Labetalol Tablets BP 100 mg is a combined alpha and beta-adrenoceptor blocker indicated for:
Hypertension, including hypertension in pregnancy.
Angina pectoris with existing hypertension.
Labetalol Tablets BP 100 mg For oral administration only. Labetalol tablets should be taken with food.
Positive antinuclear antibodies unassociated with disease, Dizziness, tingling sensation in scalp usually transient may occur in a few patients early in treatment, Very rare: Tremor has been reported in the treatment of hypertension of pregnancy, Heart failure, Rare: Bradycardia, Very rare: Heart block, Raised liver function tests, Very rare: Jaundice (both hepatocellular and cholestatic), hepatitis and hepatic necrosis. When mild, hepatotoxicity is usually reversible on withdrawal of the drug, Ejaculatory failure, erectile dysfunction, Drug fever.
There have been reports of skin rashes and/or dry eyes associated with the use of beta-adrenoceptor blocking drugs.
There have been reports of severe hepatocellular injury with Labetalol therapy.
Particular care should be taken when labetalol is used in patients with hepatic impairment.
Particular care is required with patients whose cardiac reserve is poor.
Airway obstructions may be aggravated in patients with chronic obstructive pulmonary disorders. Non-selective beta-blockers, such as Labetalol, should not be used for these patients unless no alternative treatment is available.
Labetalol should only be given with caution to patients with first-degree heart block due to its negative effect on conduction time.
Beta adrenoceptor blocking drugs may increase the number and duration of anginal attacks in patients with Prinzmetal's angina, due to unopposed alpha-receptor mediated coronary artery vasoconstriction. Non-selective beta-blockers, such as Labetalol, should not be used for these patients.
Patients with a history of psoriasis should only be administered beta adrenoceptor blockers after careful consideration.
There have been reports of increased sensitivity towards allergens and the seriousness of anaphylactic reactions with the use of beta adrenoceptor blocking drugs.
Labetalol modifies the tachycardia of hypoglycaemia and it may prolong the hypoglycaemic response to insulin.
Because of negative inotropic effects, care is required when prescribing a beta-adrenoceptor blocking drug with class 1 antidysrhythmic agents such as disopyramide.
Care is required during parenteral administration of preparations containing adrenaline to patients receiving beta-adrenoceptor blocking drugs, as in rare instances vasoconstriction, hypertension and bradycardia may occur.
Great care should be taken with patients with peripheral circulatory disorders such as Raynaud's disease or syndrome or intermittent claudication.
In patients with phaeochromocytoma, labetalol may be administered only after adequate alpha-blockade is achieved.
All labelling for Labetalol will carry the following warning:
Do not take this medicine if you have wheezing or asthma.
Store below 30oC. Protect from light and moisture.
Keep out of reach of children.
3 x 10 Alu/Alu blister pack
Hybetol-100 is available in an Alu/Alu blister of 10 tablets. Such 03 blisters in a unit carton with package insert.