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Labetalol Tablets BP 100 mg is a combined alpha and beta-adrenoceptor blocker indicated for:
Hypertension, including hypertension in pregnancy.
Angina pectoris with existing hypertension.
Labetalol Tablets BP 100 mg For oral administration only. Take Labetalol tablets with food.
Positive antinuclear antibodies may occur without association to disease. Some patients may experience transient dizziness and tingling sensations in the scalp early in treatment. Very rarely, patients treated for hypertension during pregnancy report tremors.Heart failure may develop, and bradycardia is rare. Very rarely, heart block can occur, along with raised liver function tests. Jaundice, both hepatocellular and cholestatic, as well as hepatitis and hepatic necrosis, may occur very rarely. When mild, hepatotoxicity is usually reversible on withdrawal of the drug, Ejaculatory failure, erectile dysfunction, Drug fever.
There have been reports of skin rashes and/or dry eyes associated with the use of beta-adrenoceptor blocking drugs.
There have been reports of severe hepatocellular injury with Labetalol therapy.
Take particular care when using labetalol in patients with hepatic impairment.
Take particular care with patients who have poor cardiac reserve.
Airway obstructions may worsen in patients with chronic obstructive pulmonary disorders. Avoid using non-selective beta-blockers, like Labetalol, for these patients unless no alternative treatment is available.
Administer labetalol with caution to patients with first-degree heart block because it negatively affects conduction time.
Beta adrenoceptor blocking drugs may increase the number and duration of anginal attacks in patients with Prinzmetal’s angina, due to unopposed alpha-receptor mediated coronary artery vasoconstriction. Do not use non-selective beta-blockers, such as Labetalol, for these patients.
Administer beta adrenoceptor blockers to patients with a history of psoriasis only after careful consideration.
There have been reports of increased sensitivity towards allergens and the seriousness of anaphylactic reactions with the use of beta adrenoceptor blocking drugs.
Labetalol modifies the tachycardia of hypoglycaemia and it may prolong the hypoglycaemic response to insulin.
Exercise caution when prescribing a beta-adrenoceptor blocking drug with class 1 antidysrhythmic agents like disopyramide due to negative inotropic effects.
Exercise caution during the parenteral administration of preparations containing adrenaline to patients receiving beta-adrenoceptor blocking drugs, as rare instances of vasoconstriction, hypertension, and bradycardia may occur.
Take great care with patients who have peripheral circulatory disorders, such as Raynaud’s disease or syndrome, or intermittent claudication.
Administer labetalol to patients with phaeochromocytoma only after achieving adequate alpha-blockade.
All labelling for Labetalol will carry the following warning:
Do not take this medicine if you have wheezing or asthma.
Store below 30oC. Protect from light and moisture.
Keep out of reach of children.
3 x 10 Alu/Alu blister pack
Hybetol-100 is available in an Alu/Alu blister of 10 tablets. Such 03 blisters in a unit carton with package insert.
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