Ceftriaxone For Injection 1g
Ceftriaxone For Injection USP 1000 mg
Therapeutic Class: Anti-Infectives
Dosage Forms: Injectables
Brand Name: Ceftriaxone For Injection USP 1000 mg™
How it works?
Uses of Ceftriaxone For Injection 1g
Ceftriaxone Injection Common Uses:
A strong antibiotic called ceftriaxone injection is used to treat severe bacterial infections. It is known to be effective against a wide variety of bacteria and is a member of the class of medications known as cephalosporins.
It helps your body fight off the infection more successfully by preventing bacteria from building their defense walls.
In hospitals, it is frequently used to treat infections such as pneumonia, meningitis, and urinary tract infections. Doctors typically administer it intravenously (IV) or intramuscularly (IM). In order to help prevent infections, it is also used prior to some surgeries.
It treats different infections such as
- Respiratory Tract Infections: Treats pneumonia, bronchitis, and other lower respiratory infections.
- Central Nervous System Infections: Effective against bacterial meningitis and other brain/spinal cord infections.
- Urinary Tract Infections (UTIs): Used for both uncomplicated and complicated UTIs.
- Skin and Soft Tissue Infections: Treats cellulitis, abscesses, and wound infections.
- Bone and Joint Infections: Used in osteomyelitis and septic arthritis.
- Sexually Transmitted Infections (STIs): Highly effective against gonorrhea and other bacterial STIs.
- Pelvic Inflammatory Disease (PID): Often part of combination therapy for PID.
- Septicemia (Bloodstream Infections): Used in life-threatening systemic infections.
- Ear Infections: Treats acute otitis media, especially in children.
- Heart Infections: Used in bacterial endocarditis treatment.
- Gastrointestinal Infections: Treats infections like typhoid fever and spontaneous bacterial peritonitis.
- Surgical Prophylaxis Administered before surgery to prevent postoperative infections.
How to Prepare & Use Ceftriaxone Injection 1 g:
Reconstitution, or the preparation for use: Preparation of solutions for injection and infusion:
| Powder | Reconstitution solvent | Volume to be added | Approx. displacement volume | |
| Intravenous Injection | 250 mg | Water for Injections | 2.5 ml | 0.2 ml |
| 1 g | Water for Injections | 10 ml | 0.6 ml | |
| Intramuscular injection | 250 mg | 1.0% Lidocaine Hydrochloride | 1.0 ml | 0.06 ml |
| 1 g | 1.0% Lidocaine Hydrochloride | 3.5 ml | 0.66 ml | |
| Intravenous infusion | 2 g | Glucose Injection 5% or 10%, 0.9% Sodium Chloride Injection, Sodium Chloride and Glucose Injection (0.45% Sodium Chloride and 2.5% Glucose), and Dextran 6% in Glucose Injection 5%. | 40.0 ml | 1.2 ml |
The recommended use of Ceftriaxone Injection 1 g is the freshly prepared solution. Solutions to be reconstituted should be stored at 2-8°C for 24 hours and at less than 25°C for 6 hours. The reconstituted solution must be used immediately upon preparation.
Ceftriaxone injection 1 g should not be combined in the same syringe with any medication except 1% lidocaine hydrochloride solution (only for intramuscular administration). The infusion line must be flushed after each use.
Precautions of Ceftriaxone For Injection 1g
Precautions while taking Ceftriaxone For Injection 1 g
Hypersensitivity reactions
As with all antibacterial beta-lactam drugs, there have been serious and occasionally fatal hypersensitivity reactions. In the event of hypersensitivity reactions, administration of ceftriaxone should be stopped at once and appropriate emergency therapy should be initiated.
Immune-mediated haemolytic anaemia Immune-mediated hemolytic anemia has been reported in patients on cephalosporin-class antibacterials such as ceftriaxone. The cases of hemolytic anemia, including fatalities, have occurred during treatment with ceftriaxone in adults and children.
Antibacterial spectrum Ceftriaxone has a limited spectrum of antibacterial activity and may not be suitable for use as a single agent for the treatment of some types of infections unless the pathogen has already been confirmed.
Renal lithiasis
Renal lithiasis cases have been observed, which are reversible if ceftriaxone is discontinued.
Jarisch-Herxheimer reaction (JHR)
It may cause a Jarisch-Herxheimer reaction (JHR) in some patients with spirochete infection shortly after initiating ceftriaxone therapy. JHR is a self-limiting condition in most instances or can be treated symptomatically. The antibiotic therapy must not be stopped if such a reaction does take place.
Encephalopathy
Encephalopathy has been associated with the administration of ceftriaxone, especially in older patients with serious renal impairment or central nervous system disease.
Dosages administration of Ceftriaxone For Injection 1g
Ceftriaxone Injection Dose:
The dose depends on the severity, susceptibility, site, and type of infection and on the age and hepatorenal function of the patient.
The doses recommended in the tables below are the generally recommended doses in these indications. In particularly severe cases, doses at the higher end of the recommended range should be considered.
Adults and children over 12 years of age (≥ 50 kg)
| Ceftriaxone Dosage | Treatment frequency | Indications |
| 1-2 g | Once daily |
|
| 2 g | Once daily |
|
| 2-4 g | Once daily |
|
Split doses (every 12 hours) may be used when the total daily dose exceeds 2 g. > In bloodstream infections (bacteremia), aim for the higher end of the dosing range.
Special Cases for Adults & Older Children
| No | Condition | Recommended Dose |
| 1 | Acute ear infection (Otitis Media) | Single IM dose of 1–2 g; if severe, once daily for 3 days |
| 2 | Surgical Infection Prevention | 2 g as a one-time dose before surgery |
| 3 | Gonorrhea | 500 mg IM, single dose |
| 4 | Syphilis | 500 mg–1 g once daily; increase to 2 g for neurosyphilis (10–14 days) |
| 5 | Lyme disease (Stage II/III) | 2 g once daily for 14–21 days |
Pediatric Patients (15 days to 12 years old, under 50 kg)
Standard Dosing
| Dose | Frequency | Indications |
| 50–80 mg/kg | Once daily | Intra-abdominal infections Pneumonia UTIs |
| 50–100 mg/kg (Max 4 g) | Once daily | Skin, bone, or joint infections— Fever with suspected bacterial cause |
| 80–100 mg/kg (Max 4 g) | Once daily | Bacterial meningitis |
| 100 mg/kg (Max 4 g) | Once daily | Bacterial endocarditis |
In severe cases or if blood infection is confirmed, use higher doses within the range. > If the total dose exceeds 2 g/day, consider administering in two doses (every 12 hours).
Special Pediatric Use
| Condition | Suggested Dosage |
|---|---|
| Ear infections | One-time IM dose of 50 mg/kg; daily for 3 days if needed |
| Surgery prevention | 50–80 mg/kg as a single pre-op dose |
| Syphilis | 75–100 mg/kg (max 4 g) once daily for 10–14 days |
| Lyme disease (Stage II/III) | 50–80 mg/kg daily for 14–21 days |
Newborns (0–14 days)
Do NOT use ceftriaxone in premature neonates under 41 weeks postmenstrual age (gestational + actual age combined).
Dosing Guidelines
| Dose | Frequency | Conditions Treated |
| 20–50 mg/kg | Once daily | Intra-abdominal, urinary, lung, skin, or bone infections |
| 50 mg/kg | Once daily | – Meningitis – Endocarditis |
Never exceed 50 mg/kg/day in this age group. Higher ranges should be reserved for severe or bloodstream infections.
Side effects of Ceftriaxone For Injection 1g
Ceftriaxone Injection Side Effects
Most Commonly Reported Side Effects
These reactions were most frequently seen in clinical studies:
- High white blood cell count (eosinophilia)
- Low white blood cell count (leukopenia)
- Low platelet count (thrombocytopenia)
- Diarrhea
- Skin rash
- Elevated liver enzymes
How Ceftriaxone Injection Side Effects Are Categorized
Ceftriaxone side effects are grouped based on how frequently they occur:
| Frequency Category | Definition |
|---|---|
| Very common | Happens in more than 1 in 10 people |
| Common | Happens in 1 to 10 out of every 100 people |
| Uncommon | Happens in 1 to 10 out of every 1,000 people |
| Rare | Happens in 1 to 10 out of every 10,000 people |
| Not known | Reported, but exact frequency cannot be estimated |
Detailed Overview by Body System
Infections
- Uncommon: Yeast infections (e.g., genital fungal infection)
- Rare: Severe intestinal infection (pseudomembranous colitis)
Blood & Immune Cells
- Common: Eosinophilia, leukopenia, thrombocytopenia
- Uncommon: Low red blood cells (anaemia), clotting issues (coagulopathy), low neutrophils (granulocytopenia)
- Not known: severe anemia (haemolytic), severe white cell loss (agranulocytosis)
Immune System Reactions
- Not known: Severe allergic reactions like anaphylaxis or hypersensitivity
Nervous System
- Uncommon: Headaches, dizziness
- Rare: Brain-related issues (encephalopathy)
Digestive System
- Common: Diarrhea, loose stools
- Uncommon: Nausea, vomiting
- Not known: Inflamed pancreas (pancreatitis), mouth sores (stomatitis)
Liver & Gallbladder
- Common: Elevated liver enzymes
- Not known: Gallstones or sludge, jaundice in newborns (kernicterus), hepatitis
Skin
- Common: Rash
- Not known: Serious skin conditions (e.g., Stevens-Johnson Syndrome, toxic epidermal necrolysis)
Kidneys & Urinary Tract
- Rare: Blood in urine (haematuria), sugar in urine (glycosuria)
- Not known: Reduced urine output (oliguria), reversible kidney precipitation
Storage instruction of Ceftriaxone For Injection 1g
Store below 30°C. Protect from light and moisture. Keep the medicine out of reach of children.
Packing details of Ceftriaxone For Injection 1g
10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal. Ceftriaxone For Injection 1 g of powder for solution for injection or infusion is supplied in a glass vial packed in a unit carton with a pack insert.
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