Esomeprazole Sodium For Tablet
- Esomeprazole Tablets 40 mg
Therapeutic Class: Gastrointestinals
Dosage Forms: Tablets
Brand Name: Coniloc-E™
How it works?
Uses of Esomeprazole Sodium For Tablet
Esomeprazole Sodium For Tablets are mainly used for:
Adults
Gastroesophageal Reflux Disease (GERD)
– Treatment of erosive reflux esophagitis.
– Long-term management of patients with healed esophagitis to prevent relapse.
– Symptomatic treatment of gastroesophageal reflux disease (GERD)
– In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori and Healing of Helicobacter pylori-associated duodenal ulcer and Prevention of relapse of peptic ulcers in patients with Helicobacter pylori-associated ulcers
Patients requiring continued NSAID therapy. – Healing of gastric ulcers associated with NSAID therapy.
– Prevention of gastric and duodenal ulcers associated with NSAID therapy in patients at risk.
– Prolonged treatment after i.v.-induced prevention of rebleeding of peptic ulcers.
-Treatment of Zollinger-Ellison Syndrome
-Adolescents from the age of 12 years
-Gastroesophageal Reflux Disease (GERD)
– treatment of erosive reflux esophagitis
– long-term management of patients with healed esophagitis to prevent relapse
– symptomatic treatment of gastroesophageal reflux disease (GERD)
In combination with antibiotics in treatment of duodenal ulcer caused by Helicobacter pylori
Precautions of Esomeprazole Sodium For Tablet
Precautions While Taking Esomeprazole Sodium Tablets
- Drug interactions in triple therapy → When used for Helicobacter pylori eradication, consider interactions of all components. Clarithromycin strongly inhibits CYP3A4, so caution is required with drugs metabolized via CYP3A4 (e.g., cisapride).
- Risk of gastrointestinal infections → Proton pump inhibitors (PPIs) may slightly increase the risk of infections such as Salmonella and Campylobacter.
- Interaction with atazanavir → Co‑administration is not recommended. If unavoidable, close monitoring is required, with atazanavir increased to 400 mg + ritonavir 100 mg, and esomeprazole not exceeding 20 mg daily.
- Fracture risk with long‑term use → High doses or prolonged use (>1 year) may modestly increase risk of hip, wrist, and spine fractures, especially in elderly patients or those with risk factors.
- Osteoporosis management → Patients at risk should follow clinical guidelines and ensure adequate intake of vitamin D and calcium.
Dosages administration of Esomeprazole Sodium For Tablet
Dosages of Esomeprazole Sodium For tablet
Adults and adolescents from the age of 12 years
Gastroesophageal Reflux Disease (GERD)
– Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks.
– An additional 4 weeks of treatment is recommended for patients in whom esophagitis has not healed or who have persistent symptoms.
– Long-term management of patients with healed esophagitis to prevent relapse: 20 mg once daily.
– Symptomatic treatment of gastroesophageal reflux disease (GERD): 20 mg once daily in patients without esophagitis.
– If symptom control has not been achieved after 4 weeks, the patient should be further investigated. Once symptoms have resolved, subsequent symptom control can be achieved using 20 mg once daily.
– In adults, an on-demand regimen taking 20 mg once daily, when needed, can be used. In NSAID-treated patients at risk of developing gastric and duodenal ulcers, subsequent.
Symptom control using an on-demand regimen is not recommended.
Adults
In combination with appropriate antibacterial therapeutic regimens for the
eradication of Helicobacter pylori and
– Healing of Helicobacter pylori-associated duodenal ulcer and
– Prevention of relapse of peptic ulcers in patients with Helicobacter pylori-associated ulcers.
-Esomeprazole 20 mg with 1 g amoxicillin and 500 mg clarithromycin, all twice daily for 7 days.
Patients requiring continued NSAID therapy
Healing of gastric ulcers associated with NSAID therapy: The usual dose is 20 mg once daily. The treatment duration is 4-8 weeks.
Prevention of gastric and duodenal ulcers associated with NSAID therapy in patients at risk: 20 mg once daily.
Prolonged treatment after i.v.-induced prevention of rebleeding of peptic ulcers.
40 mg once daily for 4 weeks after i.v.-induced prevention of rebleeding of peptic ulcers.
Treatment of Zollinger-Ellison Syndrome
The recommended initial dose is 40 mg twice daily. The dose should then be individually adjusted and treatment continued as long as clinically indicated. Based on the clinical data available, the majority of patients can be controlled on doses between 80 to 160 mg of esomeprazole daily. With doses above 80 mg daily, the dose should be divided and given twice daily.
Adolescents from the age of 12 years
Treatment of duodenal ulcer caused by Helicobacter pylori
When selecting appropriate combination therapy, consideration should be given to official national, regional and local guidance regarding bacterial resistance, duration of treatment (most commonly 7 days but sometimes up to 14 days), and appropriate use of antibacterial agents. The treatment should be supervised by a specialist.
Children below the age of 12 years
Esomeprazole should not be used in children younger than 12 years since no data is available.
Impaired renal function
Dose adjustment is not required in patients with impaired renal function. Due to limited experience in patients with severe renal insufficiency, such patients should be treated with caution.
Impaired hepatic function
Dose adjustment is not required in patients with mild to moderate liver impairment. For patients with severe liver impairment, a maximum dose of 20 mg esomeprazole should not be exceeded.
Elderly
Dose adjustment is not required in the elderly.
Directions for use
The tablets should be swallowed whole with a glass of water. The tablets should not be chewed or crushed.
Side effects of Esomeprazole Sodium For Tablet
Hematologic Side Effects
- Leukopenia → Reduced white blood cell count, increasing susceptibility to infections.
- Thrombocytopenia → Low platelet count, increasing risk of bleeding or bruising.
Hypersensitivity Reactions
- Fever → May occur as part of allergic response.
- Angioedema → Swelling of face, lips, or throat.
- Anaphylactic reaction/shock → Rare but potentially life‑threatening allergic reaction.
Gastrointestinal Side Effects
- Abdominal pain → Common digestive discomfort.
- Constipation → Reduced bowel movement frequency.
- Diarrhoea → Loose stools or digestive upset.
- Flatulence → Excess gas or bloating.
- Nausea/vomiting → Common mild gastrointestinal reactions.
General Side Effects
- Malaise → General feeling of discomfort or fatigue.
- Increased sweating → Excess perspiration reported in some patients.
Storage instruction of Esomeprazole Sodium For Tablet
Store below 30°C temperature and protect from light.
Keep the medicine out of reach of children.
Packing details of Esomeprazole Sodium For Tablet
Alu-Alu blister packs.
Esomeprazole Sodium For Tablet is available in an Alu-Alu blister of 10 tablets. Such 10 blisters in a unit carton with a package insert.
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Reliable GMP Certified Esomeprazole Sodium For Tablet Manufacturer
Conical Pharmaceuticals, headquartered in Ahmedabad, India, is a GMP‑certified manufacturer & exporter of Esomeprazole Sodium Tablets, delivering premium pharmaceutical and nutraceutical solutions worldwide.
Esomeprazole belongs to the proton pump inhibitor (PPI) class. It works by reducing gastric acid secretion, making it highly effective in the management of acid‑related disorders. Conical Pharmaceutical has successfully registered this tablet in cambodia.
With exports planned into Central Africa, Central America, and the CIS Region, and a strong distribution network across Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama, Cameroon, Chad, DRC, Equatorial Guinea, Gabon, and the Republic of the Congo, we ensure reliable supply and smooth market entry. Expansion into Nigeria, Ghana, Zambia, Zimbabwe, Kenya, the Philippines, Singapore, and Afghanistan further strengthens our global footprint.
Importers benefit from complete regulatory dossier support, including GMP Certification, COPP, COA, and Free Sale Certificates as per requirements. We also provide third‑party contract manufacturing, private labeling, and custom formulation options, empowering partners to launch their own brands with tailored solutions.
As a trusted contract manufacturer of gastroenterology solutions, Conical Pharmaceuticals supplies to international importers, large distributors, pharmacy chains, and hospitals. With advanced R&D, flexible MOQ options, and consistent quality assurance, we enable partners to expand their market presence while delivering effective, high‑quality pharmaceutical solutions worldwide.
CUSTOM PACKAGING
Options available in size and style to meet your exact specifications and branding needs
SAMPLES AVAILABLE
Test before committing to bulk orders with complimentary samples for quality verification
LEAD TIME
45–60 days for timely delivery, ensuring reliable supply chain management
SHELF LIFE
Shelf Life: 24 months.
Frequently Asked Questions
Questions are useful tools, they open lines of communication; give us information; improve interactions, facilitate analysis, and many more.
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Yes, Conical Pharmaceuticals is a GMP‑certified manufacturer in Ahmedabad, India, producing premium gastroenterology formulations.
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