Gastro-Resistant Aspirin Tablets BP 75 mg use For the secondary prevention of thrombotic cerebrovascular or cardiovascular disease and following by-pass surgery.
For the management of cardiovascular or cerebrovascular disease:
Patients should seek the advice of a doctor before commencing therapy for the first time.
The usual dosage, for long-term use, is 75-150mg once daily. In some circumstances a higher dose may be appropriate, especially in the short term, and up to 300mg a day may be used on the advice of a doctor. In general, acetylsalicylic acids should be used with caution in elderly patients who are more prone to adverse events. The usual adult dose is recommended in the absence of severe renal or hepatic insufficiency. Treatment should be reviewed at regular intervals.
150 mg at diagnosis and 75mg daily thereafter. Tablets taken at diagnosis should be chewed in order to gain rapid absorption.
Do not give to children aged under 16 years, unless specifically indicated (e.g. for Kawasaki's disease).
Directions for Use
For oral administration to adults only. Tablet should be swallowed whole and not chewed.
Increased bleeding tendencies, Rare: Thrombocytopenia, granulocytosis, aplastic anaemia, Dyspepsia, Rare: Severe gastrointestinal haemorrhage, nausea, vomiting, gastritis.
Aspirin 75 mg tablets is not suitable for use as an anti-inflammatory/ analgesic/ antipyretic.
- Caution should be exercised in patients with allergic disease, impairment of hepatic or renal function (avoid if severe) and dehydration, since the use of NSAIDs may result in deterioration of renal function. Liver function tests should be performed regularly in patients presenting slight or moderate hepatic insufficiency.
Aspirin may also precipitate bronchospasm or induce attacks of asthma in susceptible subjects or promote other hypersensitivity reactions.
Serious skin reactions, including Steven-Johnsons syndrome, have rarely been reported in association with the use of acetylsalicylic acid. Aspirin Tablets should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity.
The elderly may be more susceptible to the toxic effects of salicylates. Continuous prolonged use of aspirin should be avoided in the elderly because of the risk of gastrointestinal bleeding and perforation which may be fatal. Where prolonged therapy is required, patients should be reviewed regularly.
Caution should be taken in patients with glucose-6-phosphate dehydrogenase deficiency as haemolytic anaemia may occur.
Aspirin 75 mg tablet is not recommended during menorrhagia where it may increase menstrual bleeding.
Aspirin prolongs bleeding time, mainly by inhibiting platelet aggregation and therefore it should be discontinued several days before scheduled surgical procedures.
Care is advised when stopping antiplatelet therapy after stent insertion either after a fixed period of time or in preparation for a planned surgical procedure, as the balance between stent thrombosis and excessive bleeding has to be carefully assessed.
There is a possible association between aspirin and Reye's Syndrome when given to children. Reye's syndrome is a very rare disease, which affects the brain and liver, and can be fatal. For this reason aspirin should not be given to children aged under 16 years unless specifically indicated (e.g. for Kawasaki's disease).
Aspirin should be avoided in late pregnancy and generally during breast feeding.
Store below 30°C and protect from moisture.
Keep the medicine out of reach of children.
10 x 10 Alu/Alu blister pack
Legosprin-75 is available in an Alu/Alu blister of 10 tablets. Such 10 blisters in a unit carton with package insert.