Metoprolol Tartrate Tablets 100 mg

Precautions while taking Metoprolol Tartrate Tablets 100 mg.

Abrupt cessation of therapy with a beta-blocker should be avoided, especially in patients with ischemic heart disease. When possible, metoprolol should be withdrawn gradually over a period of 10 days, the doses diminishing to 25 mg for the last 6 days.
Although metoprolol has proved safe in a large number of asthmatic patients, it is advisable to exercise care in the treatment of patients with chronic obstructive pulmonary disease.

Metoprolol Tartrate tablets may not be administered to patients with untreated congestive heart failure. The congestive heart failure needs to be brought under control first of all.

When a beta blocker is being taken, a serious, sometimes even life-threatening deterioration in cardiac function can occur, in particular in patients in whom the action of the heart is dependent on the presence of sympathetic system support.

Before a patient undergoes an operation, the anesthetist must be informed that metoprolol is being taken.
Beta-blockers mask some of the clinical signs of thyrotoxicosis. Therefore, metoprolol should be administered with caution to patients having, or suspected of developing, thyrotoxicosis, and both thyroid and cardiac function should be monitored closely.

Metoprolol may induce or aggravate bradycardia, symptoms of peripheral arterial circulatory disorders, and anaphylactic shock.
Metoprolol may be administered when heart failure has been controlled. Digitalization and/or diuretic therapy should also be considered for patients with a history of heart failure or patients known to have a poor cardiac reserve.

Metoprolol may reduce the effect of diabetes treatment and mask the symptoms of hypoglycemia.
In patients with significant hepatic dysfunction, it may be necessary to adjust the dosage because metoprolol undergoes biotransformation in the liver. Patients with hepatic or renal insufficiency may need a lower dosage, and metoprolol is contraindicated in patients with hepatic or renal disease/failure.

Patients with anamnestically known psoriasis should take beta-blockers only after careful consideration, as the medicine may cause aggravation of psoriasis.
Beta blockers may increase both the sensitivity towards allergens and the seriousness of anaphylactic reactions.
Beta blockers may unmask myasthenia gravis.

In the presence of liver cirrhosis, the bioavailability of metoprolol may be increased, and dosage should be adjusted accordingly.