Cefuroxime Axetil Tablet

Therapeutic Class: Anti-Infectives

Dosage Forms: Tablets

Brand Name: CVPROX-500 Tablet

Cefuroxime Axetil Tablet manufacturer, supplier & exporter in India

How it works?

Uses of Cefuroxime Axetil Tablet

  • When you take a cefuroxime axetil tablet, your body uses enzymes called esterases to convert it into its active form—cefuroxime.
  • Cefuroxime then attaches to special proteins in bacteria called penicillin-binding proteins (PBPs).
  • These PBPs help bacteria build their cell walls, which are essential for their survival.
  • By blocking PBPs, cefuroxime stops bacteria from making strong cell walls.
  • Without proper cell walls, the bacteria break apart and die.

Dosages administration of Cefuroxime Axetil Tablet

How to Take Cefuroxime Axetil Tablet

  • Always take after food for better absorption.
  • Do not chew or crush the tablets—they’re coated to mask taste and must be swallowed whole.
  • If a patient cannot swallow tablets, they should not use cefuroxime tablets. In such cases, especially in children, use the oral suspension form instead.

Typical Duration of Treatment

  • Standard course: 7 days
  • Can vary between 5 and 10 days, depending on the condition.
  • Dosing by Age & Weight
  • Adults and Children ≥ 40 kg
Condition Dose Frequency
Tonsillitis, Pharyngitis, Sinusitis 250 mg Twice daily
Otitis Media, Bronchitis (flare-up) 500 mg Twice daily
Cystitis, Pyelonephritis, Skin Infections 250 mg Twice daily
Lyme Disease 500 mg Twice daily for 14 days (range: 10–21 days)

Children < 40 kg

Condition Dose Frequency
Tonsillitis, Pharyngitis, Sinusitis 10 mg/kg (max 125 mg) Twice daily
Otitis Media, Severe Infections (≥2 years) 15 mg/kg (max 250 mg) Twice daily
Cystitis, Skin Infections 15 mg/kg (max 250 mg) Twice daily
Pyelonephritis 15 mg/kg (max 250 mg) Twice daily for 10–14 days
Lyme Disease 15 mg/kg (max 250 mg) Twice daily for 14 days (range: 10–21 days)

 

Side effects of Cefuroxime Axetil Tablet

Typical Side Effects of Cefuroxime Axetil Tablet More than 1 in 100 people experience these:

Infections: Candida (yeast) overgrowth

Blood Problems: Increase white blood cells called eosinophils

Nervous System: lightheadedness and headache

Digestive System: pain in the abdomen, nausea, and diarrhea

Liver Function: A brief rise in liver enzymes that is typically reversible

Reduced Frequency of Side Effects
Less than 1 in 100 persons experiences this:

Coombs’ test results are positive, which could affect the results of blood transfusion tests.

Disorders of the Blood Cells: Low white blood cells (leukopenia), low platelets (thrombocytopenia)

Skin: Light rashes

Digestive: Vomiting

Rare or Unclear Frequency These are either very rare, or their frequency isn’t known.

Blood Reactions

  • Cephalosporins (a group of antibiotics) can stick to red blood cells and may trigger the immune system to react.
  • This can result in a positive Coombs’ test, which might complicate finding compatible blood for transfusions.
  • In very rare cases, this reaction can lead to hemolytic anemia—a condition where red blood cells break down faster than they’re made.

Liver Effects

  • Some people may show a temporary rise in liver enzymes during treatment.
  • These changes are typically mild and go away on their own.

Children’s Safety

  • The side effects seen in children using cefuroxime axetil are similar to those in adults.
  • No special safety concerns reported for pediatric use.

Precautions of Cefuroxime Axetil Tablet

Allergy (Hypersensitivity) Risks while taking Cefuroxime Axetil Tablet

  • If someone is allergic to penicillins or other beta-lactam antibiotics, they might also react to cefuroxime.
  • In rare cases, these allergic reactions can be severe or even life-threatening.
  • If a serious reaction occurs, stop the medicine immediately and seek emergency help.
  • Before starting treatment, doctors should check if the patient has a history of allergy to cefuroxime or similar antibiotics.

 Jarisch-Herxheimer Reaction

  • This reaction may happen when treating Lyme disease with cefuroxime.
  • It’s caused by the medicine killing the Lyme disease bacteria (Borrelia burgdorferi).
  • Symptoms may include fever, chills, or muscle pain—but they are usually short-lived and harmless.
  • Patients should be informed that this is a normal response during treatment.

 Overgrowth of Unwanted Germs

  • Like other antibiotics, cefuroxime may allow Candida or other bacteria (enterococci, Clostridium difficile) to grow too much.
  • This could lead to infections or complications, especially if the medicine is used for a long time.
  • If this happens, doctors may need to stop treatment.

 Risk of Severe Diarrhoea

  • A serious bowel condition called pseudomembranous colitis can occur with many antibiotics, including cefuroxime.
  • This should be considered if a patient develops diarrhea during or after treatment.
  • In such cases, treatment may need to stop, and special medication for Clostridium difficile may be required.
  • Anti-diarrheal drugs that slow down the gut should be avoided.

 Impact on Lab Tests

  • Cefuroxime may cause a positive Coombs test, which can interfere with blood matching for transfusion.
  • When checking blood sugar levels, some test methods (like the ferricyanide test) may give false results.
  • Instead, it’s best to use the glucose oxidase or hexokinase methods.

Storage instruction of Cefuroxime Axetil Tablet

Store below 30°C and protect from light and moisture. Keep out of reach of children.

Packing details of Cefuroxime Axetil Tablet

Alu-Alu blister packs.

Cefuroxime Axetil Tablet is available in an Alu-Alu blister of 10 tablets. Such 10 blisters with package inserts in a unit box.

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