Hydrocortisone Injection USP 500 mg

Therapeutic Class: Pain Management

Dosage Forms: Injectables

Brand Name: Solnac

Solnac Injection

How it works?

Uses of Hydrocortisone Injection USP 500 mg

Hydrocortisone is indicated for any condition in which rapid and intense corticosteroid effect is required such as:

Endocrine disorders
Primary or secondary adrenocortical insufficiency

Collagen diseases
Systemic lupus erythematosus

Dermatological diseases
Severe erythema multiforme (Stevens-Johnson syndrome)

Allergic states
Bronchial asthma, anaphylactic reactions

Gastro-intestinal diseases
Ulcerative colitis, Crohn’s disease

Respiratory diseases
Aspiration of gastric contents

Medical emergencies
Doctors prescribe Hydrocortisone Injection to treat shock caused by adrenocortical insufficiency or shock that doesn’t respond to conventional therapy when adrenocortical insufficiency might be present.

Dosages administration of Hydrocortisone Injection USP 500 mg

  • You can administer Hydrocortisone Injection by intravenous injection, intravenous infusion, or intramuscular injection, with intravenous injection being the preferred method for initial emergency use. After the initial emergency period, consider using a longer-acting injectable preparation or an oral preparation.
  • Dosage usually ranges from 100 mg to 500 mg depending on the severity of the condition, administered by intravenous injection over a period of one to ten minutes. You may repeat this dose at intervals of 2, 4, or 6 hours based on the patient’s response and clinical condition.
  • Individualize dosage requirements based on the disease being treated, its severity, and the patient’s response throughout the entire duration of treatment. Make a risk/benefit decision for each individual case on an ongoing basis.
  • Determine the proper maintenance dosage by gradually decreasing the initial drug dosage in small increments at appropriate time intervals until you reach the lowest dosage that maintains an adequate clinical response.
  • Continue high-dose corticosteroid therapy only until the patient’s condition stabilizes, usually not beyond 48 to 72 hours. If you must continue hydrocortisone therapy beyond this period, hypernatremia may occur, it may be preferable to replace Hydrocortisone Injection with a corticosteroid like methylprednisolone sodium succinate, as it causes little or no sodium retention.
  • Minimize undesirable effects by using the lowest effective dose for the shortest period necessary.
  • You can minimize undesirable effects by using the lowest effective dose for the shortest period necessary.
  • Corticosteroid therapy is an adjunct to, and not a replacement for, conventional therapy.
  • In patients with liver disease, the treatment may have an increased effect, thats why consider reducing the dosage.

 

Pediatric population:

  • Reduce the dosage for infants and children based on the severity of the condition and the patient’s response, not on age or size.
  • Dosage should not be less than 25 mg daily.

 

Elderly patients:

  • Healthcare providers primarily use Hydrocortisone Injection for acute short-term conditions. When administered as directed, there is no evidence suggesting a need for dosage changes in elderly patients. However, when planning long-term treatment, providers should consider the serious consequences of corticosteroid side effects in this age group and ensure close supervision.

Side effects of Hydrocortisone Injection USP 500 mg

The incidence of predictable undesirable side effects associated with the use of corticosteroids, including hypothalamic-pituitary-adrenal suppression correlates with the relative potency of the drug, dosage, timing of administration and duration of treatment. Such side-effects include:Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1,000 to <1/100), Rare (≥1/10,000 to <1/1,000), Very rare (<1/10,000), Not known (cannot be estimated from the available data).

Frequency: Not Known

Infections and infestations
Opportunistic infections, infections

Blood and lymphatic system disorders
Leucocytosis

Immune system disorders
Drug hypersensitivity Anaphylactic reaction, Anaphylactoid reaction

Endocrine disorders
Cushingoid facies, Hypopituitarism, Steroid withdrawal syndrome

Metabolism and nutrition disorders
Metabolic acidosis, Sodium retention, Fluid retention, Alkalosis hypokalaemic, Dyslipidaemia

Psychiatric disorders
Affective disorders, Psychotic disorder, Mental disorder

Eye disorders
Central serous chorioretinopathy, Cataracts, Glaucoma, Exophthalmos, Vision blurred

Cardiac disorders
Congestive heart failure

Respiratory, thoracic and mediastinal disorders
Pulmonary embolism, Hiccups

Gastrointestinal disorders
Peptic ulcer, abdominal distension, oesophageal ulceration, acute pancreatitis

Reproductive system and breast disorders
Irregular menstruation, Amenorrhoea

Precautions of Hydrocortisone Injection USP 500 mg

When considering the use of systemic corticosteroids, healthcare providers must take particular care with patients who have the following conditions and monitor them frequently.

  1. Long-term use and large doses of glucocorticoids generally cause osteoporosis. Use corticosteroids with caution in patients with osteoporosis, especially post-menopausal females who are particularly at risk.
  2. Hypertension.
  3. Existing or previous history of severe affective disorders (especially previous steroid psychosis).
  4. Corticosteroids, including hydrocortisone, can increase blood glucose, worsen pre‑existing diabetes, and predispose those on long‑term corticosteroid therapy to diabetes mellitus (or a family history of diabetes).
  5. History of tuberculosis.
  6. Glaucoma (or a family history of glaucoma).
  7. Previous corticosteroid-induced myopathy.
  8. Liver failure or cirrhosis.
  9. Use corticosteroids with caution in patients who have renal insufficiency.
  10. Epilepsy.
  11. Peptic ulceration.
  12. Fresh intestinal anastomoses.
  13. Predisposition to thrombophlembitis.
  14. Abscess or other pyogenic infections.
  15. Ulcerative colitis.
  16. Diverticulitis.
  17. Myasthenia gravis.
  18. Exanthematous diseases.

Storage instruction of Hydrocortisone Injection USP 500 mg

  • Store below 30°C. Protected from light.
  • Use the reconstituted solution immediately. If you do not use it right away, you can store it for 24 hours at 2°C to 8°C under aseptic conditions. If not used immediately, in-use storage times and conditions are the responsibility of the user.
  • Keep the medicine out of reach of children.

Packing details of Hydrocortisone Injection USP 500 mg

  • 10 ml Clear molded Glass Vial with a grey bromobutyl rubber stopper, sealed with an orange flip-off aluminum seal.
  • Hydrocortisone Sodium Succinate for Injection USP 500 mg powder for solution in a glass vial within a unit carton that includes a pack insert.

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