Cefepime and Sulbactam Injection 1500mg

Cefepime & Sulbactam Injection 1500 mg

Therapeutic Class: Anti-Infectives

Dosage Forms: Injectables

Brand Name: Cefepime & Sulbactam Injection 1500 mg™

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Uses of Cefepime and Sulbactam Injection 1500mg

This injection is used to treat a wide range of bacterial infections, such as

  • Lung infections (like pneumonia)
  • Urinary tract infections (UTIs)
  • Skin infections.
  • Infections in the abdomen.
  • Serious hospital-acquired infections.

Doctors prescribe it when infections are caused by bacteria that may resist regular antibiotics.

Precautions of Cefepime and Sulbactam Injection 1500mg

Precautions Before and During Use of Cefepime/Sulbactam Injection 1500mg

 Infection-Related

  • Only prescribe this injection when there’s a confirmed or strongly suspected bacterial infection to avoid contributing to antibiotic resistance.

 Blood Clotting

  • May reduce prothrombin activity, increasing bleeding risk—especially in:
    • Patients with kidney or liver problems
    • Those with poor nutrition
    • Individuals on long-term antibiotic treatment

 Lab Effects

  • May cause a positive Coombs’ test, indicating changes to red blood cells.

 Metabolism & Potassium

  • High levels of arginine (far beyond the recommended dose) may temporarily affect blood sugar and increase potassium levels.

 Genetic & Fertility Safety

  • No cancer studies done in animals.
  • Some lab tests showed DNA effects; others did not.
  • No fertility issues were observed in animal studies at high doses.

 Pregnancy & Breastfeeding

  • Pregnancy: Safety is not confirmed—only use if absolutely necessary.
  • Nursing mothers: The drug is present in breast milk in small amounts—use with caution.

 Geriatric Use

  • Safe for healthy older adults.
  • Serious side effects (like confusion and seizures) can occur in elderly patients with kidney problems receiving incorrect doses.
  • Dose adjustment and kidney function monitoring are critical.

Dosages administration of Cefepime and Sulbactam Injection 1500mg

Easy Guide to Dosage for Cefepime With Sulbactam Injection 1500mg

  • This injection contains 1.5 grams of medicine in each vial.
  • Doctors usually give it 2 or 3 times a day, depending on how bad the infection is.
  • The highest daily amount is 9 grams, split into smaller doses throughout the day.

For People With Kidney Problems

  • If your kidneys aren’t working well, your body may not remove the medicine properly.
  • So, doctors will give you a smaller dose to keep things safe.
  • To check your kidney health, doctors use blood tests (called serum creatinine) or a number called creatinine clearance.
  • There’s even a simple formula doctors use to figure it out based on your age, weight, and sex.

When only serum creatinine is available, the following formula (based on the sex, weight, and age of the patient) may be used to convert this value in to creatinine clearance.

Males: Weight in (kg) x (140 – age) / 72 x Serum creatinine

Females: (0.85) x (above value)

Preparation of Solutions of Cefepime & Sulbactam Injection 1500 mg

Single-dose vials for IV/IM administration Amount of Diluent to be added (ml) Approximate available volume (ml) Approximate cefepime and sulbactam concentration (mg/ml)
0.75 g (IV) 5.0 5.9 80/40
0.75 g (IM) 1.5 2.2 228/114
1.5 g (IV) 10 11.4 90/43
1.5 g (IM) 2.5 4.0 250/125
3.0 g (IV) 10 12.3 160/80

 

Side effects of Cefepime and Sulbactam Injection 1500mg

Common side effect (seen in 1% or more patients):

  • Pain, redness, or swelling at the injection site (phlebitis or inflammation)
  • Skin rash

Less Common (seen in 0.1% to less than 1% of patients):

  • Digestive issues like diarrhoea, nausea, vomiting, or colitis
  • Fever or headache
  • Fungal infections such as oral thrush (oral moniliasis) or vaginal yeast infections (vaginitis)
  • Skin-related symptoms like itching (pruritus), hives (urticaria)

Possible Reactions Known with Cephalosporin Antibiotics (class effects)

These are less frequent but potentially serious and should be monitored:

  • Blood-related changes: low white cells (leukopenia, neutropenia, agranulocytosis), low platelets (thrombocytopenia), anemia (aplastic, hemolytic), or bleeding issues
  • Severe skin reactions: Stevens-Johnson syndrome, toxic skin peeling (toxic epidermal necrolysis), red patches or spots (erythema multiforme)
  • Kidney problems: temporary or toxic renal dysfunction
  • Liver issues: including blockage in bile flow (cholestasis)
  • Pancytopenia: reduction in all types of blood cells.

Storage instruction of Cefepime and Sulbactam Injection 1500mg

Store below 30°C temperature. Protect from light.

Keep the medicine out of reach of children.

Packing details of Cefepime and Sulbactam Injection 1500mg

10 ml clear glass vial with bromobutyl rubber stopper, sealed with a flip-off aluminum seal.

Cefepime & Sulbactam Injection 1500 mg in a glass vial is supplied with a 10 ml plastic ampoule of diluent Sterilized Water for Injections USP in a unit carton with a pack insert.

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