Naproxen and Sumatriptan Tablets
- Naproxen and Sumatriptan Tablets
Therapeutic Class: Pain Management
Dosage Forms: Tablets
Brand Name: S-Meprox™
How it works?
Uses of Naproxen and Sumatriptan Tablets
- Migraine treatment → Use only if a clear diagnosis of migraine headache has been established.
- First attack response → If there is no response to the first treated migraine, reconsider the diagnosis before using for subsequent attacks.
- Not for prevention → This combination is not indicated for the prevention of migraine attacks.
- Not for cluster headache → Safety and effectiveness have not been established for cluster headache.
Precautions of Naproxen and Sumatriptan Tablets
- Ischemic or vasospastic CAD → Contraindicated in patients with coronary artery disease and in those undergoing CABG surgery due to increased risk of serious cardiovascular events.
- Cardiovascular events with sumatriptan → Rare reports of acute myocardial infarction within hours of use, even in patients without known CAD. May cause coronary artery vasospasm (Prinzmetal’s angina).
- Cardiovascular thrombotic events with NSAIDs → Long‑term trials show increased risk of heart attack and stroke, which can be fatal.
- GI bleeding, ulceration, perforation → Naproxen can cause serious gastrointestinal damage, including bleeding, ulcers, and perforation of the stomach or intestines.
- Chest, throat, neck, jaw pain → Tightness, heaviness, or pain may occur after sumatriptan use; contraindicated in CAD and Prinzmetal’s angina.
- Hypertension → Both sumatriptan and naproxen can cause significant increases in blood pressure or worsen existing hypertension, raising cardiovascular risk.
Dosages administration of Naproxen and Sumatriptan Tablets
Adults
The recommended dosage for adults is 1 tablet of Naproxen and Sumatriptan Tablets 500 mg/85 mg. Naproxen and Sumatriptan Tablets 500 mg/85 mg contains a dose of sumatriptan higher than the lowest effective dose.
The choice of the dose of sumatriptan, and of the use of a fixed combination such as in Naproxen and Sumatriptan Tablets 500 mg/85 mg should be made on an individual basis, weighing the possible benefit of a higher dose of sumatriptan with the potential for a greater risk of adverse reactions.
The maximum recommended dosage in a 24-hour period is 2 tablets, taken at least 2 hours apart. The safety of treating an average of more than 5 migraine headaches in adults in a 30-day period has not been established.
Side effects of Naproxen and Sumatriptan Tablets
- Cardiovascular thrombotic events → Risk of heart attack or stroke.
- Arrhythmias → Irregular heartbeat.
- Chest, throat, neck, jaw pain → Tightness or pressure requiring urgent evaluation.
- Cerebrovascular events → Stroke or transient ischemic attacks.
- Other vasospasm reactions → Narrowing of blood vessels leading to complications.
- Hypertension → Elevated blood pressure.
- Heart failure & edema → Fluid retention and worsening cardiac function.
- GI bleeding, ulceration, perforation → Serious stomach or intestinal damage.
- Medication overuse headache → Worsening headache with frequent use.
- Serotonin syndrome → Life‑threatening reaction with confusion, agitation, rapid heart rate.
- Hepatotoxicity → Liver damage requiring monitoring.
- Renal toxicity & hyperkalemia → Kidney impairment and elevated potassium levels.
- Anaphylactic reactions → Severe allergic response.
- Serious skin reactions → Stevens‑Johnson syndrome, toxic epidermal necrolysis.
- Drug reaction with eosinophilia & systemic symptoms (DRESS) → Severe immune reaction with rash, fever, organ involvement.
- Hematological toxicity → Blood disorders such as anemia or low platelets.
- Asthma exacerbation related to aspirin sensitivity → Worsening respiratory symptoms in sensitive patients.
Storage instruction of Naproxen and Sumatriptan Tablets
Store below 30°C. Protect from light and moisture.
Keep the medicine out of reach of children.
Packing details of Naproxen and Sumatriptan Tablets
10 × 1 × 10 Alu/PVC Blister.
S-MEPROX tablets are available in an Alu/PVC blister of 10 tablets. Such 1 blister in a monocarton and Such 10 monocartons in a unit carton with pack insert.
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Top GMP Certified Naproxen and Sumatriptan Tablets Manufacturer
Conical Pharmaceuticals, headquartered in Ahmedabad, India, is a GMP‑certified manufacturer & exporter of Naproxen + Sumatriptan Tablets, delivering premium pharmaceutical and nutraceutical solutions worldwide.
Belonging to the migraine therapeutic class, this fixed‑dose combination is indicated for the acute treatment of migraine attacks in adults. It is not intended for prevention of migraines or for cluster headaches. Naproxen provides anti‑inflammatory and analgesic action, while Sumatriptan offers selective 5‑HT1 receptor agonist activity to relieve migraine pain and associated symptoms. Conical Pharmaceutical has successfully registered Naproxen + Sumatriptan Tablets in Kenya.
With exports planned into Central Africa, Central America, and the CIS Region, and expanding into Nigeria, Ghana, Zambia, Zimbabwe, Kenya, the Philippines, Singapore, and Afghanistan, Conical Pharmaceuticals ensures reliable supply and smooth market entry. Importers benefit from complete regulatory dossier support, including GMP Certification, COPP, COA, and Free Sale Certificates.
We also provide third‑party contract manufacturing, bulk supply of pharmaceutical tablets, private labelling, and custom formulation options, empowering partners to launch their own brands with tailored solutions. With advanced R&D, flexible MOQ options, and consistent quality assurance, Conical Pharmaceuticals enables partners to expand their market presence while delivering effective, high‑quality migraine therapies worldwide.
CUSTOM PACKAGING
Options available in size and style to meet your exact specifications and branding needs
SAMPLES AVAILABLE
Test before committing to bulk orders with complimentary samples for quality verification
LEAD TIME
45–60 days for timely delivery, ensuring reliable supply chain management
SHELF LIFE
Shelf Life: 24 months.
Frequently Asked Questions
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Conical Pharmaceuticals, headquartered in Ahmedabad, India, is a GMP‑certified manufacturer & exporter of Naproxen + Sumatriptan Tablets.
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