Hydrocortisone Injection
Therapeutic Class: Pain Management
Dosage Forms: Injectables
Brand Name: Solnac™
How it works?
Uses of Hydrocortisone Injection
- Endocrine disorders → Essential in managing primary and secondary adrenocortical insufficiency.
- Collagen diseases → Effective in systemic lupus erythematosus and related autoimmune conditions.
- Severe dermatological conditions → Used in erythema multiforme (Stevens‑Johnson syndrome) and other serious skin disorders.
- Allergic states → Provides rapid relief in bronchial asthma and anaphylactic reactions.
- Gastrointestinal diseases → Valuable in ulcerative colitis and Crohn’s disease management.
- Respiratory emergencies → Used in aspiration of gastric contents and acute airway inflammation.
- Shock management → Critical in treating shock secondary to adrenocortical insufficiency or when conventional therapy fails.
Precautions of Hydrocortisone Injection
Doctors must exercise particular care when considering the use of systemic corticosteroids in patients with the following conditions, and they need to monitor patients frequently:
1. Osteoporosis: Doctors should exercise caution when using corticosteroids in patients with osteoporosis, especially since long-term use and large doses of glucocorticoids generally associate with osteoporosis, putting post-menopausal females at particular risk.
2. Hypertension: This condition warrants caution when using corticosteroids.
3. Severe Affective Disorders: A history of severe affective disorders, especially previous steroid psychosis, necessitates careful consideration.
4. Diabetes: Corticosteroids, including hydrocortisone, can increase blood glucose levels, worsen pre-existing diabetes, and predispose those on long-term corticosteroid therapy to diabetes mellitus, particularly with a family history of diabetes.
5. Tuberculosis: A history of tuberculosis, whether existing or in the patient’s past, requires special care.
6. Glaucoma: Therefore, Doctors should closely monitor patients with glaucoma or a family history of glaucoma.
7. Corticosteroid-Induced Myopathy: Consequently, a previous history of this condition requires caution in corticosteroid use.
8. Liver Failure or Cirrhosis: Therefore, patients with these conditions need careful assessment.
9. Renal Insufficiency: Doctors should exercise caution when prescribing corticosteroids to these patients.
10. Epilepsy: Requires special attention when using corticosteroids.
11. Peptic Ulceration: Therefore, Doctors should consider this condition carefully.
12. Fresh Intestinal Anastomoses: As a result, Doctors should exercise caution with these patients.
13. Thrombophlebitis: Thus, a predisposition to this condition necessitates monitoring.
14. Pyogenic Infections: Consequently, patients with abscesses or other pyogenic infections require careful monitoring.
15. Ulcerative Colitis: For this reason, this condition needs special consideration.
16. Diverticulitis: Accordingly, close monitoring is necessary.
17. Myasthenia Gravis: Hence, Doctors should carefully assess patients with this condition.
18. Exanthematous Diseases: Doctors should exercise caution when considering corticosteroids for these patients.
Dosages administration of Hydrocortisone Injection
- Routes of administration → May be given by intravenous injection, intravenous infusion, or intramuscular injection.
- Preferred emergency use → Intravenous injection is the recommended route for initial emergency treatment.
- Individualized assessment → Doctors assess the patient’s condition to determine the most suitable route for subsequent doses.
- Transition to maintenance therapy → After the emergency period, longer‑acting injectable or oral preparations are considered for ongoing management.
- Dosage range → Typically 100 mg to 500 mg depending on severity, administered by IV injection over 1–10 minutes.
- Monitoring during administration → Patients should be closely monitored to assess effectiveness and adjust dosage if necessary.
- Repeat dosing → Doses may be repeated at intervals of 2, 4, or 6 hours based on clinical response.
Side effects of Hydrocortisone Injection
The incidence of predictable undesirable side effects associated with corticosteroid use, including hypothalamic-pituitary-adrenal suppression, correlates with several factors: specifically, the relative potency of the drug, the dosage, the timing of administration, and the duration of treatment. Moreover, such side effects include: Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1,000 to <1/100), Rare (≥1/10,000 to <1/1,000), Very rare (<1/10,000), Not known (cannot be estimated from the available data).
Frequency: Not Known
Infections and Infestations
Patients may experience opportunistic infections and other infections.
Blood and Lymphatic System Disorders
Patients may develop leucocytosis.
Immune System Disorders
Patients may have drug hypersensitivity, which can lead to an anaphylactic reaction or an anaphylactoid reaction.
Endocrine Disorders
Patients may present with Cushingoid facies, hypopituitarism, or steroid withdrawal syndrome.
Metabolism and Nutrition Disorders
Patients may experience metabolic acidosis, sodium retention, fluid retention, hypokalaemic alkalosis, and dyslipidaemia.
Psychiatric Disorders
Patients may suffer from affective disorders, psychotic disorders, or mental disorders.
Eye Disorders
Patients may develop central serous chorioretinopathy, cataracts, glaucoma, exophthalmos, or blurred vision.
Cardiac Disorders
Patients may experience congestive heart failure.
Respiratory, Thoracic and Mediastinal Disorders
Patients may develop pulmonary embolism or experience hiccups.
Gastrointestinal Disorders
Patients may suffer from peptic ulcers, abdominal distension, oesophageal ulceration, or acute pancreatitis.
Reproductive System and Breast Disorders
Patients may experience irregular menstruation or amenorrhoea.
Storage instruction of Hydrocortisone Injection
Store below 30o C. Protected from light.
The reconstituted solution to be used immediately. If not used, can be stored for 24 hours at 2°C to 8°C at aseptic condition. If not used immediately, in-use storage times and conditions are the responsibility of the user.
Keep the medicine out of reach of children.
Packing details of Hydrocortisone Injection
10 ml Clear-molded Glass Vial with a grey bromobutyl rubber stopper, sealed with an orange flip-off aluminum seal. Hydrocortisone Sodium Succinate for Injection USP 500 mg powder for solution for injection is supplied in a glass vial in a unit carton with a pack insert.
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Reliable GMP Certified Hydrocortisone Injection Manufacturer
Conical Pharmaceuticals, headquartered in Ahmedabad, India, is GMP‑certified manufacturer & exporter of Hydrocortisone Injection. We are delivering premium pharmaceutical and nutraceutical solutions worldwide. With exports planned into Central Africa, Central America, and the CIS Region, and a strong distribution network across Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama, Cameroon, Chad, DRC, Equatorial Guinea, Gabon, and the Republic of the Congo, we ensure reliable supply and smooth market entry. Expansion into Nigeria, Ghana, Zambia, Zimbabwe, Kenya, the Philippines, Singapore, and Afghanistan further strengthens our global footprint. Conical Pharmaceutical has successfully registered Hydrocortisone Injection in Myanmar.
Importers benefit from complete regulatory dossier support, including GMP Certification, COPP, COA, and Free Sale Certificates as per requirements. We also provide third‑party contract manufacturing, private labelling, and custom formulation options, empowering partners to launch their own brands with tailored solutions.
As a trusted contract manufacturer of Hydrocortisone Injection, Conical Pharmaceuticals supplies to international importers, large distributors, pharmacy chains, and hospitals. With advanced R&D, flexible MOQ options, and consistent quality assurance, we enable partners to expand their market presence while delivering effective, high‑quality pharmaceutical solutions worldwide. Custom formulations are available to meet diverse consumer preferences.
CUSTOM PACKAGING
Options available in size and style to meet your exact specifications and branding needs
SAMPLES AVAILABLE
Test before committing to bulk orders with complimentary samples for quality verification
LEAD TIME
45–60 days for timely delivery, ensuring reliable supply chain management
SHELF LIFE
Shelf Life: 24 months.
Frequently Asked Questions
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Conical Pharmaceuticals, headquartered in Ahmedabad, India, is a GMP‑certified manufacturer & exporter of Herbal Pain Relief Gel.
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