Neomycin, Polymyxin B Sulfates and Bacitracin Ointment USP

Bacnaid ointment is indicated in conditions where superficial bacterial skin infection is present or likely to occur. These include:
Prophylaxis in graft donor sites, the suturing of lacerations, accidental cuts, scratches and abrasions.
Treatment of infected ulcers, accidental cuts, scratches and abrasions and superficial skin infections following surgical procedures and minor burns, impetigo and secondarily infected skin conditions.
The use of Bacnaid ointment does not exclude concomitant systemic therapy with antibiotics where appropriate.

Bacnaid ointment is for topical skin application only. It is not for oral, ophthalmic, or intranasal use.
Adults:
Following any necessary removal of debris, such as pus, crusts, etc. from the affected area, a thin film of ointment should be applied one to three times daily, depending on the clinical condition or as prescribed by the physician.
Treatment should not be continued for more than seven days without medical supervision.
Children:
Bacnaid ointment is suitable for use in children (two years and over) at the same dose as adults. A possibility of increased absorption exists in very young children, thus the product is not recommended for use in neonates and infants (less than two years).
Elderly:
Bacnaid ointment is suitable for use in the elderly. Caution should be exercised in cases where a decrease in renal function exists and significant systemic absorption of Neomycin Sulfate may occur.
Renal Impairment:
Dosage should be reduced in patients with reduced renal function.

The incidence of allergic hypersensitivity reactions to Neomycin Sulfate in the general population is low. There is, however, an increased incidence of hypersensitivity to Neomycin in certain selected groups of patients in dermatological practice particularly those with venous stasis eczema and ulceration.
Allergic hypersensitivity to neomycin sulfate following topical application may manifest itself as a reddening and scaling of the affected skin, as an eczematous exacerbation of the lesion or as a failure of the lesion to heal.
Allergic hypersensitivity reactions following topical application of polymyxin B sulfate and bacitracin zinc are rare events but have been reported.
Anaphylactic reactions following the topical administration of bacitracin zinc have been reported; but these are rare occurrences.
Immune Systems Disorders
Rare: Application site hypersensitivity.
General Disorders and Administration Site Conditions
Rare: Application site reaction including pain, erythema, oedema, pruritus and exacerbation of underlying skin conditions.

Bacnaid ointment is for topical skin application only. It is not for oral, ophthalmic, or intranasal use.
As with all antibacterial preparations, prolonged use may result in the overgrowth of non-susceptible organisms, including fungi.
Pseudomembranous colitis has been reported with the use of antibiotics and may range in severity from mild to life-threatening. Therefore, it is important to consider its diagnosis in patients who develop diarrhoea during or after antibiotic use. Although this is unlikely to occur with topically applied antibiotics, if prolonged or significant diarrhoea occurs or the patient experiences abdominal cramps, treatment should be discontinued immediately and the patient investigated further.
Following significant systemic absorption, aminoglycosides such as neomycin can cause irreversible ototoxicity; neomycin sulfate, polymyxin B sulfate and bacitracin zinc have nephrotoxic potential and polymyxin B sulfate has neurotoxic potential.
In renal impairment the plasma clearance of neomycin is reduced.
The concurrent use of other aminoglycoside antibiotics is not recommended in circumstances where significant systemic absorption of neomycin sulfate could occur following topical application.

Store below 30° C preferably in cool and dry place. Protect from light.
Keep the medicine out of reach of children.

Lami tube with white cap containing 15 g of ointment. Such 01 tube in a monocarton with pack insert.