Metronidazole Suppository 500mg
- Metronidazole Ovules 500 mg
Therapeutic Class: Anti-Infectives
Dosage Forms: Suppositiries
Brand Name: Vogyna-M™
How it works?
Uses of Metronidazole Suppository 500mg
Metronidazole Ovules 500 mg (e.g., Vogyna-M) are used as a local treatment inside the vagina.
- They primarily treat bacterial vaginosis by targeting harmful anaerobic bacteria that cause infections.
- They are effective against Trichomonas vaginalis, a parasite that causes discharge, irritation, and discomfort.
- The ovules deliver the medicine directly to the infection site, working locally.
- This local action reduces side effects compared to taking oral tablets because less medicine enters the whole body.
- Overall, they help restore vaginal balance and relieve infection symptoms efficiently and gently.
Precautions of Metronidazole Suppository 500mg
Where there is evidence of trichomonal infestation in the sexual partner, he should be treated concomitantly with oral metronidazole to avoid reinfestation.
The effectiveness of condoms or diaphragms could be impaired by some of the fatty constituents contained in metronidazole gynaecological ovule, therefore their use during Vogyna-M treatment is not recommended.
Vaginal injection, menstrual tampons and soaps with an acid pH (for personal hygiene use) should not be used during treatment because they may promote fungal replication.
It is possible that adverse effects normally associated with oral administration of metronidazole may occur following the vaginal administration of Vogyna-M.
Patients should be warned against consuming alcohol, during Vogyna-M therapy and for at least one day afterward, because of a possible disulfiram-like reaction related to the metronidazole.
Although no persistent hematologic abnormalities have been observed in clinical studies, total and differential leukocyte counts should be made before and after treatment, especially if a second course of metronidazole therapy is needed.
Patients should be monitored for adverse reactions such as peripheral or central neuropathy (such as paresthesia, ataxia, dizziness, and convulsive seizures) related to metronidazole.
Vogyna-M should be used with caution in patients with active or chronic severe peripheral and central nervous system diseases due to the risk of neurological aggravation related to metronidazole.
Treatment with metronidazole should be discontinued if ataxia or any other symptom of CNS involvement occurs.
Dosages administration of Metronidazole Suppository 500mg
One vaginal ovule, inserted deep into the vagina, for 10 consecutive days.
If after 10 days of treatment a cure has not been achieved, a second 10-day course of treatment should be given.
If Trichomonas vaginalis has not been eliminated, oral metronidazole 250 mg b.i.d. should be administered for 10 days.
The applicator should not be used after the 7th month of pregnancy.
Vogyna-M should be used for vaginal application only. Insert the ovule using the applicator provided inside the carton of Vogyna-M.
Side effects of Metronidazole Suppository 500mg
Side effects from using Vogyna-M locally are rare and usually mild, such as vaginal burning or a granular feeling.
Bitter taste, nausea, and vomiting mostly happen when oral Metronidazole is taken at the same time as Vogyna-M.
Other side effects are typically seen with oral or intravenous (I.V.) Metronidazole, including:
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- Blood and lymphatic system: Temporary changes like increased eosinophils, low neutrophils, and rare cases of low white blood cells or platelets.
- Heart: Palpitations and chest pain.
- Eyes: Temporary vision problems like double vision, blurred or decreased vision, color changes, and rare cases of optic nerve inflammation.
- Stomach and digestion: Diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, constipation, dry mouth, metallic taste, coated tongue, and mouth sores. Rarely, pancreatitis (inflammation of the pancreas) can occur.
- General and injection site issues: Blood clots in veins from I.V. use (thrombophlebitis) and fever.
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These side effects are mostly linked to systemic (oral or I.V.) use rather than local vaginal treatment.
Storage instruction of Metronidazole Suppository 500mg
Store in cool and dry place at temperature below 25 °C and protect from light.
Keep the medicine out of reach of children.
Packing details of Metronidazole Suppository 500mg
Aluminum strip pack
Vogyna-M is available in an Aluminum strip (laminated with paper) of 5 ovules. Such a strip is in a unit carton with a package insert and applicator.
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Renowned GMP Certified Metronidazole Suppository 500mg Manufacturer
At Conical Pharmaceuticals, we are a trusted manufacturer of Metronidazole Suppository 500 mg, produced at our GMP‑certified large‑scale facility in Ahmedabad, India.
We also manufacture a wide range of antibiotic formulations, including antibiotic tablets, injections, and suppositories for distributors, importers, private label brands, retail chains, and pharmacies. With expertise in custom formulations and packaging, we deliver consistent quality and reliable supply to global healthcare partners.
Metronidazole Suppository 500 mg is widely demanded worldwide due to its proven effectiveness against amoebiasis, giardiasis, trichomoniasis, and anaerobic bacterial infections.
In many countries, suppository dosage forms are preferred for patients with gastrointestinal intolerance, pediatric care, or hospital protocols, driving large‑scale demand in institutional and tender markets.
We are recognized as a global exporter of suppository ovules, with strong distribution planning across Central America (Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama), Central Africa (Cameroon, Chad, DRC, Equatorial Guinea, Gabon, Republic of the Congo), the CIS countries, and key markets such as Iraq, Iran, Malaysia, Thailand, and Saudi Arabia.
To ensure smooth import processes, we provide complete documentation including GMP Certificate, Free Sale Certificate, COPP, COA, and tailored dossiers. Backed by 15+ years of experience and 7+ large‑scale CMO sites, we deliver confidence in every collaboration.
Global exporter of Metronidazole Suppository 500 mg
Secure institutional procurement with GMP‑certified quality.
CUSTOM PACKAGING
Options available in size and style to meet your exact specifications and branding needs
SAMPLES AVAILABLE
Test before committing to bulk orders with complimentary samples for quality verification
LEAD TIME
45–60 days for timely delivery, ensuring reliable supply chain management
SHELF LIFE
Shelf Life: 24 months.
Frequently Asked Questions
Questions are useful tools, they open lines of communication; give us information; improve interactions, facilitate analysis, and many more.
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It is inserted rectally or vaginally, as directed by a healthcare professional. Dosage and duration depend on the type and severity of infection.
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