the Lyme disease bacteria (Borrelia burgdorferi).
Symptoms may include fever, chills, or muscle pain—but they are usually short-lived and harmless.
Patients should be informed that this is a normal response during treatment.

Overgrowth of Unwanted Germs

Like other antibiotics, cefuroxime may allow Candida or other bacteria (enterococci, Clostridium difficile) to grow too much.
This could lead to infections or complications, especially if the medicine is used for a long time.
If this happens, doctors may need to stop treatment.

Risk of Severe Diarrhoea

A serious bowel condition called pseudomembranous colitis can occur with many antibiotics, including cefuroxime.
This should be considered if a patient develops diarrhea during or after treatment.
In such cases, treatment may need to stop, and special medication for Clostridium difficile may be required.
Anti-diarrheal drugs that slow down the gut should be avoided.

Impact on Lab Tests

Cefuroxime may cause a positive Coombs test, which can interfere with blood matching for transfusion.
When checking blood sugar levels, some test methods (like the ferricyanide test) may give false results.
Instead, it’s best to use the glucose oxidase or hexokinase methods.

Storage instruction of Cefuroxime Axetil Tablet

Store below 30°C and protect from light and moisture. Keep out of reach of children.

Packing details of Cefuroxime Axetil Tablet

Alu-Alu blister packs.

Cefuroxime Axetil Tablet is available in an Alu-Alu blister of 10 tablets. Such are 10 blisters with package inserts in a unit box.

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