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Healthcare providers indicate Methyl Prednisolone Injection for conditions requiring a rapid and intense corticosteroid effect, such as:
Under normal circumstances Methyl Prednisolone Injection therapy would be considered as short‑term. However, the possibility of side‑effects attributable to corticosteroid therapy should be recognised, particularly when high‑dose therapy is being used (see section 4.4). Such side-effects include: Very common ≥1/10, (≥10%), Common ≥1/100 and <1/10, (≥1% and <10%), Uncommon ≥1/1000 and <1/100, (≥0.1% and <1%), Rare ≥1/10,000 and <1/1000, (≥0.01% and <0.1%), Very rare <1/10,000, (<0.01%), Not known (cannot be estimated from available data)
Infections and infestations
Opportunistic infections, Infections
Blood and lymphatic system disorders
Leucocytosis
Immune system disorders
Drug hypersensitivity, Anaphylactic reaction
Endocrine disorders
Cushingoid, Hypopituitarism, Steroid withdrawal syndrome
Metabolism and nutrition disorders
Metabolic acidosis, Sodium retention, Epidural lipomatosis, Fluid retention
Psychiatric disorders
Psychotic disorder (including mania, hallucinations, schizophrenia)
Eye disorders
Chorioretinopathy, Cataract, Glaucoma, Blurred vision
Cardiac disorders
Cardiac failure congestive, Arrhythmia
Respiratory, thoracic and mediastinal disorders
Pulmonary embolism, Hiccups
Gastrointestinal disorders
Peptic ulcer, abdominal distension, Oesophagitis, Pancreatitis
Musculo-skeletal and connective tissue disorders
Muscular weakness, Myalgia, Myopathy, Osteoporosis
Reproductive system and breast disorders
Menstruation irregular, Amenorrhoea
Immunosuppressant effects/Increased susceptibility to infections
Corticosteroids may increase susceptibility to infection, may mask some signs of infection, and new infections may appear during their use. Chickenpox is of serious concern since this normally minor illness may be fatal in immunosuppressed patients. Measles can have a more serious or even fatal course in immunosuppressed patients. Administration of live or live, attenuated vaccines is contra-indicated in patients receiving immunosuppressive doses of corticosteroids. Killed or inactivated vaccines may be administered to patients receiving immunosuppressive doses of corticosteroids; however, the response to such vaccines may be diminished.
Immune system effects
Allergic reactions may occur. Because rare instances of skin reactions and anaphylactic/anaphylactoid reactions have occurred in patients receiving parenteral corticosteroid therapy, appropriate precautionary measures should be taken prior to administration, especially when the patient has a history of allergy to any medicinal product.
Nervous system effects
Corticosteroids should be used with caution in patients with seizure disorders and myasthenia gravis. Severe medical events have been reported in association with the intrathecal/epidural routes of administration.
Ocular effects
Visual disturbance may be reported with systemic and topical corticosteroid use. Corticosteroids should be used cautiously in patients with ocular herpes simplex because of possible corneal perforation. Prolonged use of corticosteroids may produce posterior subcapsular and nuclear cataracts (particularly in children) and, exophthalmos, or increased intraocular pressure, which may result in glaucoma with possible damage to the optic nerves. Frequent ophthalmic monitoring is necessary.
Cardiac effects
High doses and prolonged courses of glucocorticoids may cause adverse effects on the cardiovascular system, such as dyslipidemia and hypertension, which can predispose patients with existing cardiovascular risk factors to additional cardiovascular issues. Use systemic corticosteroids with caution and only when strictly necessary in cases of congestive heart failure. Also, use steroids cautiously in patients with hypertension.
Gastrointestinal effects
High doses of corticosteroids may produce acute pancreatitis.When considering the use of systemic corticosteroids, healthcare providers must take particular care with patients who have the following conditions and should monitor them frequently: active or latent peptic ulceration, fresh intestinal anastomoses, abscesses or other pyogenic infections, ulcerative colitis, and diverticulitis.
Renal and urinary disorders
Providers should exercise caution with patients who have systemic sclerosis because corticosteroids, including methylprednisolone, increase the incidence of scleroderma renal crisis. Additionally, use corticosteroids cautiously in patients with renal insufficiency.
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