Pregabalin and Nortriptyline Tablets
- Pregabalin and Nortriptyline Tablets
Therapeutic Class: Pain Management
Dosage Forms: Tablets
Brand Name: Prenor™
How it works?
Uses of Pregabalin and Nortriptyline Tablets
Uses of Pregabalin and Nortriptyline Tablets
- Peripheral neuropathic pain Indicated for the treatment of nerve pain caused by conditions such as diabetic neuropathy, post‑herpetic neuralgia, or nerve compression.
- Central neuropathic pain Effective in managing pain arising from central nervous system injuries or disorders, including spinal cord injury and multiple sclerosis.
- Generalized Anxiety Disorder (GAD) Pregabalin + Nortriptyline Tablets are indicated for the treatment of GAD in adults, helping reduce excessive worry, restlessness, and associated symptoms.
Precautions of Pregabalin and Nortriptyline Tablets
Precaution while taking Pregabalin and Nortriptyline Tablets
- Weight gain in diabetics Some diabetic patients who gain weight on pregabalin may need adjustment of hypoglycemic medications.
- Angioedema risk Pregabalin should be discontinued immediately if facial, perioral, or upper airway swelling occurs.
- Dizziness & somnolence These effects may increase risk of accidental injury (falls), especially in elderly patients.
- Withdrawal symptoms Stopping pregabalin may cause insomnia, headache, nausea, anxiety, Diarrhoea, flu‑like symptoms, depression, pain, convulsions, hyperhidrosis, and dizziness. Patients should be informed about this risk at treatment initiation.
- Convulsions Seizures, including status epilepticus and grand mal convulsions, may occur during use or shortly after discontinuation.
- Spinal cord injury patients Higher incidence of CNS adverse reactions (especially somnolence) due to additive effects with concomitant anti‑spasticity medications.
- Congestive heart failure Reported in elderly cardiovascular‑compromised patients. Use with caution; discontinuation may resolve symptoms.
- Suicidal ideation Cases of suicidal thoughts and behaviour have been reported with antiepileptic drugs, including pregabalin.
- Misuse, abuse & dependence Caution in patients with history of substance abuse. Monitor for tolerance, dose escalation, and drug‑seeking behaviour.
- Encephalopathy Cases reported, mostly in patients with underlying conditions that predispose to encephalopathy.
- Nortriptyline cardiovascular risk Use only under close supervision in patients with cardiovascular disease due to risk of sinus tachycardia, conduction delay, myocardial infarction, arrhythmia, and stroke.
- Nortriptyline thyroid caution Great care is needed in hyperthyroid patients or those on thyroid medication, as cardiac arrhythmias may develop.
Dosages administration of Pregabalin and Nortriptyline Tablets
- Initial dose Treatment can be started at 150 mg per day, given in two or three divided doses.
- Titration schedule Based on patient response and tolerability:
- Increase to 300 mg per day after 3–7 days.
- If needed, increase to a maximum of 600 mg per day after an additional 7‑day interval.
- Generalised Anxiety Disorder (GAD) Treatment should be reassessed regularly to confirm ongoing need.
- Renal impairment Pregabalin clearance is directly proportional to creatinine clearance. Dose reduction must be individualized according to renal function.
- Elderly patients May require dose reduction due to decreased renal function.
Side effects of Pregabalin and Nortriptyline Tablets
Side effect of Pregabalin and Nortriptyline Tablets
- Neurological effects Dizziness, somnolence, headache, ataxia, abnormal coordination, tremor, dysarthria, amnesia, memory impairment, disturbance in attention, paranesthesia, hypoesthesia, sedation, balance disorder, lethargy.
- Psychiatric effects Euphoric mood, confusion, irritability, disorientation, insomnia, decreased libido.
- ENT effects Nasopharyngitis.
- Visual effects Blurred vision, diplopia (double vision).
- Gastrointestinal effects Vomiting, nausea, constipation, Diarrhoea, flatulence, abdominal distension, dry mouth.
- Metabolic effects Increased appetite.
Storage instruction of Pregabalin and Nortriptyline Tablets
Store below 30°C and protect from light and moisture.
Keep the medicine out of reach of children.
Packing details of Pregabalin and Nortriptyline Tablets
Alu-PVC blister pack.
Prenor is available in an Alu-PVC blister of 10 tablets. Such 03 blisters in a unit carton with package insert.
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Top GMP Certified Pregabalin and Nortriptyline Tablets Manufacturer
Conical Pharmaceuticals, headquartered in Ahmedabad, India, is a GMP‑certified manufacturer & exporter of Pregabalin and Nortriptyline Tablets, delivering premium pharmaceutical and nutraceutical solutions worldwide. Belonging to the neuropathic pain & anxiety therapeutic class, this formulation provides effective relief for peripheral and central neuropathic pain and is also indicated for Generalized Anxiety Disorder (GAD) in adults. Conical Pharmaceuticals has successfully registered Pregabalin and Nortriptyline Tablets in Kenya.
Distribution is planned across Central America (Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama) and Central Africa (Cameroon, Chad, DRC, Equatorial Guinea, Gabon, Republic of the Congo), with further expansion into the Philippines, Saudi Arabia, the Netherlands, and Indonesia. As a leading third‑party contract pharmaceutical manufacturer, Conical Pharmaceuticals guarantees reliable supply and smooth market entry for partners worldwide.
Importers and distributors benefit from complete regulatory dossier support, including GMP Certification, Certificate of Analysis (COA), Free Sale Certificate, and COPP tailored to country‑specific requirements. With advanced R&D expertise, Conical Pharmaceuticals delivers effective formulations and consistent quality across international markets.
As a trusted bulk supplier and CDMO partner, the company supports private label and third‑party collaborations, empowering partners to expand their market presence with high‑quality hospital and supportive care therapies worldwide. Bulk supply is available to international importers, large‑scale distributors, pharmacy chains, hospital supply networks, and formulation innovators, ensuring broad accessibility and trusted partnerships across the healthcare ecosystem.
CUSTOM PACKAGING
Options available in size and style to meet your exact specifications and branding needs
SAMPLES AVAILABLE
Test before committing to bulk orders with complimentary samples for quality verification
LEAD TIME
45–60 days for timely delivery, ensuring reliable supply chain management
SHELF LIFE
Shelf Life: 24 months.
Frequently Asked Questions
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Conical Pharmaceuticals, headquartered in Ahmedabad, India, is a GMP‑certified manufacturer & exporter of Pregabalin and Nortriptyline Tablets.
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